Effect of mesenchymal stem cells associated to matrixen on the erectile function in the rat model with bilateral cavernous nerve crushing injury

International Braz J Urol

Volumn 38, Issue 6, 2012, Pages 833-841

  Kim, Su Jin ^a   Park, Sang Hoon ^b   Sung, Young Chul ^b   Kim, Sae Woong ^a  

^a The Catholic University of Korea   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Cavernous nerve; Erectile dysfunction; Matrixen; Mesenchymal stem cell

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, MOUSE; NOS3 PROTEIN, RAT;

ANIMAL; ANIMAL MODEL; ARTICLE; DRUG EFFECT; ERECTILE DYSFUNCTION; FLUORESCENT ANTIBODY TECHNIQUE; INNERVATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PENIS; PENIS ERECTION; RAT; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; ERECTILE DYSFUNCTION; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MODELS, ANIMAL; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PENILE ERECTION; PENIS; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 84874858735     PISSN: 16775538     EISSN: 16776119     Source Type: Journal    
DOI: 10.1590/1677-553820133806833     Document Type: Article

References (23)

1. Schröder FH, Carter HB, Wolters T, van den Bergh RC, Gos-selaar C, Bangma CH, et al.: Early detection of prostate cancer in 2007. Part 1: PSA and PSA kinetics. Eur Urol. 2008; 53: 468-77.
2. Bove P, Asimakopoulos AD, Kim FJ, Vespasiani G: Lapa-roscopic radical prostatectomy: a review. Int Braz J Urol. 2009; 35: 125-37; discussion 137-9.
3. Walsh PC: Radical prostatectomy for localized prostate cancer provides durable cancer control with excellent quality of life: a structured debate. J Urol. 2000; 163: 1802-7.
4. Montorsi F, Salonia A, Suardi N, Gallina A, Zanni G, Brig-anti A, et al.: Improving the preservation of the urethral sphincter and neurovascular bundles during open radical retropubic prostatectomy. Eur Urol. 2005; 48: 938-45.
5. Graefen M, Walz J, Huland H: Open retropubic nerve-sparing radical prostatectomy. Eur Urol. 2006; 49: 38-48.
6. Zippe CD, Pahlajani G: Penile rehabilitation following radical prostatectomy: role of early intervention and chronic therapy. Urol Clin North Am. 2007; 34: 601-18.
7. Deans RJ, Moseley AB: Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000; 28: 875-84.
8. Lee JY, Cannon TW, Pruchnic R, Fraser MO, Huard J, Chancellor MB: The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dys-funct. 2003; 14: 31-7; discussion 37.
9. Xu Y, Song Y F, Lin ZX: Transplantation of muscle-derived stem cells plus biodegradable fibrin glue restores the ure-thral sphincter in a pudendal nerve-transected rat model. Braz J Med Biol Res. 2010; 43: 1076-83.
10. Lee HN, Lee JY, Koh JS, Kim HW, Byun SS, Lee SS, et al.: Muscle Derived Stem Cell/Alginate/Polycaprolactone/Injec-tion Therapy in Rats with Denervated Urethral Sphincter. Korean J Urol. 2007; 48: 1296-1301.
11. Canguven O, Burnett A: Cavernous nerve injury using rodent animal models. J Sex Med. 2008; 5: 1776-85.
12. Palma CA, Keast JR: Structural effects and potential changes in growth factor signalling in penis-projecting autonom-ic neurons after axotomy. BMC Neurosci. 2006; 7: 41.
13. Carrier S, Zvara P, Nunes L, Kour NW, Rehman J, Lue TF: Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J Urol. 1995; 153: 1722-7.
14. Harraz A, Shindel AW, Lue TF: Emerging gene and stem cell therapies for the treatment of erectile dysfunction. Nat Rev Urol. 2010; 7: 143-52.
15. Müller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, et al.: Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol. 2002; 34: 107-16.
16. Reinecke H, Murry CE: Taking the death toll after cardio-myocyte grafting: a reminder of the importance of quantitative biology. J Mol Cell Cardiol. 2002; 34: 251-3.
17. Gutowska A, Jeong B, Jasionowski M: Injectable gels for tissue engineering. Anat Rec. 2001; 263: 342-9.
18. Natesan S, Baer DG, Walters TJ, Babu M, Christy RJ: Adipose-derived stem cell delivery into collagen gels using chitosan microspheres. Tissue Eng Part A. 2010; 16: 1369-84.
19. Jeong B, Bae YH, Kim SW: In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J Biomed Mater Res. 2000; 50: 171-7.
20. Jeong B, Bae YH, Kim SW: Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Control Release. 2000; 63: 155-63.
21. Lee JY, Paik SY, Yuk SH, Lee JH, Ghil SH, Lee SS: The Isolation and Characterization of Muscle Derived Stem Cells from Gastrocnemius Muscle of Rats Using the Modified Preplate Method. Korean J Urol. 2004; 45: 1279-84.
22. Deans RJ, Moseley AB: Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000; 28: 875-84.
23. Levy YS, Bahat-Stroomza M, Barzilay R, Burshtein A, Bulvik S, Barhum Y, et al.: Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease. Cytotherapy. 2008; 10: 340-52.