Effect of methylprednisolone on the axonal impairment accompanying cellular brain oedema induced by water intoxication in rats

Neuroendocrinology Letters

Volumn 33, Issue 8, 2012, Pages 782-786

  Kozler, Petr ^a   Pokorný, Jaroslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Axonal impairment; Brain oedema; Cellular oedema; Methylprednisolone; Myelin staining; Neuroprotection; Water intoxication

Indexed keywords

METHYLPREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; CELL METABOLISM; CONTROLLED STUDY; DENTATE GYRUS; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HISTOLOGY; MALE; MYELIN SHEATH; NERVE FIBER DEGENERATION; NEUROPATHY; NEUROPROTECTION; NONHUMAN; RAT; VARICOSIS; WATER INTOXICATION;

EID: 84874813781     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Alderson P, Roberts I (1997). Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials. BMJ 314: 1855-1859. (Pubitemid 27263242)
2. Bracken MB, Shepard MJ, Holford TR, et al. (1997). Administration of methylprednisolone for 24 or 48 hours or tirilizad mesylate for 48 hours in the treatment of acute spinal cord injury. JAMA 277: 1597-1604.
3. Creed JA, DiLeonardi AM, Fox DP, Tessler AR, Raghupathi R (2011). Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function. J Neurotrauma. 28: 547-63.
4. Czekajlo MS, Milbrandt EB (2005). Corticosteroids increased short and long-term mortality in adults with traumatic head injury. Crit Care. 8;9: E21.
5. Edwards P, Arango M, Balica L et al. (2005). Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet. 365: 1957-1959.
6. Gasparova Z, Janega P, Babal P, Snirc V, Stole S, Mach M, Ujhazy E (2009). Effect of the new pyridoindole antioxidant SMe1EC2 on functional deficits and oedema formation in rat hippocampus exposed to ischaemia in vitro. Neuroendocrinol Lett. 30: 574-581.
7. Go KG (1997). The normal and pathological physiology of brain water. Adv Tech Stand Neurosurg. 23: 47-142.
8. Hall ED (1992). The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76: 13-22.
9. 2+ATPase activity and lipid peroxidation and ultrastructural findings following cerebral contusion in rat. Surg. Neurol. 44: 573-580.
10. Kimelberg HK(1995). Current concepts of brain edema. J Neurosurg. 83: 1051-1095,
11. Kozler P, Riljak V, Pokorny J (2011) Methylprednisolone reduces axonal impairment in the experimental model of brain oedema. Neuroendocrinol Lett. 32: 101-105.
12. Lin SZ, Chiou TL, Chiang YH, Song WS (1994). Combined treatment with nicardipine, phenobarbital, and methylprednisolone ameliorates vasogenic brain edema. Acta Neurochir. 60: 528-530.
13. Manley GT, Fujimura M, Ma T (2000): Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 6: 159-163. (Pubitemid 30082359)
14. Marmarou A, Signoretti S, Aygok G, Fatouros P, Portella G (2006): Traumatic brain edema in diffuse and focal injury: cellular or vasogenic? Acta Neurochir Suppl. 96: 24-9.
15. Marshall LF (2000). Head injury: recent past, present, and future. Neurosurgery 47: 546-561.
16. Olson JE, Evers JA, Banks M (1994). Brain osmolyte content and blood-brain barrier water permeability surface area product in osmotic edema. Acta Neurochir Suppl. 60: 571-573.
17. Onaya M (2002). Neuropathological investigation of cerebral white matter lesions caused by closed head injury. Neuropathology. 22: 243-51.
18. Park C.O. (1998). The effects of methylprednisolone on prevention of brain edema after experimental moderate diffuse brain injury in rats: comparison between dosage, injection time, and treatment methods. Yonsei Med. J. 39: 395-403.
19. Rapoport SI (2000). Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell. Moll. Neurobiol. 20: 217-230.
20. Saris SC, Wright DC, Oldfield EH, Blasberg RC (1988). Intravascular streaming and variable delivery to brain following carotid artery infusions in the Spraque-Dawley rat. J Cereb Blood Flow Metab. 8: 116-120. (Pubitemid 18045951)
21. Shapira Y, Artru AA, Yadid G, Shohami E (1992). Methylprednisolone does not decrease eicosanoid concentrations or edema in brain tissue or improve neurologic outcome after head trauma in rats. Anesth. Analg. 75: 238-244.
22. Schmued L, Slikker W (1999). Black-gold; a simple, high-resolution histochemical label for normal and pathological myelin in brain tissue sections, Brain Research. 837: 289-297. (Pubitemid 29369243)
23. Slivka PA, Murphy EJ (2001). High-dose methylprednisolone treatment in experimental focal cerebral ischemia. Exp. Neurol. 167: 166-172.
24. Stys PK (1998): Anoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics. J Cereb Blood Flow Metab. 18: 2-25.
25. Vajda Z, Promeneur D, Dóczi T ef al. (2000). Increased aquaporin-4 immunoreactivity in rat brain in response to systemic hyponatremia. Biochem Biophys Res Commun. 270: 495-503. (Pubitemid 30446864)
26. Yamaguchi M, Yamada T, Kinoshita I, Wu S, Nagashima T, Tamaki N (1997). Impaired learning of active avoidance in water-intoxicated rats. Acta Neurochir Suppl. 70: 152-4. (Pubitemid 127502079)