Bilirubin levels and redox status in a young healthy population

Acta Haematologica

Volumn 130, Issue 1, 2013, Pages 57-60

  Rodrigues, Carina ^a,d   Rocha, Susana ^a,b   Nascimento, Henrique ^a,b   Vieira, Emília ^c   Santos, Rosário ^c   Santos Silva, Alice ^a,b   Costa, Elísio ^a,b   Bronze Da Rocha, Elsa ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UP   (Portugal)

^d INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTIOXIDANT; BILIRUBIN; CHOLESTEROL; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE PROTEIN; THIOBARBITURIC ACID; TRIACYLGLYCEROL; GLUCURONOSYLTRANSFERASE; LOW DENSITY LIPOPROTEIN;

ALBUMIN BLOOD LEVEL; ALLELE; ARTICLE; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; ELECTROPHORESIS; ERYTHROCYTE; ERYTHROCYTE COUNT; GENE FREQUENCY; GENOTYPE; HEMATOCRIT; HEMATOLOGIC DISEASE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERBILIRUBINEMIA; IMMUNOBLOTTING; INFECTION; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER DISEASE; OXIDATIVE STRESS; PEROXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ADULT; BILIRUBIN BINDING; BLOOD BRAIN BARRIER; FEMALE; GENETIC TRANSCRIPTION; GILBERT DISEASE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; NORMAL HUMAN; OXIDATION REDUCTION STATE; PROTEIN DEGRADATION; YOUNG ADULT;

ADOLESCENT; ANTIOXIDANTS; BILIRUBIN; ERYTHROCYTES; FEMALE; GENOTYPE; GLUCURONOSYLTRANSFERASE; HUMANS; LIPID PEROXIDATION; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; REFERENCE VALUES; YOUNG ADULT;

EID: 84874801184     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000346429     Document Type: Article

References (10)

1. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP, Chowdhury NR: The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 117 1175
2. Bulmer AC, Blanchfield JT, Toth I, Fassett RG, Coornbes JS: Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. Atherosclerosis 2008; 199: 39 396
3. Brito A, Silva RF, Brites D: Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes. Cell Biol Toxicol 2002; 18: 18 192
4. Gopinathan V, Miller NJ, Milner AD, Rice- Evans CA: Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett 1994; 349: 197-200 (Pubitemid 24263261)
5. Arese P, Turrini F, Schwarzer E: Band 3/complement- mediated recognition and removal of normally senescent and pathological human erythrocytes. Cell Physiol Biochem 2005; 16: 133-146 (Pubitemid 41643014)
6. Costa E, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Sameiro-Faria S, Loureiro A, Quintanilha A, Belo L, Santos-Silva A: Band 3 profile as a marker of erythrocyte changes in chronic kidney disease patients. Open Clin Chem J 2008; 1: 57-63
7. Costa E, Vieira E, Dos Santos R: The polymorphism c.-3279T>G in the phenobarbital-responsive enhancer module of the bilirubin UDP- glucuronosyltransferase gene is associated with Gilbert syndrome. Clin Chem 2005; 51: 2204-2206 (Pubitemid 41532653)
8. Boon AC, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner KH, Bulmer AC: Reduced circulating LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic Biol Med 2012; 52: 2120-2127
9. Rodrigues C, Costa E, Vieira E, Carvalho J, Santos R, Rocha-Pereira P, Santos-Silva A, Bonze-da-Rocha E: Bilirubin is mainly dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index. Am J Med Sci 2012; 343: 114-118
10. Buyukasik Y, Akman U, Buyukasik NS, Goker H, Kilicarslan A, Shorbagi AI, Hascelik G, Haznedaroglu IC: Evidence for higher red blood cell mass in persons with unconjugated hyperbilirubinemia and Gilbert's syndrome. Am J Med Sci 2008; 335: 115-119. (Pubitemid 351253407) Tecnologia