메뉴 건너뛰기




Volumn 34, Issue 3, 2013, Pages 647-657

Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[ALPHA]ANTHRACENE; ANTHRACENE DERIVATIVE; CYCLIN D1; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCHRATOXIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

EID: 84874789152     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs368     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 0038424492 scopus 로고    scopus 로고
    • Task Force Report No. 139. Council of Agricultural Science and Technology. Council of Agricultural Science and Technology, Ames, IA
    • Council of Agricultural Science and Technology. (2003) Mycotoxins: Risks in Plant, Animal, and Human Systems. Task Force Report No. 139. Council of Agricultural Science and Technology, Ames, IA.
    • (2003) Mycotoxins: Risks in Plant, Animal, and Human Systems
  • 2
    • 0033921625 scopus 로고    scopus 로고
    • Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy
    • Vrabcheva, T. et al. (2000) Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy. J. Agric. Food Chem., 48, 2483-2488.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 2483-2488
    • Vrabcheva, T.1
  • 3
    • 0024723238 scopus 로고
    • Risk assessment of the mycotoxin ochratoxin A
    • Kuiper-Goodman, T. et al. (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci., 2, 179-248.
    • (1989) Biomed. Environ. Sci. , vol.2 , pp. 179-248
    • Kuiper-Goodman, T.1
  • 4
    • 13144293044 scopus 로고    scopus 로고
    • Ochratoxin A: the continuing enigma
    • O'Brien, E. et al. (2005) Ochratoxin A: the continuing enigma. Crit. Rev. Toxicol., 35, 33-60.
    • (2005) Crit. Rev. Toxicol. , vol.35 , pp. 33-60
    • O'Brien, E.1
  • 5
    • 33645462437 scopus 로고    scopus 로고
    • Conclusions from the workshops on ochratoxin A in food: recent developments and significance, organized by ILSI Europe in Baden (Austria)
    • Fink-Gremmels, J. (2005) Conclusions from the workshops on ochratoxin A in food: recent developments and significance, organized by ILSI Europe in Baden (Austria), 29 June-1 July 2005. Food Addit. Contam., 22 (suppl. 1), 1-5.
    • (2005) 29 June-1 July 2005. Food Addit. Contam. , vol.22 , Issue.SUPPL. 1 , pp. 1-5
    • Fink-Gremmels, J.1
  • 6
    • 84859785087 scopus 로고    scopus 로고
    • An update on direct genotoxicity as a molecular mechanism of ochratoxin A carcinogenicity
    • Pfohl-Leszkowicz, A. et al. (2012) An update on direct genotoxicity as a molecular mechanism of ochratoxin A carcinogenicity. Chem. Res. Toxicol., 25, 252-262.
    • (2012) Chem. Res. Toxicol. , vol.25 , pp. 252-262
    • Pfohl-Leszkowicz, A.1
  • 7
    • 33645469269 scopus 로고    scopus 로고
    • DNA adduct formation by ochratoxin A: review of the available evidence
    • Mally, A. et al. (2005) DNA adduct formation by ochratoxin A: review of the available evidence. Food Addit. Contam., 22 (suppl. 1), 65-74.
    • (2005) Food Addit. Contam. , vol.22 , Issue.SUPPL. 1 , pp. 65-74
    • Mally, A.1
  • 8
    • 33846454704 scopus 로고    scopus 로고
    • Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans
    • Pfohl-Leszkowicz, A. et al. (2007) Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol. Nutr. Food Res., 51, 61-99.
    • (2007) Mol. Nutr. Food Res. , vol.51 , pp. 61-99
    • Pfohl-Leszkowicz, A.1
  • 9
    • 34447551596 scopus 로고    scopus 로고
    • Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/N rats
    • Rached, E. et al. (2007) Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/N rats. Toxicol. Sci., 97, 288-298.
    • (2007) Toxicol. Sci. , vol.97 , pp. 288-298
    • Rached, E.1
  • 10
    • 34848837597 scopus 로고    scopus 로고
    • MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma
    • Marin-Kuan, M. et al. (2007) MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol. Appl. Pharmacol., 224, 174-181.
    • (2007) Toxicol. Appl. Pharmacol. , vol.224 , pp. 174-181
    • Marin-Kuan, M.1
  • 11
    • 75449115213 scopus 로고    scopus 로고
    • A journey through mitogen-activated protein kinase and ochratoxin A interactions
    • Rumora, L. et al. (2009) A journey through mitogen-activated protein kinase and ochratoxin A interactions. Arh. Hig. Rada Toksikol., 60, 449-456.
    • (2009) Arh. Hig. Rada Toksikol. , vol.60 , pp. 449-456
    • Rumora, L.1
  • 12
    • 3543129379 scopus 로고    scopus 로고
    • Chemical-induced DNA damage and human cancer risk
    • Poirier, M.C. (2004) Chemical-induced DNA damage and human cancer risk. Nat. Rev. Cancer, 4, 630-637.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 630-637
    • Poirier, M.C.1
  • 13
    • 79952253970 scopus 로고    scopus 로고
    • Molecular mechanisms of mouse skin tumor promotion
    • Rundhaug, J.E. et al. (2010) Molecular mechanisms of mouse skin tumor promotion. Cancers, 2, 436-482.
    • (2010) Cancers , vol.2 , pp. 436-482
    • Rundhaug, J.E.1
  • 14
    • 70249123827 scopus 로고    scopus 로고
    • Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications
    • Abel, E.L. et al. (2009) Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protocol., 4, 1350-1362.
    • (2009) Nat. Protocol. , vol.4 , pp. 1350-1362
    • Abel, E.L.1
  • 15
    • 84874778199 scopus 로고
    • Manual of Food Quality Control 10. Training in Mycotoxin Analysis. FAO. Food and Agriculture Organization of the United Nations, Rome
    • FAO. (1990) Food and Nutrition Paper 14/10, Manual of Food Quality Control 10. Training in Mycotoxin Analysis. Food and Agriculture Organization of the United Nations, Rome, pp. 4-10.
    • (1990) Food and Nutrition Paper 14/10 , pp. 4-10
  • 16
    • 84874765139 scopus 로고    scopus 로고
    • Evaluation of certain food additives and contaminants. WHO. Prepared by 49th meeting of JECFA. Geneva
    • WHO. (1998) Food Additives Series: No. 884, Evaluation of certain food additives and contaminants. Prepared by 49th meeting of JECFA. Geneva, pp. 357-468.
    • (1998) Food Additives Series: No. 884 , pp. 357-468
  • 17
    • 0032828082 scopus 로고    scopus 로고
    • Toxic effects of mycotoxins in humans
    • Peraica, M. et al. (1999) Toxic effects of mycotoxins in humans. Bull. World Health Organ., 77, 754-766.
    • (1999) Bull. World Health Organ. , vol.77 , pp. 754-766
    • Peraica, M.1
  • 18
    • 84864819165 scopus 로고    scopus 로고
    • Human skin penetration of selected model mycotoxins
    • Boonen, J. et al. (2012) Human skin penetration of selected model mycotoxins. Toxicology, 301, 21-32.
    • (2012) Toxicology , vol.301 , pp. 21-32
    • Boonen, J.1
  • 19
    • 47049092139 scopus 로고    scopus 로고
    • The significance of mycotoxins in the framework of assessing workplace-related hazards
    • Mayer, S. et al. (2007) The significance of mycotoxins in the framework of assessing workplace-related hazards. Gefahrstoffe Reinhalt Luft, 67, 407-417.
    • (2007) Gefahrstoffe Reinhalt Luft , vol.67 , pp. 407-417
    • Mayer, S.1
  • 20
    • 79961149226 scopus 로고    scopus 로고
    • Tools for investigating workplace-related risks from mycotoxin exposure
    • Degen, G.H. (2011) Tools for investigating workplace-related risks from mycotoxin exposure. World Mycotoxin J., 4, 315-327.
    • (2011) World Mycotoxin J , vol.4 , pp. 315-327
    • Degen, G.H.1
  • 21
    • 10844291411 scopus 로고
    • Ochratoxin A: a review
    • Pohland, A.E. et al. (1992) Ochratoxin A: a review. Pure Appl. Chem., 64, 1029-1045.
    • (1992) Pure Appl. Chem. , vol.64 , pp. 1029-1045
    • Pohland, A.E.1
  • 22
    • 84867385968 scopus 로고    scopus 로고
    • Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin
    • Kumar, R. et al. (2012) Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin. PLoS ONE, 7, e47280.
    • (2012) PLoS ONE , vol.7
    • Kumar, R.1
  • 23
    • 0018355087 scopus 로고
    • Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion
    • Verma, A.K. et al. (1979) Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion. Cancer Res., 39, 419-425.
    • (1979) Cancer Res , vol.39 , pp. 419-425
    • Verma, A.K.1
  • 24
    • 0026543367 scopus 로고
    • Status of ornithine decarboxylase activity and DNA synthesis in mancozeb-exposed mouse skin
    • Gupta, K.P. et al. (1992) Status of ornithine decarboxylase activity and DNA synthesis in mancozeb-exposed mouse skin. Carcinogenesis, 13, 131-133.
    • (1992) Carcinogenesis , vol.13 , pp. 131-133
    • Gupta, K.P.1
  • 25
    • 83455225538 scopus 로고    scopus 로고
    • In vitro studies on immunotoxic potential of Orange II in splenocytes
    • Yadav, A. et al. (2012) In vitro studies on immunotoxic potential of Orange II in splenocytes. Toxicol. Lett., 208, 239-245.
    • (2012) Toxicol. Lett. , vol.208 , pp. 239-245
    • Yadav, A.1
  • 26
    • 84863418499 scopus 로고    scopus 로고
    • Detection of ochratoxin A in wheat samples in different regions of India
    • Kumar, R. et al. (2012) Detection of ochratoxin A in wheat samples in different regions of India. Food Control, 26, 63-67.
    • (2012) Food Control , vol.26 , pp. 63-67
    • Kumar, R.1
  • 27
    • 0016158553 scopus 로고
    • Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro
    • Yuspa, S.H. et al. (1974) Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp. Cell Res., 86, 95-105.
    • (1974) Exp. Cell Res. , vol.86 , pp. 95-105
    • Yuspa, S.H.1
  • 28
    • 0025953532 scopus 로고
    • A multicentre study of acute in vitro cytotoxicity in rat liver cells
    • Fautrel, A. et al. (1991) A multicentre study of acute in vitro cytotoxicity in rat liver cells. Toxicol. In Vitro, 5, 543-547.
    • (1991) Toxicol. In Vitro , vol.5 , pp. 543-547
    • Fautrel, A.1
  • 29
    • 81855185490 scopus 로고    scopus 로고
    • Role of mitogen activated protein kinases in skin tumorigenicity of patulin
    • Saxena, N. et al. (2011) Role of mitogen activated protein kinases in skin tumorigenicity of patulin. Toxicol. Appl. Pharmacol., 257, 264-271.
    • (2011) Toxicol. Appl. Pharmacol. , vol.257 , pp. 264-271
    • Saxena, N.1
  • 30
    • 79952253970 scopus 로고    scopus 로고
    • Molecular mechanisms of mouse skin tumor promotion
    • Rundhaug, J.E. et al. (2010) Molecular mechanisms of mouse skin tumor promotion. Cancers, 2, 436-482.
    • (2010) Cancers , vol.2 , pp. 436-482
    • Rundhaug, J.E.1
  • 31
    • 0009506830 scopus 로고
    • Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion
    • Slaga, T.J. et al. (1980) Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion. Proc. Natl. Acad. Sci. U.S.A., 77, 3659-3663.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 3659-3663
    • Slaga, T.J.1
  • 32
    • 0017072855 scopus 로고
    • The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis
    • O'Brien, T.G. (1976) The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis. Cancer Res., 36, 2644-2653.
    • (1976) Cancer Res , vol.36 , pp. 2644-2653
    • O'Brien, T.G.1
  • 33
    • 0026779333 scopus 로고
    • Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene
    • Halmekytö, M. et al. (1992) Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene. Biochem. Biophys. Res. Commun., 187, 493-497.
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 493-497
    • Halmekytö, M.1
  • 34
    • 27644555091 scopus 로고    scopus 로고
    • Cyclooxygenase-2: how good is it as a target for cancer chemoprevention? Eur
    • Hull, M.A. (2005) Cyclooxygenase-2: how good is it as a target for cancer chemoprevention? Eur. J. Cancer, 41, 1854-1863.
    • (2005) J. Cancer , vol.41 , pp. 1854-1863
    • Hull, M.A.1
  • 35
    • 0028940248 scopus 로고
    • Early overexpression of cyclin D1 protein in mouse skin carcinogenesis
    • Robles, A.I. et al. (1995) Early overexpression of cyclin D1 protein in mouse skin carcinogenesis. Carcinogenesis, 16, 781-786.
    • (1995) Carcinogenesis , vol.16 , pp. 781-786
    • Robles, A.I.1
  • 36
    • 0034642509 scopus 로고    scopus 로고
    • Deregulated expression of cyclin D1 overrides antimitogenic signals
    • Martinez, L.A. et al. (2000) Deregulated expression of cyclin D1 overrides antimitogenic signals. Oncogene, 19, 315-322.
    • (2000) Oncogene , vol.19 , pp. 315-322
    • Martinez, L.A.1
  • 37
    • 50349092829 scopus 로고    scopus 로고
    • Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferation
    • Ansari, K.M. et al. (2008) Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferation. Mol. Cancer Res., 6, 1003-1016.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1003-1016
    • Ansari, K.M.1
  • 38
    • 0032529165 scopus 로고    scopus 로고
    • Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
    • Robles, A.I. et al. (1998) Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev., 12, 2469-2474.
    • (1998) Genes Dev , vol.12 , pp. 2469-2474
    • Robles, A.I.1
  • 39
    • 0037096879 scopus 로고    scopus 로고
    • Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    • Tiano, H.F. et al. (2002) Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res., 62, 3395-3401.
    • (2002) Cancer Res , vol.62 , pp. 3395-3401
    • Tiano, H.F.1
  • 40
    • 0035861689 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction
    • Chen, N. et al. (2001) Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction. J. Biol. Chem., 276, 46722-46728.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46722-46728
    • Chen, N.1
  • 41
    • 0037012011 scopus 로고    scopus 로고
    • Functional roles of Akt signaling in mouse skin tumorigenesis
    • Segrelles, C. et al. (2002) Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene, 21, 53-64.
    • (2002) Oncogene , vol.21 , pp. 53-64
    • Segrelles, C.1
  • 42
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon, A.S. et al. (2007) MAP kinase signalling pathways in cancer. Oncogene, 26, 3279-3290.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1
  • 43
    • 0032541677 scopus 로고    scopus 로고
    • Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis
    • Porter, A.C. et al. (1998) Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene, 16, 1343-1352.
    • (1998) Oncogene , vol.16 , pp. 1343-1352
    • Porter, A.C.1
  • 44
    • 0347997608 scopus 로고    scopus 로고
    • MAPK signal pathways in the regulation of cell proliferation in mammalian cells
    • Zhang, W. et al. (2002) MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res., 12, 9-18.
    • (2002) Cell Res , vol.12 , pp. 9-18
    • Zhang, W.1
  • 45
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson, G.L. et al. (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science, 298, 1911-1912.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1
  • 46
    • 3042522892 scopus 로고    scopus 로고
    • Stress-activated protein kinases-tumor suppressors or tumor initiators?
    • Engelberg, D. (2004) Stress-activated protein kinases-tumor suppressors or tumor initiators? Semin. Cancer Biol., 14, 271-282.
    • (2004) Semin. Cancer Biol. , vol.14 , pp. 271-282
    • Engelberg, D.1
  • 47
    • 34547838415 scopus 로고    scopus 로고
    • Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-κB and AP-1: IκB kinase as respective potential upstream targets
    • Lee, J.C. et al. (2007) Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-κB and AP-1: IκB kinase as respective potential upstream targets. Carcinogenesis, 28, 1491-1498.
    • (2007) Carcinogenesis , vol.28 , pp. 1491-1498
    • Lee, J.C.1
  • 48
    • 0025734065 scopus 로고
    • TPA-induced activation of MAP kinase
    • Adams, P.D. et al. (1991) TPA-induced activation of MAP kinase. FEBS Lett., 290, 77-82.
    • (1991) FEBS Lett , vol.290 , pp. 77-82
    • Adams, P.D.1
  • 49
    • 33645072441 scopus 로고    scopus 로고
    • p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis
    • Bourcier, C. et al. (2006) p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res., 66, 2700-2707.
    • (2006) Cancer Res , vol.66 , pp. 2700-2707
    • Bourcier, C.1
  • 50
    • 66349138173 scopus 로고    scopus 로고
    • p38δ mitogen-activated protein kinase is essential for skin tumor development in mice
    • Schindler, E.M. et al. (2009) p38δ mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res., 69, 4648-4655.
    • (2009) Cancer Res , vol.69 , pp. 4648-4655
    • Schindler, E.M.1
  • 51
    • 0035872409 scopus 로고    scopus 로고
    • Suppression of skin tumorigenesis in c-Jun NH2-terminal kinase-2-deficient mice
    • Chen, N. et al. (2001) Suppression of skin tumorigenesis in c-Jun NH2-terminal kinase-2-deficient mice. Cancer Res., 61, 3908-3912.
    • (2001) Cancer Res , vol.61 , pp. 3908-3912
    • Chen, N.1
  • 52
    • 0030906497 scopus 로고    scopus 로고
    • AP-1 function and regulation
    • Karin, M. et al. (1997) AP-1 function and regulation. Curr. Opin. Cell Biol., 9, 240-246.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 240-246
    • Karin, M.1
  • 53
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-kappaB: players, pathways, perspectives
    • Gilmore, T.D. (2006) Introduction to NF-kappaB: players, pathways, perspectives. Oncogene, 25, 6680-6684.
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 54
    • 20344381337 scopus 로고    scopus 로고
    • Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives
    • Surh, Y.J. et al. (2005) Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives. Arch. Pharm. Res., 28, 1-15.
    • (2005) Arch. Pharm. Res. , vol.28 , pp. 1-15
    • Surh, Y.J.1
  • 55
    • 0033539885 scopus 로고    scopus 로고
    • Increased expression of p50-NF-κB and constitutive activation of NF-nB transcription factors during mouse skin carcinogenesis
    • Budunova, I.V. et al. (1999) Increased expression of p50-NF-κB and constitutive activation of NF-nB transcription factors during mouse skin carcinogenesis. Oncogene, 18, 7423-7431.
    • (1999) Oncogene , vol.18 , pp. 7423-7431
    • Budunova, I.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.