Relationship between virus-neutralizing antibody levels and the number of rabies vaccinations: A prospective study of dogs in Japan

Japanese Journal of Infectious Diseases

Volumn 66, Issue 1, 2013, Pages 17-21

  Watanabe, Ippei ^a   Yamada, Kentaro ^b   Aso, Akira ^c   Suda, Okio ^d   Matsumoto, Takashi ^a   Yahiro, Takaaki ^a   Ahmed, Kamruddin ^b   Nishizono, Akira ^a  

^a Faculty of Medicine   (Japan)

^b OITA UNIVERSITY   (Japan)

^c Oita City Medical Association   (Japan)

^d Suda Veterinary Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; RABIES VACCINE; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; DOG; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; INFECTION CONTROL; INFECTION PREVENTION; JAPAN; MALE; NONHUMAN; PROSPECTIVE STUDY; RABIES; RABIES VACCINATION; RABIES VIRUS; SEROPREVALENCE; VACCINATION; VIRUS NEUTRALIZATION; VIRUS STRAIN; ANIMAL; BLOOD; DOG DISEASES; IMMUNIZATION; IMMUNOLOGY; STATISTICS AND NUMERICAL DATA; VETERINARY; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; DOG DISEASES; DOGS; FEMALE; IMMUNIZATION SCHEDULE; JAPAN; MALE; PROSPECTIVE STUDIES; RABIES; RABIES VACCINES; RABIES VIRUS; VACCINATION;

EID: 84874786227     PISSN: 13446304     EISSN: 18842836     Source Type: Journal    
DOI: 10.7883/yoken.66.17     Document Type: Article

References (23)

1. World Health Organization (WHO) (2005): WHO Expert Consultation on rabies. 7.2 Canine mass parenteral vaccination campaigns. WHO Tech. Rep. Ser., 931, 29-36.
2. Inoue, S. (2005): Rabies contingency plan in Japan. Jpn. J. Clin. Med., 63, 2180-2186 (in Japanese).
3. Onda, H. (1968): Rabies control in Japan. Bull. Off. Int. Epizoot., 69, 249-251.
4. Takahashi-Omoe, H., Omoe, K. and Okabe, N. (2008): Regulatory systems for prevention and control of rabies, Japan. Emerg. Infect. Dis., 14, 1368-1374.
5. Takayama, N. (2000): Rabies control in Japan. Jpn. J. Infect. Dis., 53, 93-97.
6. Shimazaki, Y., Inoue, S., Takahashi, C, et al. (2003): Immune response to Japanese rabies vaccine in domestic dogs. J. Vet. Med. B. Infect. Dis. Vet Public Health, 50, 95-98.
7. Smith, J.S., Yager, P.A. and Baer, G.M. (1973): A rapid reproducible test for determining rabies neutralizing antibody. Bull. World Health Organ., 48, 535-541.
8. Zavadova, J., Svrcek, S., Madar, M., et al. (1996): Titration of rabies antibodies with the rapid fluorescence focus inhibition test. Vet. Med. (Praha), 41, 225-230.
9. Kahn, S., Stuardo, L. and Rahman, S.A. (2008): OIE guidelines on dog population control. Dev. Biol. (Basel), 131, 511-516.
10. Edwards, S. (2007): OIE standards for vaccines and future trends. Rev. Sci. Tech., 26, 373-378.
11. Minke, J., Bouvet, J., Cliquet, F., et al. (2009): Comparison of antibody responses after vaccination with two inactivated rabies vaccines. Vet. Microbiol., 133, 283-286.
12. Hiromi, Y., Morimasa, Y., Shinsuke, E., et al. (2008): Antibody levels of dogs vaccinated with Japanese inactivated tissue culture rabies vaccine and their antibody responses after re-vaccination. J. Jpn.Vet. Med. Assoc, 61, 311-314.
13. Rogers, C.L. (2011): Rabies vaccination compliance following introduction of the triennial vaccination interval-the Texas experience. Zoonoses Public Health, 58, 229-233.
14. Shiota, S., Mannen, K., Matsumoto, T., et al. (2009): Development and evaluation of a rapid neutralizing antibody test for rabies. J. Virol. Methods, 161, 58-62.
15. Nishizono, A., Yamada, K., Khawplod, P., et al. (2012): Evaluation of an improved rapid neutralizing antibody detection kit (RAPINA) for qualitative and semiquantitative detection of rabies neutralizing antibody in humans and dogs. Vaccine, 30, 3891-3896.
16. Ministry of Health, Labour and Welfare of Japan: Number of Regiestered Dogs and Number of Rabies Vaccinated Dogs in Japan (1960-2011). Online at (in Japanese).
17. Japan Pet Food Association: Rate, Average Number, and Total Number of Dogs/Cats Kept at Home in Japan. Online at (in Japanese).
18. National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry & Fisheries of Japan: Sales Amount of Medicines, Quasi-Drugs and Medical Devices for Animal Use, 2011. Online at
19. Ministry of the Environment of Japan: Number of Dog Bite Cases in Japan (1974-2009). Online at (in Japanese).
20. Ogawa, T., Gamoh, K., Kanda, K et al. (2009): Rabies immune status of dogs brought into the Hyogo Prefecture Animal Wellbeing Center, Japan. J. Vet. Med. Sci., 71, 825-826.
21. Seghaier, C, Cliquet, F., Hammami, S., et al. (1999): Rabies mass vaccination campaigns in Tunisia: are vaccinated dogs correctly immunized?. Am. J. Trop. Med. Hyg., 61, 879-884.
22. Lawson, K.F. and Crawley, J.F. (1972): The ERA strain of rabies vaccine. Can. J. Comp. Med., 36, 339-344.
23. Aghomo, H.O., Oduye, O.O. and Rupprecht, C.E. (1990): The serological response of young dogs to the Flury LEP strain of rabies virus vaccine. Vet. Res. Commun., 14, 415-425.