A case of hypersensitivity to mosquito bites without peripheral natural killer cell lymphocytosis in a 6-year-old Korean boy

Journal of Korean Medical Science

Volumn 28, Issue 1, 2013, Pages 164-166

  Seon, Han Su ^a   Roh, Ji Hyeon ^a   Lee, Seung Ho ^a   Kang, Eun Kyeong ^a  

^a Dongguk University Ilsan Hospital   (South Korea)

Author keywords

Epstein barr virus; Hypersensitivity; Mosquito bites; Natural killer cell

Indexed keywords

ARTICLE; CASE REPORT; CHILD; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; INSECT BITE; LYMPHOCYTOSIS; MALE; MOSQUITO BITES; NATURAL KILLER CELL; PATHOLOGY; SKIN; SOUTH KOREA;

EPSTEIN-BARR VIRUS; HYPERSENSITIVITY; MOSQUITO BITES; NATURAL KILLER CELL;

CHILD; EPSTEIN-BARR VIRUS INFECTIONS; HUMANS; HYPERSENSITIVITY; INSECT BITES AND STINGS; KILLER CELLS, NATURAL; LYMPHOCYTOSIS; MALE; REPUBLIC OF KOREA; SKIN;

EID: 84874782173     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2013.28.1.164     Document Type: Article

References (13)

1. Tokura Y, Ishihara S, Tagawa S, Seo N, Ohshima K, Takigawa M. Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma. J Am Acad Dermatol 2001; 45: 569-78.
2. Chung JS, Shin HJ, Lee EY, Cho GJ. Hypersensitivity to mosquito bites associated with natural killer cell-derived large granular lymphocyte lymphocytosis: a case report in Korea. Korean J Intern Med 2003; 18: 50-2.
3. Cho JH, Kim HS, Ko YH, Park CS. Epstein-Barr virus infected natural killer cell lymphoma in a patient with hypersensitivity to mosquito bite. J Infect 2006; 52: e173-6.
4. Roh EJ, Chung EH, Chang YP, Myoung NH, Jee YK, Seo M, Kang JH. A case of hypersensitivity to mosquito bite associated with Epstein-barr viral infection and natural killer cell lymphocytosis. J Korean Med Sci 2010; 25: 321-3.
5. Kimura H, Hoshino Y, Kanegane H, Tsuge I, Okamura T, Kawa K, Morishima T. Clinical and virologic characteristics of chronic active Epstein- Barr virus infection. Blood 2001; 98: 280-6.
6. Pacheco SE, Gottschalk SM, Gresik MV, Dishop MK, Okmaura T, McCormick TG. Chronic active Epstein-Barr virus infection of natural killer cells presenting as severe skin reaction to mosquito bites. J Allergy Clin Immunol 2005; 116: 470-2.
7. Kimura H, Hoshino Y, Hara S, Sugaya N, Kawada J, Shibata Y, Kojima S, Nagasaka T, Kuzushima K, Morishima T. Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. J Infect Dis 2005; 191: 531-9.
8. Cohen JI, Jaffe ES, Dale JK, Pittaluga S, Heslop HE, Rooney CM, Gottschalk S, Bollard CM, Rao VK, Marques A, et al. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood 2011; 117: 5835-49.
9. Satoh M, Oyama N, Akiba H, Ohtsuka M, Iwatsuki K, Kaneko F. Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis: the possible implication of Epstein-Barr virus reactivation. Eur J Dermatol 2002; 12: 381-4.
10. Zhang Z, Shi Q, An X, Ma H, Zhou H, Ma J, Zhou X. NK/T-cell lymphoma in a child with hypersensitivity to mosquito bites. J Pediatr Hematol Oncol 2009; 31: 855-7.
11. Asada H. Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and oncogenesis. J Dermatol Sci 2007; 45: 153-60.
12. Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikuta A, Sawada A, et al. EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. Blood 2012; 119: 673-86.
13. Kawa K, Sawada A, Sato M, Okamura T, Sakata N, Kondo O, Kimoto T, Yamada K, Tokimasa S, Yasui M, et al. Excellent outcome of allogeneic hematopoietic SCT with reduced-intensity conditioning for the treatment of chronic active EBV infection. Bone Marrow Transplant 2011; 46: 77-83