CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells expressing CD99: A diagnostic challenge in a country non-endemic for human T-cell leukemia virus

Pathology International

Volumn 63, Issue 2, 2013, Pages 132-137

  Lin, Tsung Hsien ^a   Wu, Hung Chang ^a   Hsieh, Yen Chuan ^a,b   Tseng, Chih En ^c   Ichinohasama, Ryo ^e   Chuang, Shih Sung ^a,d  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adult T cell leukemia lymphoma; CD4; CD8; CD99; Human T cell lymphotropic virus; Taiwan

Indexed keywords

BETAMETHASONE; CD3 ANTIGEN; CD30 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD99 ANTIGEN; CYCLOPHOSPHAMIDE; EPIRUBICIN; INTERLEUKIN 2 RECEPTOR ALPHA; VINCRISTINE; VIRUS DNA;

ADULT; ARTICLE; CASE REPORT; CELL INFILTRATION; FEMALE; HUMAN; HUMAN T CELL LEUKEMIA VIRUS; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPH NODE BIOPSY; MULTIPLE CYCLE TREATMENT; PANCYTOPENIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; SOUTHERN BLOTTING; T CELL LEUKEMIA; TAIWAN;

ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, CD8; BIOPSY; CELL ADHESION MOLECULES; DIAGNOSTIC ERRORS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LEUKEMIA-LYMPHOMA, ADULT T-CELL; MIDDLE AGED; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 84874774424     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12040     Document Type: Article

References (27)

1. Ohshima K, Jaffe ES, Kikuchi M. Adult T-cell leukemia/lymphoma. In: Swerdlow SH, Campo E, Harris NL etal., eds. WHO Classification of Tumours of Haemtopoietic and Lymphoid Tissues. Lyon: IARC, 2008; 281-284.
2. Suh YH, Shin YK, Kook MC etal. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. Gene 2003; 307: 63-76.
3. Sung CO, Ko YH, Park S etal. Immunoreactivity of CD99 in non-Hodgkin's lymphoma: unexpected frequent expression in ALK-positive anaplastic large cell lymphoma. J Korean Med Sci 2005; 20: 952-956.
4. Gordon MD, Corless C, Renshaw AA etal. CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis. Mod Pathol 1998; 11: 769-773.
5. Pelosi G, Fraggetta F, Sonzogni A etal. CD99 immunoreactivity in gastrointestinal and pulmonary neuroendocrine tumours. Virchows Arch 2000; 437: 270-274.
6. Choi YL, Chi JG, Suh YL. CD99 immunoreactivity in ependymoma. Appl Immunohistochem Mol Morphol 2001; 9: 125-129.
7. Lucas DR, Bentley G, Dan ME etal. Ewing sarcoma vs lymphoblastic lymphoma. A comparative immunohistochemical study. Am J Clin Pathol 2001; 115: 11-17.
8. Pelmus M, Guillou L, Hostein I etal. Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases. Am J Surg Pathol 2002; 26: 1434-1440.
9. Hsieh Y-C, Chang ST, Huang W-T etal. A comparative study of flow cytometric T-cell receptor Vβ repertoire and T-cell receptor gene rearrangement in the diagnosis of large granular lymphocytic lymphoproliferation. Int J Lab Hematol 2013; doi:10.1111/ijlh.12041. In press.
10. Shih LY, Liang DC. Non-Hodgkin's lymphomas in Asia. Hematol Oncol Clin North Am 1991; 5: 983-1001.
11. Lu SC, Chen BH. Seroindeterminate HTLV-1 prevalence and characteristics in blood donors in Taiwan. Int J Hematol 2003; 77: 412-413.
12. Chang ST, Hsieh YC, Kuo SY etal. The spectrum of T-cell and natural killer/T-cell neoplasms with leukaemic presentation in a single institution in Taiwan. Int J Lab Hematol 2012; 34: 422-426.
13. Ohshima K, Suzumiya J, Sugihara M etal. Clinical, immunohistochemical and phenotypic features of aggressive nodal cytotoxic lymphomas, including alpha/beta, gamma/delta T-cell and natural killer cell types. Virchows Arch 1999; 435: 92-100.
14. Kamihira S, Sohda H, Atogami S etal. Phenotypic diversity and prognosis of adult T-cell leukemia. Leuk Res 1992; 16: 435-441.
15. Sato E, Tokunaga M, Hasui K etal. Pathoepidemiological features of adult T-cell lymphoma/leukemia in an endemic area: Kagoshima, Japan. Cancer Detect Prev 1990; 14: 423-429.
16. Yamada Y, Kamihira S, Amagasaki T etal. Changes of adult T cell leukemia cell surface antigens at relapse or at exacerbation phase after chemotherapy defined by use of monoclonal antibodies. Blood 1984; 64: 440-444.
17. Kamihira S, Sohda H, Atogami S etal. Unusual morphological features of adult T-cell leukemia cells with aberrant immunophenotype. Leuk Lymphoma 1993; 12: 123-130.
18. Suzushima H, Asou N, Nishimura S etal. Double-negative (CD4- CD8-) T cells from adult T-cell leukemia patients also have poor expression of the T-cell receptor alpha beta/CD3 complex. Blood 1993; 81: 1032-1039.
19. Suzushima H, Asou N, Hattori T etal. Adult T-cell leukemia derived from S100 beta positive double-negative (CD4- CD8-) T cells. Leuk Lymphoma 1994; 13: 257-262.
20. Shimauchi T, Hirokawa Y, Tokura Y. Purpuric adult T-cell leukaemia/lymphoma: expansion of unusual CD4/CD8 double-negative malignant T cells expressing CCR4 but bearing the cytotoxic molecule granzyme B. Br J Dermatol 2005; 152: 350-352.
21. Yamada Y, Kamihira S, Amagasaki T etal. Adult T cell leukemia with atypical surface phenotypes: clinical correlation. J Clin Oncol 1985; 3: 782-788.
22. Ferrara F, Cimino R, Antinolfi I etal. Clinical relevance of immunological dissection in T-ALL: a report on 20 cases with stem cell (CD7+, CD4-, CD8-, CD1-) phenotype. Am J Hematol 1992; 40: 98-102.
23. Terada T. TDT (-), KIT (+), CD34 (+), CD99 (+) precursor T lymphoblastic leukemia/lymphoma. Int J Clin Exp Pathol 2012; 5: 167-170.
24. Zhang PJ, Barcos M, Stewart CC etal. Immunoreactivity of MIC2 (CD99) in acute myelogenous leukemia and related diseases. Mod Pathol 2000; 13: 452-458.
25. Robertson PB, Neiman RS, Worapongpaiboon S etal. 013 (CD99) positivity in hematologic proliferations correlates with TdT positivity. Mod Pathol 1997; 10: 277-282.
26. Gorczyca W. Flow Cytometry in Neoplastic Hematology. Morphologic-Immunophenotypic Correlation. London: Informa UK Ltd, 2006.
27. Jamal S, Picker LJ, Aquino DB etal. Immunophenotypic analysis of peripheral T-cell neoplasms. A multiparameter flow cytometric approach. Am J Clin Pathol 2001; 116: 512-526.