Neutrophils usher monocytes into sites of inflammation

Circulation Research

Volumn 112, Issue 5, 2013, Pages 744-745

  Swirski, Filip K ^a   Robbins, Clinton S ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

cathelicidin; chemokine; inflammation; monocyte; neutrophil; recruitment

Indexed keywords

ALPHA4 INTEGRIN; CATHELICIDIN; CD11B ANTIGEN; CD18 ANTIGEN; CHEMOKINE RECEPTOR CXCR2; GAMMA INTERFERON; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

CELL ACTIVATION; CELL ADHESION; EDITORIAL; ENDOTHELIUM CELL; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL COMMUNICATION; HUMANS; INFLAMMATION; MONOCYTES; NEUTROPHILS;

EID: 84874770943     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.300867     Document Type: Editorial

References (8)

1. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678-689.
2. Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339:161-166.
3. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204:3037-3047.
4. Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med. 2003;9:61-67.
5. Postea O, Vasina EM, Cauwenberghs S, Projahn D, Liehn EA, Lievens D, Theelen W, Kramp BK, Butoi ED, Soehnlein O, Heemskerk JW, Ludwig A, Weber C, Koenen RR. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia. Arterioscler Thromb Vasc Biol. 2012;32:1186-1193.
6. Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res. 2012;110:875-888.
7. Wantha S, Alard JE, Megens RT, et al. Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res. 2013;112:792-801.
8. Döring Y, Drechsler M, Wantha S, Kemmerich K, Lievens D, Vijayan S, Gallo RL, Weber C, Soehnlein O. Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Res. 2012;110:1052-1056.