Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis

Oncogene

Volumn 32, Issue 10, 2013, Pages 1338-

  Wagner, K U ^a   Booth, B W ^b   Boulanger, C A ^c   Smith, G H ^c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CLEMSON UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; BETA GALACTOSIDASE; CANCER GROWTH FACTOR; CYCLIN D1; TRANSFORMING GROWTH FACTOR BETA;

BREAST CANCER; BREAST EPITHELIUM; LETTER; MOUSE MAMMARY TUMOR ONCOVIRUS; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TUMOR MICROENVIRONMENT; VIRUS CARCINOGENESIS;

ANIMALS; FEMALE; HUMANS; INTEGRIN ALPHA6; INTEGRIN BETA3; NEOPLASTIC STEM CELLS; RECEPTOR, ERBB-2; TRANSFORMING GROWTH FACTOR BETA;

MOUSE MAMMARY TUMOR VIRUS;

EID: 84874768475     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.452     Document Type: Letter

References (6)

1. Lo PK, Kanojia D, Liu X, Singh UP, Berger FG, Wang Q et al. CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFb signaling. Oncogene 2012; 31: 2614-2626.
2. Henry MD, Triplett AA, Oh KB, Smith GH, Wagner KU. Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice. Oncogene 2004; 23: 6980-6985.
3. Matulka LA, Triplett AA, Wagner KU. Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Dev Biol 2007; 303: 29-44.
4. Boulanger CA, Wagner KU, Smith GH. Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression. Oncogene 2005; 24: 552-560.
5. Booth BW, Boulanger CA, Anderson L, Smith GH. The mammary microenvironment restricts the tumorigenic phenotype of MMTV- neu-Transformed tumor cells. Oncogene 2011; 30: 679-689.
6. Jeselsohn R, Brown NE, Arendt L, Klebba I, Hu MG, Kuperwasser C et al. Cyclin D1 kinase activity is required for the self- renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell 2010; 17: 65-76.