Dopaminergic cells, derived from a high efficiency differentiation protocol from umbilical cord derived mesenchymal stem cells, alleviate symptoms in a Parkinson's disease rodent model

Cell Biology International

Volumn 37, Issue 2, 2013, Pages 167-180

  Shetty, Prathibha ^a   Thakur, Anirban M ^a   Viswanathan, Chandra ^a  

^a RELIANCE LIFE SCIENCES PVT LTD   (India)

Author keywords

Mesenchymal stem cells; Parkinson's disease; Umbilical cord

Indexed keywords

NUCLEAR RECEPTOR RELATED FACTOR 1; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL ISOLATION; CELL SURVIVAL; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DOPAMINERGIC NERVE CELL; GENE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; IMMUNOGENICITY; IMMUNOMODULATION; IN VIVO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; RAT; SSEA4 GENE; SYMPTOMATOLOGY;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; UMBILICAL CORD;

EID: 84874740862     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10029     Document Type: Article

References (39)

1. Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105: 1815-1822.
2. Augello A, Tasso R,Negrini SM, Amateis A, Indiveri F, Cancedde R, Pennesi G (2005) Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of programmed death 1 pathway. Eur J Immunol 35: 1482-1490.
3. Baksh D, Song L, Tuan RS (2004) Adult mesenchymal stem cells: characterization, differentiation and, application in cell and gene therapy. J Cell Mol Med 8: 301-316.
4. Barnabé GF, Schwindt TT, Calcagnotto ME,Motta FL, Martinez G, Jr, de Oliveira AC, Keim LMN, D'almeida V, Mendez Otero R, Mello LE (2009) Chemically-induced RAT mesenchymal stem cells adopt molecular properties of neuronal-like cells but do not have basic neuronal functional properties. PLoS ONE 4: e5222.
5. Blondheim NR, Levy YS, Ben-Zur T, Burshtein A, Cherlow T, Kan I, Barzilai R, Bahat-stromzaM, Barhum Y, Bulvi S,Maelamed E, Offen D (2006) Human mesenchymal stem cells express neural genes, suggesting a neural predisposition. Stem Cells Dev 15: 141-164.
6. Bonaguidi MA, Peng CY, Mcguire T, Falciglia G, Gobeske KT, Czeisler C, Kessler JA (2008) Noggin expands the adult stem cells in adult hippocampus. J Neurosci 28: 9194-9204.
7. Cova L, Armentero MT, Zennaro E, Calzarossa C, Bossalasco P, Busca G, Lambertenghi DG, Polli E, Nappi G, Silani V, Blandini F (2010) Multiple neurogenic and neurorescue effects of mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease. Brain Res 1311: 12-27.
8. Datta I, Mishra S, Mohanty L, Pulikkot S, Joshi P (2011) Neuronal plasticity of humanWarton's jelly mesenchymal stromal cells to the dopaminergic cell type compared with the human bone marrow mesenchymal stromal cells. Cytotherapy 13: 918-932.
9. Deng J, Petersen BE, Steindler DA, Jorgensen ML, Laywell ED (2006) Mesenchymal stem cells spontaneously express neural proteins in culture, and are neurogenic after transplantation. Stem Cells 24: 1054-1064.
10. Fu YS, Cheng YC, Lin MY, Cheng H, Chu PM, Chou SC, Shih YH, Ko MH, Sung MS (2006) Conversion of umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: Potential therapeutic application for Parkinsonism. Stem Cells 24: 115-124.
11. Ganz J, Lev N, Melamed E, Offen D (2011) Cell replacement therapy for Parkinson's disease, how close are we to the clinic? Expert Rev Neurother 11: 1325-1339
12. Haobam R, Sindhu KM, Chandra G, Mohanakumar KP (2005) Swim test as a function of motor impairment in aMPTP model of Parkinson's disease: a comparative study in two mouse strains. Behav Brain Res 163: 159-167.
13. Hellmann MA, Panet H, Barhum Y, Melamed E, Offen D (2006) Increased survival and migration of engrafted mesenchymal stem cells in 6-hydroxydopamine-lesioned rodents. Neurosci Lett 395: 124-128.
14. Levy YS, Stroomza MB, Barzilay R, Burshtein A, Bulvik S, Barhum Y, Panet H, Melamed E, Offen D (2008) Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease. Cytotherapy 10: 340-352.
15. Li M, Zhang SZ, Guo YW, Cai YQ, Yan ZJ, Zou Z, Jiang XD, Ke YQ, He XY, Jin ZL, Lu GH, Su DQ (2010) Human umbilical vein-derived dopaminergic-like cell transplantation with nerve growth factor ameliorates motor dysfunction in a rat model of Parkinson's disease. Neurochem Res 35(10): 1522-1529.
16. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D (2004) Human bone marrow stromal cells inhibit allogeneic T cell responses by indoleamine 2,3-dioxygenase mediated tryptophan degradation. Blood 103: 4619-4621.
17. Mitchell KE,Weiss ML,Mitchell BM,Martin P, DavisD,Morales L, Helwig B, Beerenstrauch M, Abou-Easa K, Hildreth T, Troyer D, Medicetty S (2003) Matrix cells from Wharton's jelly forms neurons and glia. Stem Cells 21: 50-60.
18. Morrison SJ (2001) Stem cell potential. Curr Biol 11: R7-R9.
19. Neuhuber B, Gallo G, Howard L, Kostura L, Mackay A, Fischer I (2004) Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype. J Neurosci Res 77: 192-204.
20. Nikenejad H, Peirovi H, Amadiani A, Ghanavi J, Jorjani M (2010) Differentiation factors that influence neuronal markers expression in vitro from human amniotic epithelial cells. Eur Cells Mater 19: 22-29.
21. Ravindran G, Ramnath RL, Rao HS, Viswanathan C (2008) One year survival and significant reversal of motor deficits in Parkinsonian rat's transplanted with hESC derived dopaminergic neurons. Biochem Biophys Res Commun 373: 258-364.
22. Rocky ST, Genevieve B, Richard T (2002) Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 5: 32-45.
23. Sarugaser R, Lickorish D, Baksh D, Hosseini MM, Davies JE (2005) Human umbilical perivascular cells (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells 23: 220-229.
24. Sheng H,Wang Y, Jin Y, Zhang Q, Zhang Y,Wang L, Shen B, Yin S, Liu W, Cui L, Ningli L (2008) A critical role of IFNg priming MSC-mediated suppression of T cell proliferation through up regulation of B7-H1, Cell Res 18: 846-857
25. Shetty P, Ravindran G, Sarang S, Thakur AM, Rao HS, Viswanathan C (2009) Clinical grade mesenchymal stem cells transdifferentiated under xenofree conditions alleviates motor deficiencies in a rat model with Parkinson's disease. Cell Biol Int 33: 830-838.
26. Shetty P, Cooper K, Viswanathan C (2010) Comparison of proliferative and multilineage differentiation potential of cord matrix, cord blood and bone morrow mesenchymal stem cells. Asian J Transfus Sci 4: 14-24.
27. Singaravelu K, Padanilam BJ (2009) In vitro differentiation of MSC into cells with a renal tubular epithelial-like phenotype. Ren Fail 31: 492-502.
28. Soun S, Yang M, Lacovitti L (2006) Human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease. Brain Res 1106: 46-51.
29. Synkers S, Kock J, De Rogiers V, Vanhaecke T (2009) In vitro differentiation of embryonic and adult stem cells into hepatocytes. Stem Cells 27: 577-605.
30. Tartad VM, D'Ippolito GS, Diabira S, Valeyev A, Hackman J, McCarthy M, Bouckenooghe T, Menei P, Montero-Menei CN, Schiller PC (2007) Neurotrophic-directed differentiation of human adult marrow stromal cells to dopaminergic-like neurons. Bone 40: 360-373.
31. Tipnis S, Viswanathan C (2010) Umbilical cord matrix derived mesenchymal stem cells can change the cord transplant scenario. Int J Stem Cells 3: 103-118.
32. Tipnis S, Viswanathan C, SenMajumdar A (2010) Immunosuppressive properties of human umbilical cord derived mesenchymal stem cells role of B7-H1 and IDO. Immunol Cell Biol 88: 795-806.
33. Tondreau T, Lagneaux L, Dejeneffe M, Massy M, Mortier C, Delforge A, Bron D (2004) Bone marrow-derived mesenchymal stem cells already express specific neural proteins before any differentiation. Differentiation 72: 319-326.
34. Trzaska KA, Kuzhikhandatil EV, Rameshwar P (2007) Specification of dopaminergic phenotype from adult human mesenchymal stem cells. Stem Cells 25: 2797-2808.
35. Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S, Luo Y, Rao MS, Velageleti G, Troyer D (2006) Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells 24: 781-792.
36. Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, Vander Werff I, Troyer D, McIntosh KR (2008) Immune properties of human umbilical cord Wharton's jelly derived cells. Stem Cells 26: 1-9.
37. Woodbury D, Reynolds K, Black IB (2002) Adult bone marrow stromal cells express germline, ectodermal, endodermal and mesodermal genes prior to neurogenesis. J Neurosci Res 96: 902-917.
38. Xiong N, Zhang Z, Huang J, Chen C, Zhang Z, Jia M, Xiong J, Liu X,Wang F, Cao X, Liang Z, Sun S, Lin Z,Wang T (2011) VEGFexpressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Therapy 18: 394-402.
39. Ye M,Wang XJ, Zhang YH, Guo-Qiang L, Liang L, Jie-Yi X, Sheng-Di C (2007) Transplantation of bone marrow stromal cells containing the neuturin gene in rat model of Parkinson's disease. Brain Res 1142: 206-216.