Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans

Biochemical Pharmacology

Volumn 85, Issue 7, 2013, Pages 881-887

  Cadicamo, Cosimo D ^a   Mortier, Jérémie ^a   Wolber, Gerhard ^a   Hell, Marie ^a   Heinrich, Ina E ^a   Michel, Dana ^a   Semlin, Lydia ^b   Berger, Ursula ^b   Korting, Hans C ^b   Höltje, Hans Dieter ^a   Koksch, Beate ^a   Borelli, Claudia ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anti virulence agent; Candida albicans; Candidapeptidase; Pepstatin; Peptidomimetic; Secreted aspartic proteinases inhibition

Indexed keywords

ANTIFUNGAL AGENT; ASPARTIC PROTEINASE; PEPSTATIN DERIVATIVE;

ANTIFUNGAL RESISTANCE; ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ASPARTIC ACID ENDOPEPTIDASES; CANDIDA ALBICANS; DRUG DESIGN; FUNGAL PROTEINS; ISOENZYMES; MODELS, MOLECULAR; PEPSTATINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84874667823     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.12.008     Document Type: Article

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