Analogues of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects
Zoja, C. et al. Analogues of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects. Am. J. Physiol. Renal Physiol. http://dx.doi.org/doi:10.1152/ajprenal.00376.2012.
Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARgamma, and HO-1
Wu, Q. Q. et al. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARgamma, and HO-1. Am. J. Physiol. Renal Physiol. 300, F1180-F1192 (2011).
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity
Aleksunes, L. M. et al. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J. Pharmacol. Exp. Ther. 335, 2-12 (2010).
Reata Pharmaceuticals. Company Statement: Termination of the BEACON Trial [online], http://www.reatapharma.com/investors-media/news/news-timeline/2012/ company-statement-termination-of-beacon-trial.aspx (2012).
Reduction in albuminuria predicts a beneficial effect on diminishing the progression of human diabetic nephropathy during antihypertensive treatment
Rossing, P., Hommel, E., Smidt, U. M. & Parving, H.-H. Reduction in albuminuria predicts a beneficial effect on diminishing the progression of human diabetic nephropathy during antihypertensive treatment. Diabetologia 37, 511-516 (1994).