Subthreshold depression in older subjects: An unmet therapeutic need

Journal of Nutrition, Health and Aging

Volumn 16, Issue 10, 2012, Pages 909-913

  Cherubini, Antonio ^a,b,m   Nistico, G ^c   Rozzini, R ^d,m   Liperoti, R ^e,m   Di Bari, M ^f,m   Zampi, E ^b,m   Ferrannini, L ^g,n   Aguglia, E ^h,n   Pani, L ^i,j   Bernabei, R ^e,k,l   Marchionni, N ^f,m   Trabucchi, M ^k,l,o  

^a INRCA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c European Brain Research Institute (EBRI)   (Italy)

^d Fondazione Poliambulanza   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

^f UNIVERSITY OF FLORENCE   (Italy)

^g ASL 3   (Italy)

^h UNIVERSITY OF CATANIA   (Italy)

ⁱ INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^j ITALIAN MEDICINES AGENCY   (Italy)

^k UNIVERSITY OF ROME TOR VERGATA   (Italy)

^l GERIATRIC RESEARCH GROUP   (Italy)

^m Italian Society of Gerontology and Geriatrics (SIGG)   (Italy)

ⁿ Young Section SIP Giovani   (Italy)

^o Italian Association of Psychogeriatrics (AIP)   (Italy)

more..

Author keywords

depressive symptoms; older subject; Subthreshold depression; underdiagnosis; undertreatment

Indexed keywords

ANTIDEPRESSANT AGENT; PLACEBO;

ARTICLE; COGNITIVE THERAPY; CONSENSUS; DEATH; DEPRESSION; DISABILITY; DSM-IV; ELDERLY CARE; EVIDENCE BASED MEDICINE; HEALTH CARE NEED; HEALTH STATUS; HUMAN; MAJOR DEPRESSION; MORBIDITY; MORTALITY; PRIORITY JOURNAL; PSYCHOLOGICAL WELL BEING; PSYCHOTHERAPY; QUALITY OF LIFE; SUBTHRESHOLD DEPRESSION;

EID: 84874652082     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-012-0373-9     Document Type: Article

References (70)

1. Mecocci P.; Cherubini A.; Mariani E.; Ruggiero C, Senin U. Depression in the elderly: new concepts and therapeutic approaches. Aging Clin Exper Res 2004;16:176-189. (Pubitemid 39232487)
2. Alexopoulos GS. Depression in the elderly. Lancet 2005;365:1961-1970. (Pubitemid 40797508)
3. Massimo Musicco, Angelo Bianchetti, Carlo Caltagirone, Patrizia Mecocci, Elvezio Pirfo, Gianfranco Salvioli, Umberto Senin, Marco Trabucchi, Claudio Vampini. Il trattamento della depressione nell'anziano. Documento di consenso della associazione italiana di psicogeriatria. Psicogeriatria 2007; suppl. 1:1-41. http://www.psicogeriatria.it/usr-files/pubblicazioni/riviste/supp-1- 2007.pdf Accessed on March 1, 2011.
4. Mulsant BH, Ganguli M. J Clin Psychiatry. Epidemiology and diagnosis of depression in late life. 1999:60Suppl 20:9-15. (Pubitemid 29468384)
5. Unützer J. Clinical practice. Late-life depression. N Engl J Med 2007;357:2269-2276. (Pubitemid 350190757)
6. Gottfries CG. Is there a difference between elderly and younger patients with regard to the symptomatology and aetiology of depression? Int Clin Psychopharmacol. 1998;13Suppl 5:S13-S18.
7. Roeloffs C, Sherbourne C, et.al. Stigma and depression among primary care patients. Gen Hosp Psychiatry 2003;25:311-315. (Pubitemid 37102937)
8. Gallo JJ, Anthony JC, et.al Age differences in the symptoms of depression: a latent trait analysis. J Gerontol B Psychol Sci Soc Sci 1994;49:251-264.
9. Lyness IM, Cox C, et al Older age and the underreporting of depressive symptoms. J Am Geriatr Soc 1995;43:216-221.
10. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (Revised 4th ed.). Washington, DC: 2000.
11. Meeks TW, Vahia IV, Lavretsky H, Kulkarni G, Jeste DV. A tune in "a minor" can "b major": A review of epidemiology, illness course, and public health implications of subthreshold depression in older adults. J Affect Disord. 2011:129:126-142
12. NIH consensus conference. Diagnosis and treatment of depression in late life. JAMA. 1992;268:1018-1024
13. Beekman AT, Geerlings SW, Deeg DJ, Smit JH, Schoevers RS, de Beurs E, Braam AW, Penninx BW, van Tilburg W. The natural history of late-life depression: a 6-year prospective study in the community. Arch Gen Psychiatry. 2002;59:605-611. (Pubitemid 34747240)
14. Cui, X.; Lyness, J.M.; Tang, W.; Tu, X.; Conwell, Y. Outcomes and predictors of late-life depression trajectories in older primary care patients. Am. J. Geriatr. Psychiatry 2008;16,406415.
15. Lyness, J.M.; Chapman, B.P.; McGriff, J.; Drayer, R.; Duberstein, P.R. Oneyear outcomes of minor and subsyndromal depression in older primary care patients. Int. Psyehogeriatr. 2009;21, 60-68.
16. Wells KB, Stewart A, Hays RD, Burnam MA, Rogers W, Daniels M, Berry S, Greenfield S, Ware J. The functioning and well being of depressed patients. Results from the Medical Outcomes Study. JAMA. 1989;262:914-919 (Pubitemid 19208948)
17. Broadhead WE, Blazer DG, George LK, Tse CK. Depression, disability days, and days lost from work in a prospective epidemiologic survey. JAMA. 1990;264:2524-2528.
18. Beekman ATE, Deeg DJH, Braam AW, Smit JH, van Tilburg W. Consequences of major and minor depression in later life: a study of disability, well-being and service utilization. Psychol Med. 1997;27:1397-1409. (Pubitemid 27494105)
19. Amore M.; Tagariello P.; Laterza C. and Savoia E.M. Beyond nosography of depression in elderly. Arch. Gerontol. Geriatr. Suppl. 1 (2007) 13-22 (Pubitemid 46273707)
20. Beekman AT, de Beurs E, van Balkom AJ, Deeg DJ, van Dyck R, van Tilburg W. Anxiety and depression in later life: Co-occurrence and communality of risk factors. Am J Psychiatry. 2000;157:89-95. (Pubitemid 30027426)
21. King Kallimanis B, Gum AM, Kohn R. Comorbidity of depressive and anxiety disorders for older Americans in the national comorbidity survey-replication. Am J Geriatr Psychiatry. 2009;17:782-792.
22. Wolitzky-Taylor KB, Castriotta N, Lenze EJ, Stanley MA, Craske MG. Anxiety disorders in older adults: a comprehensive review.Depress Anxiety. 2010;27:190-211.
23. Koenig HG, George LK, Peterson BL, Pieper CF. Depression in medically ill hospitalized older adults: prevalence, characteristics, and course of symptoms according to six diagnostic schemes. Am J Psychiatry. 1997;154:1376-1383. (Pubitemid 27415604)
24. Krishnan KR, Delong M, Kraemer H, Carney R, Spiegel D, Gordon C, McDonald W, Dew M, Alexopoulos G, Buckwalter K, Cohen PD, Evans D, Kaufmann PG, Olin J, Otey E, Wainscott C. Comorbidity of depression with other medical diseases in the elderly. Biol Psychiatry. 2002;52:559-588. (Pubitemid 35284022)
25. Cepoiu M, McCusker J, Cole MG, Sewitch M, Ciampi A. Recognition of depression in older medical inpatients. J Gen Intern Med. 2007;22:559-564. (Pubitemid 46941180)
26. Lyness, J.M.; King, D.A.; Cox, C.; Yoediono, Z.; Caine, E.D. The importance of subsyndromal depression in older primary care patients: prevalence and associated functional disability. J. Am. Geriatr. Soc. 1999;47, 647-652. (Pubitemid 29266629)
27. Heun, R.; Papassotiropoulos, A.; Ptok, U. Subthreshold depressive and anxiety disorders in the elderly. Eur. Psychiatry 2000;15, 173-182 (Pubitemid 30350553)
28. Murphy, J.M.; Nierenberg, A.A.; Laird, N.M.; Monson, R.R.; Sobol, A.M.; Leighton, A.H.;. Incidence of major depression: prediction from subthreshold categories in the Stirling County Study. J. Affect. Disord. 2002;68:251-259. (Pubitemid 34628332)
29. Judd, L.L.; Rapaport, M.H.; Paulus, M.P.; Brown, J.L. Subsyndromal symptomatic depression: a new mood disorder? J. Clin. Psychiatry 1994:55(Suppl), 18-28. (Pubitemid 24135964)
30. Lavretsky, H.; Kumar, A. Clinically significant non-major depression: old concepts, new insights. Am. J. Geriatr. Psychiatry 2002;10, 239-255. (Pubitemid 34517677)
31. Lyness, J.M.; Kim, J.; Tang, W.; Tu, X.; Conwell, Y.; King, D.A.; Caine, E.D. The clinical significance of subsyndromal depression in older primary care patients. Am. J. Geriatr. Psychiatry 2007;15, 214-223.
32. Beekman, A.T.; Deeg, D.I.; van Tilburg, T.; Smit, J.H.; Hooijer, C.; van Tilburg, W. Major and minor depression in later life: a study of prevalence and risk factors. J. Affect. Disord. 1995;36, 65-75. (Pubitemid 26020975)
33. Maercker, A.; Forstmeier, S.; Enzler, A.; Krusi, G.; Horler, E.; Maier, C.; Ehlert, U. Adjustment disorders, posttraumatic stress disorder, and depressive disorders in old age: findings from a community survey. Compr. Psychiatry 2008;49, 113-120.
34. Cohen, C.L.; Magai, C.; Yaffee, R.; Walcott-Brown, L. Racial differences in syndromal and subsyndromal depression in an older urban population. Psychiatr. Serv. 2005;56, 1556-1563. (Pubitemid 41790116)
35. Vahia, I.V.; Meeks, T.W.; Thompson, W.K.; Depp, CA.; Zisook, S.; Allison, M.; Judd, L.L.; Jeste, D.V. Subthreshold depression and successful aging in older women. Am. J. Geriatr. Psychiatry 2010;18, 212-220.
36. Hybels, C.F.; Blazer, D.G.; Pieper, C.F. Toward a threshold for subthreshold depression: an analysis of correlates of depression by severity of symptoms using data from an elderly community sample. Gerontologist 2001;41, 357-365. (Pubitemid 32525552)
37. Morrow-Howell, N.; Proctor, E.; Choi, S.; Lawrence, L.; Brooks, A.; Hasche, L.; Dore, P.; Blinne, W. Depression in public community long-term care: implications for intervention development. J. Behav. Health Serv. Res. 2008;35, 37-51.
38. Parmelee, P.A.; Katz, LR.; Lawton, M.P. Depression among institutionalized aged: assessment and prevalence estimation. J. Gerontol. 1989;44, M22-M29.
39. Jongenelis, K.; Pot, A.M.; Fisses, A.M.; Beekman, A.T.; Kluiter, H.; Ribbe, M.W. Prevalence and risk indicators of depression in elderly nursing home patients: the AGED study. L Affect. Disord. 2004;83, 135-142. (Pubitemid 39536187)
40. Licht-Strunk, E.; van der Kooij, K.G.; van Schaik, D.I.; van Marwijk, H.W.; van Hout, H.P.; de Haan, M.; Beekman, A.T. Prevalence of depression in older patients consulting their general practitioner in The Netherlands. Int. J. Geriatr. Psychiatry 2005;20, 1013-1019. (Pubitemid 41723571)
41. Chen, CS.; Chong, M.Y.; Tsang, H.Y. Clinically significant non-major depression in a community-dwelling elderly population: epidemiological findings. Int. J. Geriatr. Psychiatry 2007;22, 557-562. (Pubitemid 46951754)
42. Conwell, Y. Suicide in later life: A review and recommendations for prevention. Suicide and Life Threatening Behavior 2001;31(suppl):32-47. (Pubitemid 32327959)
43. Alexopoulos GS, et al. Assessment of late-life depression. Biol Psychiatry 2002;52:164-174. (Pubitemid 35232085)
44. Alexopoulos GS, Katz IR, Reynolds CF 3rd, Carpenter D, Docherty LP; Expert Consensus Panel for Pharmacotherapy of Depressive Disorders in Older Patients. The expert consensus guideline series: pharmacotherapy of depressive disorders in older patients. Postgrad Med Special Report 2001; Spec No Pharmacotherapy, October: 1-86
45. Goldberg D. Plato versus Aristotle: categorical and dimensional models for common mental disorders. Compr Psychiatry. 2000;41(Suppl 1):8-13. (Pubitemid 30146628)
46. Rowe SK, Rapaport MH. Classification and treatment of sub-threshold depression. Curr Opin Psychiatry 2006;19:9-13. (Pubitemid 44406138)
47. Lyness, J.M.; Heo, M.; Datto, C.L.; Ten Have, T.R.; Katz, I.R.; Drayer, R.; Reynolds III, C.F.; Alexopoulos, G.S.; Bruce, M.L. Outcomes of minor and subsyndromal depression among elderly patients in primary care settings. Ann. Intern. Med. 2006;144, 496-504. (Pubitemid 46780672)
48. Hegel MT, Oxman TE, Hull JG, Swain K, Swick H. Watchful waiting for minor depression in primary care: remission rates and predictors of improvement. Gen Hosp Psychiatry. 2006;28:205-212.
49. Broadhead WE, Blazer DG, George LK, Tse CK. Depression, disability days, and days lost from work in a prospective epidemiologic survey. JAMA. 1990;264:2524-2528.
50. Cuijpers, P.; Beekman, A.; Smit, F.; Deeg, D. Predicting the onset of major depressive disorder and dysthymia in older adults with subthreshold depression: a community based study. Int. J. Geriatr. Psychiatry 2006;21, 811-818. (Pubitemid 44492552)
51. Schoevers, RA.; Smit, F.; Deeg, D.J.; Cuijpers, P.; Dekker, J.; van Tilburg, W.; Beekman, A.T. Prevention of late-life depression in primary care: do we know where to begin? Am. J. Psychiatry 2006;163, 1611-1621. (Pubitemid 44465763)
52. Penninx BW, Geerlings SW, Deeg DJ, van Eijk JT, van TW, Beekman AT. Minor and major depression and the risk of death in older persons. Arch Gen Psychiatry 1999;56:889-895. (Pubitemid 29480124)
53. Hybels, C.F.; Pieper, C.F.; Blazer, D.G. The complex relationship between depressive symptoms and functional limitations in community-dwelling older adults: the impact of subthreshold depression. Psychol. Med. 2009;9, 112.
54. Grabovich A.; Lu N.; Tang W.; Tu X.; Lyness J. Outcomes of Subsyndromal Depression in Older Primary Care Patients. American Journal of Geriatric Psychiatry. 2010;18:227-235
55. Han, L.; McCusker, J.; Cole, M.; Abrahamowicz, M.; Capek, R. 12-month cognitive outcomes of major and minor depression in older medical patients. Am. J. Geriatr. Psychiatry 2008;16, 742-751.
56. Boyle, L.L.; Porsteinsson, A.P.; Cui, X.; King, D.A.; Lyness, J.M. Depression predicts cognitive disorders in older primary care patients. J. Clin. Psychiatry 2010;71, 74-79.
57. Cuijpers P, Smit F, van Straten A. Psychological treatments of subthreshold depression: a meta-analytic review. Acta Psychiatr Scand. 2007;115:434-441. (Pubitemid 46733702)
58. Mossey JM, Knott KA, Higgins M, Talerico K. Effectiveness of a psychosocial intervention, interpersonal counseling, for subdysthymic depression in medically ill elderly. J Gerontol Med Sci 1996;51A:M172-M178.
59. Haringsma R, Engels GI, Cuijpers P, Spinhoven P. Effectiveness of the coping with depression (CWD) course for older adults provided by the community-based mental health care system in the Netherlands: a randomized controlled field trial. Int Psychogeriatr 2006;18:307-325. (Pubitemid 43829880)
60. Lamers F, Jonkers CC, Bosnia H, Kempen GI, Meijer JA, Penninx BW, Knottnerus JA, van Eijk JT. A minimal psychological intervention in chronically ill elderly patients with depression: a randomized trial. Psychother Psychosom. 2010;79:217-226.
61. Barbui C, Cipriani A, Patel V, Ayuso-Mateos JL, van Ommeren M. Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis. Br J Psychiatry. 2011:198(suppl. 1):11-16.
62. Williams Jr, JW, Barrett J, Oxman T, Frank E, Katon W, Sullivan M, et al. Treatment of dysthymia and minor depression in primary care: a randomized controlled trial in older adults. JAMA 2000;284:1519-1526.
63. Burrows AB, Salzman C, Satlin A, Noble K, Pollock BG, Gersh T. A randomized, placebo-controlled trial of paroxetine in nursing home residents with non-major depression. Depress Anxiety 2002;15:102-110. (Pubitemid 34522470)
64. Williams JW Jr, Rost K, Dietrich AJ, Ciotti MC, Zyzanski SJ, Cornell Primary care physicians' approach to depressive disorders. Effects of physician specialty and practice structure. Arch Fam Med. 1999;8:58-67.
65. Percudani M, Barbui C, Fortino I, Petrovich L. Antidepressant drug prescribing among elderly subjects: a population-based study. Int J Geriatr Psychiatry. 2005;20:113-118. (Pubitemid 40277889)
66. Olfson M, Marcus SC. National patterns in antidepressant medication treatment. Arch Gen Psychiatry. 2009;66:848-856.
67. Demyttenaere K, Bonnewyn A, Bruffaerts R, De Girolamo G, Gasquet I, Kovess V Haro JM, Alonso J. Clinical factors influencing the prescription of antidepressants and benzodiazepines: results from the European study of the epidemiology of mental disorders (ESEMeD). J Affect Disord. 2008;110:84-93.
68. Habicht DW, Witham MD, McMurdo ME. The under representation of older people in clinical trials: barriers and potential solutions. J. Nutr Health Aging. 2008;12:194-196. (Pubitemid 351450117)
69. Cherubini A.; Del Signore S.; Ouslander J.; Semla T.; Michel JP. Fighting against age discrimination in clinical trials. Journal of the American Geriatrics Society 2010;58:1791-1796.
70. Cherubini A.; Oristrell J, Pia X, Ruggiero C, Ferretti R, Diestre G, Clarfield AM, Crome P, Hertogh C, Lesauskaite V, Prada GI, Szczerbinska K, Topinkova E, Sinclair Cohen J, Edbrooke D, Mills GH. The persistent exclusion of older subjects from ongoing trials on heart failure. Arch Intern Med 2011:171:550-556.