MiRNAs regulate stem cell self-renewal and differentiation

Frontiers in Genetics

Volumn 3, Issue SEP, 2012, Pages

  Yu, Zuoren ^a   Li, Yuan ^a   Fan, Huimin ^a   Liu, Zhongmin ^a   Pestell, Richard G ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Epigenetic modification; MicroRNA; Self renewal; Stem cell

Indexed keywords

EID: 84874642698     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00191     Document Type: Article

References (45)

1. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., and Clarke, M. F. (2003). Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100, 3983-3988.
2. Anokye-Danso, F., Trivedi, C. M., Juhr, D., Gupta, M., Cui, Z., Tian, Y., Zhang, Y., Yang, W., Gruber, P. J., Epstein, J. A., and Morrisey, E. E. (2011). Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8, 376-388.
3. Bartel, D. P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
4. Braconi, C., Huang, N., and Patel, T. (2010). MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 51, 881-890.
5. Card, D. A., Hebbar, P. B., Li, L., Trotter, K. W., Komatsu, Y., Mishina, Y., and Archer, T. K. (2008). Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 28, 6426-6438.
6. Chang, H. M., Martinez, N. J., Thornton, J. E., Hagan, J. P., Nguyen, K. D., and Gregory, R. I. (2012). Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat. Commun. 3, 923.
7. Draper, J. S., Moore, H. D., Ruban, L. N., Gokhale, P. J., and Andrews, P. W. (2004). Culture and characterization of human embryonic stem cells. Stem Cells Dev. 13,325-336.
8. Eger, A., Aigner, K., Sonderegger, S., Dampier, B., Oehler, S., Schreiber, M., Berx, G., Cano, A., Beug, H., and Foisner,R. (2005).DeltaEF1 isatran-scriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24, 2375-2385.
9. Esquela-Kerscher,A.,Trang, P., Wiggins, J. F., Patrawala, L., Cheng, A., Ford, L., Weidhaas, J. B., Brown, D., Bader, A. G., and Slack, F. J. (2008). The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 7, 759-764.
10. Garchow, B. G., Bartulos Encinas, O., Leung, Y T., Tsao, P. Y., Eisenberg, R. A., Caricchio, R., Obad, S., Petri, A., Kauppinen, S., and Kiriakidou, M. (2011). Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol. Med. 3, 605-615.
11. Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., Melamed, N., Bentwich, Z., Hod, M., Goren, Y., and Chajut, A. (2008). Serum microRNAs are promising novel biomarkers. PLoS ONE 3, e3148. doi: 10.1371/journal.pone.0003148
12. Godlewski, J., Nowicki, M. O., Bronisz, A., Williams, S., Otsuki, A., Nuovo, G., Raychaudhury, A., Newton, H. B., Chiocca, E. A., and Lawler, S. (2008). Targeting of the Bmi-1oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 68, 9125-9130.
13. Jaenisch, R., and Young, R. (2008). Stem cells, the molecular circuitry of pluripotency andnuclear reprogramming. Cell 132, 567-582.
14. Ji, Q., Hao, X., Zhang, M., Tang, W., Yang, M., Li, L., Xiang, D., Desano, J. T., Bommer, G. T., Fan, D., Fearon, E. R., Lawrence, T. S., and Xu, L. (2009). MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS ONE 4, e6816. doi: 10.1371/journal.pone.0006816
15. Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., Livingston, D. M., and Rajewsky, K. (2005). Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19, 489-501.
16. Kosaka, N., Iguchi, H., and Ochiya, T. (2010). Circulating microRNA in body fluid: anewpotentialbiomarker for cancer diagnosis and prognosis. Cancer Sci. 101,2087-2092.
17. Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H. W., Chang, T. C., Vivekanandan, P., Torbenson, M., Clark, K. R., Mendell, J. R., and Mendell, J. T. (2009). Therapeutic microRNA delivery suppresses tumorigenesis in amurineliver cancer model. Cell 137, 1005-1017.
18. Krutovskikh, V., and Partensky, C. (2011). New insights in oncology: epigenetics and cancer stem cells. Cancer Radiother. 15, 716-722.
19. Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., and Dick, J. E. (1994). A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648.
20. Liep, J., Rabien, A., and Jung, K. (2012). Feedback networks between microRNAs and epigenetic modifications in urological tumors. Epigenetics 7, 315-325.
21. Lin, S. L., Chang, D. C., Chang-Lin, S., Lin, C. H., Wu, D. T., Chen, D. T., andYing,S.Y (2008).Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 14,2115-2124.
22. Liu, C., Kelnar, K., Vlassov, A. V., Brown, D., Wang, J., and Tang, D. G. (2012). Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7. Cancer Res. 72, 3393-3404.
23. Liu, C., and Tang, D. G. (2011). MicroRNA regulation of cancer stem cells. Cancer Res. 71, 5950-5954.
24. Liu, S., Dontu, G., Mantle, I. D., Patel, S., Ahn, N. S., Jackson, K. W., Suri, P., and Wicha, M. S. (2006). Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 66,6063-6071.
25. Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez-Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., Gallagher, W M., Eccles, S. A., Croce, C. M., and Esteller, M. (2008). A microRNA DNA methylation signature for human cancer metastasis. Proc. Natl. Acad. Sci. U.S.A. 105, 13556-13561.
26. Lujambio, A., Ropero, S., Ballestar, E., Fraga, M. F., Cerrato, C., Setién, F., Casado, S., Suarez-Gauthier, A., Sanchez-Cespedes, M., Git, A., Spiteri, I., Das, P. P., Caldas, C., Miska, E., and Esteller, M. (2007). Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 67, 1424-1429.
27. Mullenix, P. S., Huddleston, S. J., Stojadinovic, A., Trachiotis, G. D., and Alexander, E. P. (2012). A new heart: somatic stem cells and myocardial regeneration. J. Surg. Oncol. 105, 475-480.
28. Noonan, E. J., Place, R. F., Pookot, D., Basak, S., Whitson, J. M., Hirata, H., Giardina, C., and Dahiya, R. (2009). miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene 28, 1714-1724.
29. Qian, S., Ding, J. Y., Xie, R., An, J. H., Ao, X. J., Zhao, Z. G., Sun, J. G., Duan, Y Z., Chen, Z. T., and Zhu, B. (2008). MicroRNA expression profile of bronchioalveolar stem cells from mouse lung. Biochem. Biophys. Res. Commun. 377, 668-673.
30. Rivera, S., Rivera, C., Loriot, Y., Hennequin, C., Vozenin, M. C., and Deutsch, E. (2011). Cancer stem cells: a new target for lung cancer treatment. Cancer Radiother. 15, 355-364.
31. Rosen, J. M., and Jordan, C. T. (2009). The increasing complexity of the cancer stem cell paradigm. Science 324,1670-1673.
32. Saito, Y., and Jones, P. A. (2006). Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 5, 2220-2222.
33. Shimono, Y., Zabala, M., Cho, R. W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S. P., Chiao, E., Dirbas, F. M., Somlo, G., Pera, R. A., Lao, K., and Clarke, M. F. (2009). Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138, 592-603.
34. Singh, S. K., Clarke, I. D., Terasaki, M., Bonn, V. E., Hawkins, C., Squire, J., and Dirks, P. B. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5821-5828.
35. Sotiropoulou, G., Pampalakis, G., Lianidou, E., and Mourelatos, Z. (2009). Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA 15, 1443-1461.
36. Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
37. Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., Mitsudomi, T., and Takahashi, T. (2004). Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64, 3753-3756.
38. Tay, Y., Zhang, J., Thomson, A. M., Lim, B., and Rigoutsos, I. (2008). MicroRNAs to Nanog, Oct4 andSox2 coding regions modulate embryonic stem cell differentiation. Nature 455, 1124-1128.
39. Velasco-Velazquez, M. A., Homsi, N., De La Fuente, M., and Pestell, R. G. (2012). Breast cancer stem cells. Int. J. Biochem. Cell Biol. 44, 573-577.
40. Wiklund, E. D., Gao, S., Hulf, T., Sibbritt, T., Nair, S., Costea, D. E., Villadsen, S. B., Bakholdt, V., Bramsen, J. B., Sørensen, J. A., Krogdahl, A., Clark, S. J., and Kjems, J. (2011). MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. PLoS ONE 6, e27840. doi: 10.1371/journal.pone.0027840
41. Wiklund, E. D., Kjems, J., and Clark, S. J. (2010). Epigenetic architecture and miRNA: reciprocal regulators. Epigenomics 2, 823-840.
42. Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J. A., and Kosik, K. S. (2009). MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137, 647-658.
43. Ye, L., Chang, J. C., Lin, C., Sun, X., Yu, J., and Kan, Y W. (2009). Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A. 106, 9826-9830.
44. Yu, F., Yao, H., Zhu, P., Zhang, X., Pan, Q., Gong, C., Huang, Y., Hu, X., Su, F., Lieberman, J., and Song, E. (2007). let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131, 1109-1123.
45. Zhu, S., Si, M. L., Wu, H., and Mo, Y. Y. (2007). MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).J. Biol.Chem. 282, 14328-14336.