Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Cannuyer, Julie ^a   Loriot, Axelle ^a   Parvizi, Grégory K ^a   De Smet, Charles ^a  

^a DE DUVE INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE 1; HYGROMYCIN; MELANOMA ANTIGEN 1; TRICHOSTATIN A; HISTONE; MAGEA1 PROTEIN, HUMAN; MELANOMA ANTIGEN;

ARTICLE; CANCER CELL CULTURE; CELL CLONE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DRUG TARGETING; EPIGENETICS; GAIN OF FUNCTION MUTATION; GENE ACTIVATION; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC CORRELATION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MAGEA1 GENE; MELANOMA; MELANOMA CELL; PROMOTER REGION; SENSITIVITY ANALYSIS; TRANSGENE; CELL LINE; CPG ISLAND; GENETIC EPIGENESIS; GENETICS; METABOLISM; NEOPLASM; REPORTER GENE; SKIN TUMOR; TUMOR CELL LINE;

CELL LINE; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HISTONES; HUMANS; MELANOMA; MELANOMA-SPECIFIC ANTIGENS; NEOPLASMS; PROMOTER REGIONS, GENETIC; SKIN NEOPLASMS; TRANSGENES;

EID: 84874641922     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058743     Document Type: Article

References (39)

1. Bird A, (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21.
2. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP, (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72: 141-196.
3. Esteller M, (2008) Epigenetics in cancer. N Engl J Med 358: 1148-1159.
4. Ehrlich M, (2002) DNA methylation in cancer: too much, but also too little. Oncogene 21: 5400-5413.
5. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science 300: 489-492.
6. De Smet C, Loriot A, (2010) DNA hypomethylation in cancer: epigenetic scars of a neoplastic journey. Epigenetics 5: 206-213.
7. Loriot A, Boon T, De Smet C, (2003) Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. Int J Cancer 105: 371-376.
8. Almeida LG, Sakabe NJ, deOliveira AR, Silva MC, Mundstein AS, et al. (2009) CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens. Nucleic Acids Res 37: D816-819.
9. Van Der Bruggen P, Zhang Y, Chaux P, Stroobant V, Panichelli C, et al. (2002) Tumor-specific shared antigenic peptides recognized by human T cells. Immunol Rev 188: 51-64.
10. Boon T, Coulie PG, Van den Eynde BJ, van der Bruggen P, (2006) Human T cell responses against melanoma. Annu Rev Immunol 24: 175-208.
11. De Smet C, Loriot A, (2013) DNA hypomethylation and activation of germline-specific genes in cancer. Adv Exp Med Biol 754: 149-166.
12. Kouzarides T, (2007) Chromatin modifications and their function. Cell 128: 693-705.
13. Cedar H, Bergman Y, (2009) Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 10: 295-304.
14. Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, et al. (2003) Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol 13: 1192-1200.
15. Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439: 871-874.
16. Selker EU, (1998) Trichostatin A causes selective loss of DNA methylation in Neurospora. Proc Natl Acad Sci U S A 95: 9430-9435.
17. Weber M, Hellmann I, Stadler MB, Ramos L, Paabo S, et al. (2007) Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 39: 457-466.
18. Link PA, Gangisetty O, James SR, Woloszynska-Read A, Tachibana M, et al. (2009) Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. Mol Cancer Res 7: 851-862.
19. Rao M, Chinnasamy N, Hong JA, Zhang Y, Zhang M, et al. (2011) Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. Cancer Res 71: 4192-4204.
20. D'Alessio AC, Weaver IC, Szyf M, (2007) Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. Mol Cell Biol 27: 7462-7474.
21. Weiser TS, Guo ZS, Ohnmacht GA, Parkhurst ML, Tong-On P, et al. (2001) Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1. J Immunother 24: 151-161.
22. Wischnewski F, Pantel K, Schwarzenbach H, (2006) Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1,-A2,-A3, and-A12 in human cancer cells. Mol Cancer Res 4: 339-349.
23. De Smet C, Loriot A, Boon T, (2004) Promoter-dependent mechanism leading to selective hypomethylation within the 5' region of gene MAGE-A1 in tumor cells. Mol Cell Biol 24: 4781-4790.
24. Loriot A, De Plaen E, Boon T, De Smet C, (2006) Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. J Biol Chem 281: 10118-10126.
25. Wu LP, Wang X, Li L, Zhao Y, Lu S, et al. (2008) Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol 28: 3219-3235.
26. Campbell MJ, Turner BM, (2013) Altered histone modifications in cancer. Adv Exp Med Biol 754: 81-107.
27. Steele N, Finn P, Brown R, Plumb JA, (2009) Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br J Cancer 100: 758-763.
28. Wischnewski F, Friese O, Pantel K, Schwarzenbach H, (2007) Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. Mol Cancer Res 5: 749-759.
29. Mutskov V, Felsenfeld G, (2004) Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. Embo J 23: 138-149.
30. Jin B, Li Y, Robertson KD, (2011) DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer 2: 607-617.
31. Feldman N, Gerson A, Fang J, Li E, Zhang Y, et al. (2006) G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol 8: 188-194.
32. Fouse SD, Shen Y, Pellegrini M, Cole S, Meissner A, et al. (2008) Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2: 160-169.
33. Walsh CP, Bestor TH, (1999) Cytosine methylation and mammalian development. Genes Dev 13: 26-34.
34. Akers SN, Odunsi K, Karpf AR, (2010) Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy. Future Oncol 6: 717-732.
35. Anichini A, Mortarini R, Vegetti C, Molla A, Borri A,et al. (1999) Melanoma: The Milan Melanoma Cell Lines. In: Masters JRW, Palsson B, editors. Human Cell Culture: Kluwer Academic Publishers. pp. 283-292.
36. Brasseur F (1999) Melanoma: Brussels Melanoma Cell Lines. In: Masters JRW, Palsson B, editors. Human Cell Culture: Kluwer Academic Publishers. pp. 275-282.
37. Tilman G, Loriot A, Van Beneden A, Arnoult N, Londono-Vallejo JA, et al. (2009) Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells. Oncogene 28: 1682-1693.
38. Kholmanskikh O, Loriot A, Brasseur F, De Plaen E, De Smet C, (2008) Expression of BORIS in melanoma: lack of association with MAGE-A1 activation. Int J Cancer 122: 777-784.
39. Loriot A, Parvizi GK, Reister S, De Smet C, (2012) Silencing of cancer-germline genes in human preimplantation embryos: evidence for active de novo DNA methylation in stem cells. Biochem Biophys Res Commun 417: 187-191.