Lipidomics identification of metabolic biomarkers in chemically induced hypertriglyceridemic mice

Journal of Proteome Research

Volumn 12, Issue 3, 2013, Pages 1387-1398

  Kwan, Hiu Yee ^a   Hu, Yong Mei ^a   Chan, Chi Leung ^a   Cao, Hui Hui ^a   Cheng, Chi Yan ^a   Pan, Si Yuan ^b   Tse, Kai Wing ^a   Wu, Yiu Cheong ^a   Yu, Zhi Ling ^a   Fong, Wang Fun ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

high resolution MS MS fragmentation; malonyl CoA; quantification; reversed phase liquid chromatography (RPLC)

Indexed keywords

ACETYL COENZYME A; ARACHIDONIC ACID; BIOLOGICAL MARKER; DIGLYCEROID; DOCOSAHEXAENOIC ACID; FATTY ACID; GLYCEROL; ISOTOPE; LINOLEIC ACID; MALONYL COENZYME A; OLEIC ACID; PALMITIC ACID; PHOSPHOLIPID; SCHIZANDRIN B; STEARIC ACID; SUCCINYL COENZYME A; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; FATTY ACID BLOOD LEVEL; GLYCEROL BLOOD LEVEL; HISTOPATHOLOGY; HYPERTRIGLYCERIDEMIA; ISOTOPE LABELING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIPID DIET; LIPID METABOLISM; LIPIDOMICS; LIQUID CHROMATOGRAPHY; LIVER; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SERUM; TANDEM MASS SPECTROMETRY; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84874633943     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3010327     Document Type: Article

References (28)

1. Pejic, R. N; Lee, D. T. Hypertriglyceridemia J. Am. Board Fam. Med. 2006, 19, 310-316
2. Frederoclspm, D. S.; Lees, R. S. A system for phenotyping hyperlipoproteinemia Circulation 1965, 32, 321-327
3. Tilg, H.; Kaser, A. Treatment strategies in nonalcoholic fatty liver disease Nat. Clin. Pract. Gastroenterol. Hepatol. 2005, 2, 148-155
4. Khurram, M.; Ashraf, M. M. A clinical and biochemical profile of biopsy-proven non-alcoholic Fatty liver disease subjects J. Coll. Physicans Surg. Pak. 2007, 17, 531-534
5. Tarantino, G.; Colao, A.; Capone, D.; Conca, P.; Tarantino, M.; Grimaldi, E.; Chianese, D.; Finelli, C.; Contaldo, F.; Scopacasa, F.; Savastano, S. Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease J. Biol. Regul. Homeostatic Agents 2011, 25, 47-55
6. Hegele, R. A.; Pollex, R. L. Hypertriglyceridemia: phenomics and genomics Mol. Cell. Biochem. 2009, 326, 35-43
7. Pirih, F.; Lu, J. X.; Ye, F.; Bezouglaia, O.; Atti, E.; Ascenzi, M. G.; Tetradis, S.; Demer, L.; Aghaloo, T.; Tintut, Y. Adverse effects of hyperlipidemia on bone regeneration and strength J. Bone Miner. Res. 2012, 27, 309-318
8. Krugner-Higby, L.; Shelness, G. S.; Holler, A. Heritable, diet-induced hyperlipidemia in California mice (Peromyscus californicus) is due to increased hepatic secretion of very low density lipoprotein triacylglycerol Compens. Med. 2006, 56, 468-475
9. Park, S. H.; Ko, S. K.; Choi, J. G.; Chung, S. H. Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice Arch. Pharm. Res. 2006, 29, 256-264
10. Moon, Y. A.; Liang, G.; Xie, X.; Frank-Kamenetsky, M.; Fitzgerald, K.; Koteliansky, V.; Brown, M. S.; Goldstein, J. L.; Horton, J. D. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals Cell Metab. 2012, 15, 240-246
11. Taleb-Dida, N.; Krouf, D.; Bouchenak, M. Globularia alypum aqueous extract decreases hypertriglyceridemia and ameliorates oxidative status of the muscle, kidney, and heart in rats fed a high-fructose diet Nutr. Res. (N.Y.) 2011, 31, 488-495
12. Hartvigsen, K.; Binder, C. J.; Hansen, L. F.; Rafia, A.; Juliano, J.; Hörkkö, S.; Steinberg, D.; Palinski, W.; Witztum, J. L.; Li, A. C. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome Arterioscler., Thromb., Vasc. Biol. 2007, 27, 878-885
13. Weinstock, P. H.; Bisgaier, C. L.; Aalto-Setälä, K.; Radner, H.; Ramakrishnan, R.; Levak-Frank, S.; Essenburg, A. D.; Zechner, R.; Breslow, J. L. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes J. Clin. Invest. 1995, 96, 2555-2568
14. Hofker, M. H.; van Vlijmen, B. J. M.; Havekes, L. M. Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis Atherosclerosis 1998, 137, 1-11
15. Pan, S. Y.; Dong, H.; Zhao, X. Y.; Xiang, C. J.; Fang, H. Y.; Fong, W. F.; Yu, Z. L.; Ko, K. M. Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic miceet al J. Pharm. Pharmacol. 2008, 60, 399-403
16. Pan, S. Y.; Dong, H.; Han, Y. F.; Li, W. Y.; Zhao, X. Y.; Ko, K. M. A novel experimental model of acute hypertriglyceridemia induced by Schisandrin B Eur. J. Pharmacol. 2006, 537, 200-204
17. Pan, S. Y.; Dong, H.; Guo, B. F.; Zhang, Y.; Yu, Z. L.; Fong, W. F.; Han, Y. F.; Ko, K. M. Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate Naunyn-Schmiedeberg's Arch. Pharmacol. 2011, 383, 585-591
18. Dennis, E. A. Lipidomics joins the omics evolution Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 2089-2090
19. Meikle, P. J.; Christopher, M. J. Lipidomics is providing new insight into the metabolic syndrome and its sequelae Curr. Opin. Lipidol. 2011, 22, 210-215
20. Sommer, U.; Herscovitz, H.; Welty, F. K.; Costello, C. E. LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures J. Lipid Res. 2007, 47, 804-814
21. Chan, P. T.; Fong, W. P.; Cheung, Y. L.; Huang, Y.; Ho, W. K.; Chen, Z. Y. Jasmine green tea epicatechins are hypolipidemic in hamsters (Mesocricetus auratus) fed a high fat diet J. Nutr. 1999, 129, 1094-1101
22. Mojgan, M.; Nicolaou, A. Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry Rapid Commun. Mass Spectrom. 2006, 20, 3023-3029
23. Ko, R. K. M.; Mak, D. H. F. Schisandrin B and other dibenzocyclooctadiene lignans. In Modern Herbal Medicine: Modern Basis in Health and Disease Management; Packer, L.; Halliwell, B.; Ong, C. N., Eds.; Marcel Dekker: New York, 2004; pp 289-314.
24. Prip-Buus, C.; Pegorier, J. P.; Duee, P. H.; Kohl, C.; Girard, J. Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes Biochem. J. 1990, 269, 409-415
25. Rasmussen, B. B.; Holmback, U. C.; Volpi, E.; Morio-Liondore, B.; Paddon-Jones, D.; Wolfe, R. R. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle J. Clin. Invest. 2002, 110, 1687-1693
26. Folmes, C. D. L.; Lopaschuk, G. D. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity Cardiovasc. Res. 2007, 73, 278-287
27. Pizer, E. S.; Thupari, J.; Han, W. F.; Pinn, M. L.; Chrest, F. J.; Frehywot, G. L.; Townsend, C. A.; Kuhajda, F. P. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Res. 2000, 60, 213-218
28. Masson, D.; Staels, B.; Gautier, T.; Desrumaux, C.; Athias, A.; Le Guern, N.; Schneider, M.; Zak, Z.; Dumont, L.; Deckert, V.; Tall, A.; Jiang, X. C.; Lagrost, L. Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse J. Lipid Res. 2001, 45, 543-550