Increasing Transfers-Out from an Antiretroviral Treatment Service in South Africa: Patient Characteristics and Rates of Virological Non-Suppression

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Nglazi, Mweete D ^a,b   Kaplan, Richard ^a   Orrell, Catherine ^a   Myer, Landon ^c   Wood, Robin ^a   Bekker, Linda Gail ^a   Lawn, Stephen D ^a,d  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b INTERNATIONAL UNION AGAINST TUBERCULOSIS AND LUNG DISEASE   (France)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ADOLESCENT; ARTICLE; COHORT ANALYSIS; FOLLOW UP; HEALTH SERVICE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK FACTOR; SOUTH AFRICA; SURVIVAL; VIROLOGY; VIRUS LOAD; ADULT; CD4 LYMPHOCYTE COUNT; COMMUNITY CARE; FEMALE; HIV INFECTIONS; INFECTION CONTROL; MALE; MEDICATION COMPLIANCE; ORGANIZATION AND MANAGEMENT; OUTPATIENT DEPARTMENT; PROBABILITY; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; AMBULATORY CARE FACILITIES; ANTI-RETROVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; COMMUNICABLE DISEASE CONTROL; COMMUNITY HEALTH SERVICES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; OUTCOME ASSESSMENT (HEALTH CARE); PROBABILITY; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SOUTH AFRICA; VIRAL LOAD; YOUNG ADULT;

EID: 84874612857     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057907     Document Type: Article

References (23)

1. World Health Organization (2011) Global HIV/AIDS response: Epidemic update and health sector progress towards universal access. Progress report 2011. World Health Organization, Geneva. Available: http://whqlibdoc.who.int/publications/2011/9789241502986_eng.pdf. Accessed 2012 Mar 8.
2. Cornell M, Grimsrud A, Fairall L, Fox MP, van Cutsem G, et al. (2010) Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007. Aids 24: 2263-2270.
3. Rosen S, Fox MP, Gill CJ, (2007) Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med 4: e298.
4. Lawn SD, Harries AD, Anglaret X, Myer L, Wood R, (2008) Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. Aids 22: 1897-1908.
5. Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, et al. (2006) Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet 367: 817-824.
6. Brinkhof MWG, Dabis F, Myer L, Bangsberg DR, Boulle A, et al. (2008) Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bull World Health Organ 86: 559-567.
7. Nglazi MD, Lawn SD, Kaplan R, Kranzer K, Orrell C, et al. (2011) Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South Africa. J Acquir Immune Defic Syndr 56: e1-8.
8. Yu JK, Tok TS, Tsai JJ, Chang WS, Dzimadzi RK, et al. (2008) What happens to patients on antiretroviral therapy who transfer out to another facility? PLoS One 3: e2065.
9. Wester CW, Kim S, Bussmann H, Avalos A, Ndwapi N, et al. (2005) Initial response to highly active antiretroviral therapy in HIV-1C-infected adults in a public sector treatment program in Botswana. J Acquir Immune Defic Syndr 40: 336.
10. Lawn SD, Myer L, Orrell C, Bekker LG, Wood R, (2005) Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design. Aids 19: 2141.
11. Lawn SD, Myer L, Bekker LG, Wood R, (2006) Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control. Aids 20: 1605.
12. Statistics South Africa (2011) Census 2011 Community Profiles Database. Statistics South Africa, Pretoria. Available: http://www.lib.uct.ac.za/governmentpublications/govpub-news/census-2011-community-profiles-database/. Accessed 2012 Dec 27.
13. Boulle A, Bock P, Osler M, Cohen K, Channing L, et al. (2008) Antiretroviral therapy and early mortality in South Africa. Bull World Health Organ 86: 678-687.
14. National Department of Health (1997) White Paper for the Transformation of the Health System in South Africa. National Department of Health, Pretoria.
15. Mulamba D, Fullem A, Hirschhorn I, Allers C, Oser R, et al. (2010) Decentralizing Antiretroviral Treatment Services at Primary Health Care Facilities:A Guide to Expanding Access and Care in Resource-Limited, Generalized HIV Epidemic Settings. Arlington,Va.: USAID {pipe} aiDSTar-One Project,Task Order 1.
16. Mukora R, Charalambous S, Dahab M, Hamilton R, Karstaedt A, (2011) A study of patient attitudes towards decentralisation of HIV care in an urban clinic in South Africa. BMC Health Serv Res 11: 205.
17. Lawn SD, Fraenzel A, Kranzer K, Caldwell J, Bekker LG, et al. (2011) Provider-initiated HIV testing increases access of patients with HIV-associated tuberculosis to antiretroviral treatment. S Afr Med J 101: 258-262.
18. National Department of Health (2010) HCT Policy Guidelines March 2010. National Department of Health, Pretoria.
19. National Department of Health (2010) National Antiretroviral Treatment Guidelines. National Department of Health, Pretoria.
20. d'Arminio Monforte A, Lepri AC, Rezza G, Pezzotti P, Antinori A, et al. (2000) Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naive patients. I.CO.N.A. Study Group. Italian Cohort of Antiretroviral-Naive Patients. Aids 14: 499-507.
21. Mocroft A, Youle M, Moore A, Sabin CA, Madge S, et al. (2001) Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre. Aids 15: 185.
22. Paredes R, Lalama CM, Ribaudo HJ, Schackman BR, Shikuma C, et al. (2010) Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure. Journal of Infectious Diseases 201: 662-671.
23. Department of Health and Human Sevices Panel on Antiretroviral Guidelines for Adults and Adolescents (2011) Australian commentary on DHHS guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Available: http://ashm.org.au/projects/arvguidelines/Default.asp?publicationID=4&SectionID=439. Accessed 2012 Apr 3.