Carbohydrate-mediated polyethylene glycol conjugation of TSH improves its pharmacological properties

Endocrinology

Volumn 154, Issue 3, 2013, Pages 1373-1383

  Park, Anna ^a   Honey, Denise M ^a   Hou, Lihui ^a   Bird, Julie J ^a   Zarazinski, Christine ^a   Searles, Michelle ^a   Braithwaite, Christian ^a   Kingsbury, Jonathan S ^a   Kyazike, Josephine ^a   Culm Merdek, Kerry ^a   Greene, Ben ^a   Stefano, James E ^a   Qiu, Huawei ^a   McPherson, John M ^a   Pan, Clark Q ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSE; MACROGOL; RADIOACTIVE IODINE; RECOMBINANT THYROTROPIN; SIALIC ACID; THYROGLOBULIN; THYROTROPIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; GLOMERULUS FILTRATION; GLYCOSYLATION; MALE; MOUSE; NONHUMAN; PLASMA HALF LIFE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; THYROID CANCER; THYROTROPIN BLOOD LEVEL;

ANIMALS; CARBOHYDRATES; FEMALE; GLYCOSYLATION; HALF-LIFE; HUMANS; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, THYROTROPIN; RECOMBINANT PROTEINS; SIALIC ACIDS; THYROTROPIN;

EID: 84874601289     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2010     Document Type: Article

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