메뉴 건너뛰기




Volumn 29, Issue 10, 2012, Pages 783-791

Pharmacological and clinical profile of recently approved second-generation antipsychotics: Implications for treatment of schizophrenia in older patients

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; ASENAPINE; BENZODIAZEPINE; CHLORPROMAZINE; CLOZAPINE; CREATININE; HALOPERIDOL; ILOPERIDONE; LURASIDONE; OLANZAPINE; OROSOMUCOID; PALIPERIDONE; PLACEBO; PROLACTIN; QUETIAPINE; RISPERIDONE;

EID: 84874582243     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-012-0009-0     Document Type: Review
Times cited : (16)

References (81)
  • 1
    • 84863675668 scopus 로고    scopus 로고
    • Schizophrenia
    • R.E. Rakel E.T. Bope (eds) Saunders Elsevier Philadelphia
    • Rado J, Janicak PG. Schizophrenia. In: Rakel RE, Bope ET, editors. Conn's current therapy 2009. Philadelphia: Saunders Elsevier; 2009.
    • (2009) Conn's Current Therapy 2009
    • Rado, J.1    Janicak, P.G.2
  • 2
    • 0029832034 scopus 로고    scopus 로고
    • The prevalence of psychiatric disorders in elderly residents of public housing
    • 8914505 10.1093/gerona/51A.6.M319 1:STN:280:DyaK2s%2FntFKmuw%3D%3D
    • Rabins PV, Black B, German P, et al. The prevalence of psychiatric disorders in elderly residents of public housing. J Gerontol A Biol Sci Med Sci. 1996;51(6):M319-24.
    • (1996) J Gerontol A Biol Sci Med Sci , vol.51 , Issue.6
    • Rabins, P.V.1    Black, B.2    German, P.3
  • 3
    • 48849104809 scopus 로고    scopus 로고
    • Clinical characterization of late- and very late-onset first psychotic episode in psychiatric inpatients
    • 10.1097/JGP.0b013e31816c7b3c
    • Girard C, Simard M. Clinical characterization of late- and very late-onset first psychotic episode in psychiatric inpatients. Am J Geriatr Psychiatr. 2008;16:478-87.
    • (2008) Am J Geriatr Psychiatr , vol.16 , pp. 478-487
    • Girard, C.1    Simard, M.2
  • 4
    • 0029144446 scopus 로고
    • Studies of the outcome of schizophrenia in later life
    • 7583495 1:STN:280:DyaK28%2FltlWmtw%3D%3D
    • Cohen CI. Studies of the outcome of schizophrenia in later life. Psychiatr Serv. 1995;46:877-9.
    • (1995) Psychiatr Serv , vol.46 , pp. 877-879
    • Cohen, C.I.1
  • 5
    • 0030755611 scopus 로고    scopus 로고
    • Functional impairments in elderly patients with schizophrenia and major affective illness in the community: Social skills, living skills, and behavior problems
    • DOI 10.1016/S0005-7894(97)80033-0
    • Bartels SJ, Muser KT, Miles KM. Functional impairments in elderly patients with schizophrenia and major affective disorders living in the community: social skills, living skills and behaviour problems. Behav Ther. 1997;28:43-63. (Pubitemid 27319034)
    • (1997) Behavior Therapy , vol.28 , Issue.1 , pp. 43-63
    • Bartels, S.J.1    Mueser, K.T.2    Miles, K.M.3
  • 8
    • 34548086834 scopus 로고    scopus 로고
    • Comparison of older patients with bipolar disorder and schizophrenia/schizoaffective disorders
    • 10.1097/JGP.0b013e318065b06b
    • Gupta S, Steinmeyer CH, Lockwood K, et al. Comparison of older patients with bipolar disorder and schizophrenia/schizoaffective disorders. Am J Geriatr Psychiatr. 2007;15:627-33.
    • (2007) Am J Geriatr Psychiatr , vol.15 , pp. 627-633
    • Gupta, S.1    Steinmeyer, C.H.2    Lockwood, K.3
  • 9
    • 57549112956 scopus 로고    scopus 로고
    • The needs of older adults with schizophrenia: Implication for psychological interventions
    • 18973972 10.1016/j.cpr.2008.09.010
    • Berry K, Barrowclough C. The needs of older adults with schizophrenia: implication for psychological interventions. Clin Psychol Rev. 2009;29:68-76.
    • (2009) Clin Psychol Rev , vol.29 , pp. 68-76
    • Berry, K.1    Barrowclough, C.2
  • 10
    • 0027413068 scopus 로고
    • Age-related correlations in patient symptom management strategies in schizophrenia: An exploratory study
    • Cohen CI. Age-related correlations in patient symptom management strategies in schizophrenia: an exploratory study. Int J Geriatr Psychiatr. 1993;8:211-3. (Pubitemid 23122993)
    • (1993) International Journal of Geriatric Psychiatry , vol.8 , Issue.3 , pp. 211-213
    • Cohen, C.I.1
  • 12
    • 0033960480 scopus 로고    scopus 로고
    • Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: An international consensus
    • DOI 10.1176/appi.ajp.157.2.172
    • Howard R, Rabins PV, Seeman MV, Jeste DV, The International Late-Onset Schizophrenia Group. Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. Am J Psychiatr. 2000;157(2):172-8. (Pubitemid 30080894)
    • (2000) American Journal of Psychiatry , vol.157 , Issue.2 , pp. 172-178
    • Howard, R.1    Rabins, P.V.2    Seeman, M.V.3    Jeste, D.V.4
  • 14
    • 13444271819 scopus 로고    scopus 로고
    • Neurocognitive impairment across the lifespan in schizophrenia: An update
    • DOI 10.1016/j.schres.2004.07.005
    • Kurtz MM. Neurocognitive impairment across the lifespan in schizophrenia: an update. Schizophr Res. 2005;74:15-26. (Pubitemid 40203180)
    • (2005) Schizophrenia Research , vol.74 , Issue.1 , pp. 15-26
    • Kurtz, M.M.1
  • 19
    • 24644504074 scopus 로고    scopus 로고
    • Anxiety: Comorbidity and impact in severe mental illness
    • Meeks S, Woodruff-Borden J. Anxiety: comorbidity and impact in severe mental illness. J Clin Geropsychol. 1996;2:141-52.
    • (1996) J Clin Geropsychol , vol.2 , pp. 141-152
    • Meeks, S.1    Woodruff-Borden, J.2
  • 20
    • 2542509446 scopus 로고    scopus 로고
    • Mortality and causes of death in schizophrenia in Stockholm County, Sweden
    • 10978869 10.1016/S0920-9964(99)00191-7 1:STN:280:DC%2BD3cvpt1Wquw%3D%3D
    • Osby U, Correia N, Brandt L, et al. Mortality and causes of death in schizophrenia in Stockholm County, Sweden. Schizophr Res. 2000;45:21-8.
    • (2000) Schizophr Res , vol.45 , pp. 21-28
    • Osby, U.1    Correia, N.2    Brandt, L.3
  • 23
    • 0242490992 scopus 로고    scopus 로고
    • International Multisite Double-Blind Trial of the Atypical Antipsychotics Risperidone and Olanzapine in 175 Elderly Patients with Chronic Schizophrenia
    • DOI 10.1176/appi.ajgp.11.6.638
    • Jeste DV, Barak Y, Madhusoodanan S, Grossman F, Gharabawi G. International multisite double-blind trial of the atypical antipsychotics risperidone and olanzapine in 175 elderly patients with chronic schizophrenia. Am J Geriatr Psychiatr. 2003;11:638-47. (Pubitemid 37392328)
    • (2003) American Journal of Geriatric Psychiatry , vol.11 , Issue.6 , pp. 638-647
    • Jeste, D.V.1    Barak, Y.2    Madhusoodanan, S.3    Grossman, F.4    Gharabawi, G.5
  • 24
    • 36448940117 scopus 로고    scopus 로고
    • Quetiapine for elderly non-responsive schizophrenia patients
    • DOI 10.1016/j.psychres.2007.06.015, PII S0165178107001977
    • Mazeh D, Paleacu D, Barak Y. Quetiapine for elderly non-responsive schizophrenia patients. Psychiatr Res. 2008;157:265-7. (Pubitemid 350166561)
    • (2008) Psychiatry Research , vol.157 , Issue.1-3 , pp. 265-267
    • Mazeh, D.1    Paleacu, D.2    Barak, Y.3
  • 25
    • 33750614310 scopus 로고    scopus 로고
    • Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: A 52-week, open-label comparison with olanzapine
    • DOI 10.1007/s00213-006-0564-3
    • Wlodzimiewrz CK, Marcus RN, Tobeyns A, Nyilas M, McQuade RD. Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label comparison with olanzapine. Psychopharmacology. 2006;189:259-66. (Pubitemid 44691547)
    • (2006) Psychopharmacology , vol.189 , Issue.2 , pp. 259-266
    • Chrzanowski, W.K.1    Marcus, R.N.2    Torbeyns, A.3    Nyilas, M.4    McQuade, R.D.5
  • 26
    • 58149107588 scopus 로고    scopus 로고
    • A randomized, open-label comparison of 2 switching strategies to aripiprazole treatment in patients with schizophrenia
    • 18794650 10.1097/JCP.0b013e3181842586 1:CAS:528:DC%2BD1cXhtFart7fN
    • Takeuchi H, Suzuki T, Uchida H, et al. A randomized, open-label comparison of 2 switching strategies to aripiprazole treatment in patients with schizophrenia. J Clin Psychopharmacol. 2008;28:540-3.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 540-543
    • Takeuchi, H.1    Suzuki, T.2    Uchida, H.3
  • 27
    • 10044223558 scopus 로고    scopus 로고
    • Clinical experience with aripiprazole treatment in ten elderly patients with schizophrenia or schizoaffective disorder: Retrospective case studies
    • Madhusoodan S, Brenner R, Gupta S, Reddy H, Bogunovic O. Clinical experience with aripiprazole treatment in ten elderly patients with schizophrenia or schizoaffective disorder: retrospective case studies. CNS Spectr. 2004;9(11):862-7. (Pubitemid 39602941)
    • (2004) CNS Spectrums , vol.9 , Issue.11 , pp. 862-867
    • Madhusoodanan, S.1    Brenner, R.2    Gupta, S.3    Reddy, H.4    Bogunovic, O.5
  • 28
    • 33750350329 scopus 로고    scopus 로고
    • Aripiprazole use in individuals with intellectual disability and psychotic or behavioural disorders: A case series
    • DOI 10.1177/0269881106067765
    • Shastri M, Alla L, Sabaratnam M. Aripiprazole use in individuals with intellectual disability and psychotic or behavioural disorders: a case series. J Psychopharmacol. 2006;20(6):863-7. (Pubitemid 44622753)
    • (2006) Journal of Psychopharmacology , vol.20 , Issue.6 , pp. 863-867
    • Shashtri, M.1    Alla, L.2    Sabaratnam, M.3
  • 29
    • 34147160318 scopus 로고    scopus 로고
    • Aripiprazole worsening positive symptoms and meantime reducing negative symptoms in a patient with paranoid schizophrenia
    • Ponde MP, Novaes CM. Aripiprazole worsening positive symptoms and meantime reducing negative symptoms in a patient with paranoid schizophrenia. Rev Bras Psiquiatr. 2007;28(1):86-95.
    • (2007) Rev Bras Psiquiatr , vol.28 , Issue.1 , pp. 86-95
    • Ponde, M.P.1    Novaes, C.M.2
  • 30
    • 33749404955 scopus 로고    scopus 로고
    • Medical comorbidity in women and men with schizophrenia: A population-based controlled study
    • DOI 10.1111/j.1525-1497.2006.00563.x
    • Carney C, Jones L, Woolson RF. Medical comorbidity in women and men with schizophrenia. J Gen Intern Med. 2006;21:1133-7. (Pubitemid 44506864)
    • (2006) Journal of General Internal Medicine , vol.21 , Issue.11 , pp. 1133-1137
    • Carney, C.P.1    Jones, L.2    Woolson, R.F.3
  • 32
    • 39749099978 scopus 로고    scopus 로고
    • Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: A double-blind, placebo-controlled study with long-term open-label extension
    • 10.1097/JGP.0b013e31815a3e7a
    • Tzimos A, Samokhvalov V, Kramer M, et al. Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: a double-blind, placebo-controlled study with long-term open-label extension. Am J Geriatr Psychiatr. 2008;16(1):31-43.
    • (2008) Am J Geriatr Psychiatr , vol.16 , Issue.1 , pp. 31-43
    • Tzimos, A.1    Samokhvalov, V.2    Kramer, M.3
  • 34
    • 33750517755 scopus 로고    scopus 로고
    • Clinical spectrum of the osmotic-controlled release oral delivery system (OROS*), an advanced oral delivery form
    • DOI 10.1185/030079906X132613
    • ®), and advanced oral delivery form. Curr Med Res Opin. 2005;22:1879-92. (Pubitemid 44663390)
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.10 , pp. 1879-1892
    • Conley, R.1    Gupta, S.K.2    Sathyan, G.3
  • 35
    • 0028096538 scopus 로고
    • Risperidone: A review of its pharmacology and therapeutic potential in the treatment of schizophrenia
    • 10.2165/00003495-199448020-00009
    • Gram S, Fitlon A. Risperidone: a review of its pharmacology and therapeutic potential in the treatment of schizophrenia. Drugs. 1994;48(2):253-73.
    • (1994) Drugs , vol.48 , Issue.2 , pp. 253-273
    • Gram, S.1    Fitlon, A.2
  • 36
  • 37
    • 33745461470 scopus 로고    scopus 로고
    • Pharmacokinetics and dopamine D(2) and serotonin 5-HT(2A) receptor occupancy of paliperidone in healthy subjects [abstract no. P.1.053]
    • Plus poster presented at the 18th European College of Neuropsychopharmacology Congress; 2005 Oct 22-26; Amsterdam
    • Karlsson P, Dencker E, Nyberg S, et al. Pharmacokinetics and dopamine D(2) and serotonin 5-HT(2A) receptor occupancy of paliperidone in healthy subjects [abstract no. P.1.053]. Eyr Neuropsychopharmacol. 2005;15(Suppl. 3):386. Plus poster presented at the 18th European College of Neuropsychopharmacology Congress; 2005 Oct 22-26; Amsterdam.
    • (2005) Eyr Neuropsychopharmacol , vol.15 , Issue.SUPPL. 3 , pp. 386
    • Karlsson, P.1    Dencker, E.2    Nyberg, S.3
  • 38
    • 0028237637 scopus 로고
    • Risperidone: A novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity
    • Leysen JE, Janssen PM, Megens AA, Schotte A. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatr. 1994;55(Suppl. 5):5-12. (Pubitemid 24179363)
    • (1994) Journal of Clinical Psychiatry , vol.55 , Issue.5 SUPPL. , pp. 5-12
    • Leysen, J.E.1    Janssen, P.M.F.2    Megens, A.A.H.P.3    Schotte, A.4
  • 39
    • 34247868503 scopus 로고    scopus 로고
    • A pharmacokinetic model to document the interconversion between paliperidone's enantiomers [abstract no. PII-72]
    • 10.1016/j.clpt.2005.12.197
    • Cleton A, Rossenu S, Vermeulen A, et al. A pharmacokinetic model to document the interconversion between paliperidone's enantiomers [abstract no. PII-72]. Clin Pharmacol Ther. 2006;79(2):55.
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.2 , pp. 55
    • Cleton, A.1    Rossenu, S.2    Vermeulen, A.3
  • 40
    • 34247880459 scopus 로고    scopus 로고
    • Paliperidone extended release
    • DOI 10.2165/00023210-200721050-00005
    • Yang LPH, Plosker GL. Paliperidone extended release. CNS Drugs. 2007;21(5):1172-7047. (Pubitemid 46698504)
    • (2007) CNS Drugs , vol.21 , Issue.5 , pp. 417-425
    • Yang, L.P.H.1    Plosker, G.L.2
  • 41
    • 38349070118 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetics of an extended-release formulation of paliperidone with an immediate-release formulation of risperidone
    • Rossenu S, Cleton A, Talluri K, et al. Evaluation of the pharmacokinetics of an extended-release formulation of paliperidone with an immediate-release formulation of risperidone. Clin Pharm Ther. 2007;81(Suppl. 1):S62.
    • (2007) Clin Pharm Ther , vol.81 , Issue.SUPPL. 1 , pp. 62
    • Rossenu, S.1    Cleton, A.2    Talluri, K.3
  • 42
    • 0028223820 scopus 로고
    • Plasma protein binding of risperidone and its distribution in blood
    • Mannens G, Meuldermans W, Snoeck E, Heykants J. Plasma protein binding of risperidone and its distribution in blood. Psychopharmacology. 1994;114:566-72. (Pubitemid 24152136)
    • (1994) Psychopharmacology , vol.114 , Issue.4 , pp. 566-572
    • Mannens, G.1    Meuldermans, W.2    Snoeck, E.3    Heykants, J.4
  • 43
    • 33846619202 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of a single oral dose of 14C-paliperidone 1 mg in healthy subjects
    • Vermeir M, Boom S, Naessens I, et al. Absorption, metabolism and excretion of a single oral dose of 14C-paliperidone 1 mg in healthy subjects. Eur Neuropsychopharmacol. 2005;30:S191-2.
    • (2005) Eur Neuropsychopharmacol , vol.30
    • Vermeir, M.1    Boom, S.2    Naessens, I.3
  • 44
    • 72849121553 scopus 로고    scopus 로고
    • No pharmacokinetic interaction between paliperidone extended-release tablets and trimethoprim in healthy subjects
    • 19693799 10.1002/hup.1049 1:CAS:528:DC%2BD1MXhtl2kurbO
    • Thyssen A, Cleton A, Talluri K, Leempoels J, Janssens L, Boom S, Eerdekens M. No pharmacokinetic interaction between paliperidone extended-release tablets and trimethoprim in healthy subjects. Hum Psychopharmacol. 2009;24(7):532-9.
    • (2009) Hum Psychopharmacol , vol.24 , Issue.7 , pp. 532-539
    • Thyssen, A.1    Cleton, A.2    Talluri, K.3    Leempoels, J.4    Janssens, L.5    Boom, S.6    Eerdekens, M.7
  • 45
    • 37849046729 scopus 로고    scopus 로고
    • Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: Pooled data from three 6-week placebo controlled studies
    • Meltzer H, Kramer M, Gassmann-Mayer C, et al. Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week placebo controlled studies. Int J Neuropsychopharmacol. 2006;9:S225.
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 225
    • Meltzer, H.1    Kramer, M.2    Gassmann-Mayer, C.3
  • 47
    • 78650805541 scopus 로고    scopus 로고
    • Evaluation of the effect of paliperidone extended release and quetiapine on corrected QT intervals: A randomized, double-blind, placebo-controlled study
    • 20881844 10.1097/YIC.0b013e3283400d58
    • Hough DW, Natarajan J, Vandebosh A, et al. Evaluation of the effect of paliperidone extended release and quetiapine on corrected QT intervals: a randomized, double-blind, placebo-controlled study. Int Clin Psychopharmacol. 2011;26(1):25-34.
    • (2011) Int Clin Psychopharmacol , vol.26 , Issue.1 , pp. 25-34
    • Hough, D.W.1    Natarajan, J.2    Vandebosh, A.3
  • 49
    • 70350706273 scopus 로고    scopus 로고
    • The influence of hepatic impairment on the pharmacokinetics of paliperidone
    • 19825324 1:CAS:528:DC%2BD1MXhsVWrur3K
    • Boom S, Thyssen A, Crauwels H, et al. The influence of hepatic impairment on the pharmacokinetics of paliperidone. Int J Clin Pharmacol Ther. 2009;47(10):606-16.
    • (2009) Int J Clin Pharmacol Ther , vol.47 , Issue.10 , pp. 606-616
    • Boom, S.1    Thyssen, A.2    Crauwels, H.3
  • 50
    • 38349047565 scopus 로고    scopus 로고
    • Effects of renal impairment on the pharmacokinetic profile of paliperidone extended-release tablets
    • Thyssen A, Cleton A, Osselae NV. Effects of renal impairment on the pharmacokinetic profile of paliperidone extended-release tablets. Clin Pharm Ther. 2007;81(Suppl. 1):S63.
    • (2007) Clin Pharm Ther , vol.81 , Issue.SUPPL. 1 , pp. 63
    • Thyssen, A.1    Cleton, A.2    Osselae, N.V.3
  • 51
    • 80053043482 scopus 로고    scopus 로고
    • Dosing and switching strategies for paliperidone palmitate: Based on population pharmacokinetic modeling and clinical trial data
    • 21936586 1:CAS:528:DC%2BC3MXhsVOjsLrM
    • Samtani MN, Gopal S, Gassmann-Mayer C, Alphs L, Palumbo JM. Dosing and switching strategies for paliperidone palmitate: based on population pharmacokinetic modeling and clinical trial data. CNS Drugs. 2011;25(10):829-45.
    • (2011) CNS Drugs , vol.25 , Issue.10 , pp. 829-845
    • Samtani, M.N.1    Gopal, S.2    Gassmann-Mayer, C.3    Alphs, L.4    Palumbo, J.M.5
  • 52
    • 74449085079 scopus 로고    scopus 로고
    • Initiation of dosing and deltoid intramuscular paliperidone palmitate in schizophrenia: Pharmacokinetic rationale based on modeling and simulation
    • Samtani M, Sliwa JK, Haskins JT, et al. Initiation of dosing and deltoid intramuscular paliperidone palmitate in schizophrenia: pharmacokinetic rationale based on modeling and simulation. J Pharm Pract. 2009;22:216-7.
    • (2009) J Pharm Pract , vol.22 , pp. 216-217
    • Samtani, M.1    Sliwa, J.K.2    Haskins, J.T.3
  • 53
    • 67749084103 scopus 로고    scopus 로고
    • Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia
    • 10.1016/j.pnpbp.2009.05.014 1:CAS:528:DC%2BD1MXoslSjsbg%3D
    • Hough D, Lindenmayer JP, Gopal S, et al. Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatr. 2009;33(6):1022-31.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatr , vol.33 , Issue.6 , pp. 1022-1031
    • Hough, D.1    Lindenmayer, J.P.2    Gopal, S.3
  • 54
    • 69849099693 scopus 로고    scopus 로고
    • Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia a novel once-monthly, long-acting formulation of an atypical antipsychotic
    • 19725593 10.2165/11316870-000000000-00000 1:CAS:528:DC%2BD1MXhtlGnsLbF
    • Samtani MN, Vermeulen A, Stuyckens K. Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia a novel once-monthly, long-acting formulation of an atypical antipsychotic. Clin Pharmacokinet. 2009;48(9):585-600.
    • (2009) Clin Pharmacokinet , vol.48 , Issue.9 , pp. 585-600
    • Samtani, M.N.1    Vermeulen, A.2    Stuyckens, K.3
  • 55
    • 78649368022 scopus 로고    scopus 로고
    • A novel treatment option for schizophrenia
    • Rado J, Janicak PG. A novel treatment option for schizophrenia. Psychopharm Rev. 2010;45(1):1-8.
    • (2010) Psychopharm Rev , vol.45 , Issue.1 , pp. 1-8
    • Rado, J.1    Janicak, P.G.2
  • 56
    • 40849089245 scopus 로고    scopus 로고
    • Efficacy of iloperidone in the treatment of schizophrenia: Initial phase 3 studies
    • DOI 10.1097/JCP.0b013e3181692787, PII 0000471420080400100002
    • Potkin SG, Litman RE, Torres R, et al. Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. J Clin Psychopharmacol. 2008;28:S4-11. (Pubitemid 351397671)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Potkin, S.G.1    Litman, R.E.2    Torres, R.3    Wolfgang, C.D.4
  • 57
    • 40849111788 scopus 로고    scopus 로고
    • Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia
    • DOI 10.1097/JCP.0b013e318169d4ce, PII 0000471420080400100004
    • Cutler AJ, Kalali AH, Weiden PJ, et al. Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. J Clin Psychopharmacol. 2008;28(2 Suppl. 1):S20-8. (Pubitemid 351397673)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Cutler, A.J.1    Kalali, A.H.2    Weiden, P.J.3    Hamilton, J.4    Wolfgang, C.D.5
  • 58
    • 40849102838 scopus 로고    scopus 로고
    • Safety profile of iloperidone: A pooled analysis of 6-week acute-phase pivotal trials
    • DOI 10.1097/JCP.0b013e3181694f5a, PII 0000471420080400100003
    • Weiden PJ, Cutler AJ, Polymeropoulos MH, et al. Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol. 2008;28(2 Suppl. 1):S12-9. (Pubitemid 351397672)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Weiden, P.J.1    Cutler, A.J.2    Polymeropoulos, M.H.3    Wolfgang, C.D.4
  • 59
    • 0037195552 scopus 로고    scopus 로고
    • 1A receptor agonism
    • DOI 10.1016/S0006-8993(02)03570-9, PII S0006899302035709
    • Ichikawa J, Li Z, Dai J, et al. Atypical antipsychotic drugs, quetiapine, iloperidone and melperidone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 2002;956:349-57. (Pubitemid 35351402)
    • (2002) Brain Research , vol.956 , Issue.2 , pp. 349-357
    • Ichikawa, J.1    Li, Z.2    Dai, J.3    Meltzer, H.Y.4
  • 60
    • 0035673012 scopus 로고    scopus 로고
    • Extended radioligand binding profile of iloperidone: A broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders
    • DOI 10.1016/S0893-133X(01)00285-8, PII S0893133X01002858
    • Kalkman HO, Subramanian N, Hoyer D. Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology. 2001;25:904-14. (Pubitemid 34031895)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.6 , pp. 904-914
    • Kalkman, H.O.1    Subramanian, N.2    Hoyer, D.3
  • 61
    • 0038682110 scopus 로고    scopus 로고
    • 1A receptors
    • DOI 10.1016/S0024-3205(03)00419-3
    • Kalkman HO, Feuerbach D, Lotscher E. Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors. Life Sci. 2003;73(9):1151-9. (Pubitemid 36724916)
    • (2003) Life Sciences , vol.73 , Issue.9 , pp. 1151-1159
    • Kalkman, H.O.1    Feuerbach, D.2    Lotscher, E.3    Schoeffter, P.4
  • 63
    • 0036199878 scopus 로고    scopus 로고
    • Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone
    • DOI 10.1016/S0278-5846(01)00307-4, PII S0278584601003074
    • Subramanian N, Kalkman HO. Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Prog Neuropsychopharmacol Biol Psychiatr. 2002;26:553-60. (Pubitemid 34252950)
    • (2002) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.26 , Issue.3 , pp. 553-560
    • Subramanian, N.1    Kalkman, H.O.2
  • 64
    • 67649216860 scopus 로고    scopus 로고
    • Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia
    • 10.4088/JCP.08m04391 1:CAS:528:DC%2BD1MXhsFentbnL
    • Volpi S, Potkin SG, Malhotra AK, et al. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. J Clin Psychiatr. 2009;70(6):801-9.
    • (2009) J Clin Psychiatr , vol.70 , Issue.6 , pp. 801-809
    • Volpi, S.1    Potkin, S.G.2    Malhotra, A.K.3
  • 65
    • 70350574270 scopus 로고    scopus 로고
    • Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment in schizophrenia
    • 10.1038/mp.2008.52 1:CAS:528:DC%2BD1MXhtlSgs7vK
    • Volpi S, Heaton C, Mack K, et al. Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment in schizophrenia. Mol Psychiatr. 2009;14(11):1024-31.
    • (2009) Mol Psychiatr , vol.14 , Issue.11 , pp. 1024-1031
    • Volpi, S.1    Heaton, C.2    Mack, K.3
  • 66
    • 84859892919 scopus 로고    scopus 로고
    • Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis
    • 10.1002/gps.2737
    • Dubovsky SL, Frobose C, Phiri P, et al. Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis. Int J Geriatr Psychiatr. 2012;27(5):472-82.
    • (2012) Int J Geriatr Psychiatr , vol.27 , Issue.5 , pp. 472-482
    • Dubovsky, S.L.1    Frobose, C.2    Phiri, P.3
  • 67
    • 77955705345 scopus 로고    scopus 로고
    • Effects of water intake and smoking on the absorption of sublingually administered asenapine [abstract no. PIII-57]
    • Hulskotte E, Spaans E, Timmer C. Effects of water intake and smoking on the absorption of sublingually administered asenapine [abstract no. PIII-57]. Clin Pharmacol Ther. 2009;85(Suppl. 1):S20-8.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.SUPPL. 1
    • Hulskotte, E.1    Spaans, E.2    Timmer, C.3
  • 68
    • 78649386171 scopus 로고    scopus 로고
    • Asenapine. A review of the data
    • Janicak PG, Rado JT. Asenapine. a review of the data. Psychopharm Rev. 2009;44(12):89-96.
    • (2009) Psychopharm Rev , vol.44 , Issue.12 , pp. 89-96
    • Janicak, P.G.1    Rado, J.T.2
  • 69
    • 77953885825 scopus 로고    scopus 로고
    • Long-term assessment of asenapine versus olanzapine in patients with schizophrenia or schizoaffective disorder
    • 10.1055/s-0030-1248313
    • Shoemaker J, Naber D, Vrijland P, Panagides J, Emsley R. Long-term assessment of asenapine versus olanzapine in patients with schizophrenia or schizoaffective disorder. Pharmacopsychiatry. 2010;43:138-46.
    • (2010) Pharmacopsychiatry , vol.43 , pp. 138-146
    • Shoemaker, J.1    Naber, D.2    Vrijland, P.3    Panagides, J.4    Emsley, R.5
  • 70
    • 70350424361 scopus 로고    scopus 로고
    • Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation
    • 19843656 10.1177/0091270009344855 1:CAS:528:DC%2BD1MXhsVGmsb%2FO
    • Chapel S, Hutmacher MM, Haig G, et al. Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation. J Clin Pharmacol. 2009;49:1297-308.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1297-1308
    • Chapel, S.1    Hutmacher, M.M.2    Haig, G.3
  • 71
    • 58649100010 scopus 로고    scopus 로고
    • Asenapine: A novel psychopharmacological agent with a unique human receptor signature
    • 18308814 10.1177/0269881107082944 1:CAS:528:DC%2BD1MXisVClu7Y%3D
    • Shahid M, Walker GB, Zorn SN, et al. Asenapine: a novel psychopharmacological agent with a unique human receptor signature. J Psychopharmacol. 2009;23(1):65-73.
    • (2009) J Psychopharmacol , vol.23 , Issue.1 , pp. 65-73
    • Shahid, M.1    Walker, G.B.2    Zorn, S.N.3
  • 72
    • 84874632919 scopus 로고    scopus 로고
    • ABILIFY® (aripiprazole) prescribing information Accessed 25 Oct 2011
    • ABILIFY® (aripiprazole) prescribing information. http://www.abilify. com/pdf/pi.aspx?tc=89340&utm-source=google&utm-medium= organic-search&utm-term=aripiprazole+prescribing+information&q= aripiprazole+prescribing+information&hl=en&source=hp&gs-sm= s&gs-upl=1375l1375l0l1828l1l1l0l0l0l0l0l0ll0l0&oq= aripiprazole+prescribing+information&aq=f&aqi=g1&aql=1. Accessed 25 Oct 2011.
  • 73
    • 79958259592 scopus 로고    scopus 로고
    • Asenapine pharmacokinetics in hepatic and renal impairment
    • 21651314 10.2165/11590490-000000000-00000 1:CAS:528:DC%2BC3MXhtVKjsrbL
    • Peeters P, Bockbrader H, Spaans E, et al. Asenapine pharmacokinetics in hepatic and renal impairment. Clin Pharmacokinet. 2011;50(7):471-81.
    • (2011) Clin Pharmacokinet , vol.50 , Issue.7 , pp. 471-481
    • Peeters, P.1    Bockbrader, H.2    Spaans, E.3
  • 74
    • 80052848959 scopus 로고    scopus 로고
    • Lurasidone: The most recent addition to our antipsychotic armentarium: A review of the data
    • Fayad SM, Tandon R. Lurasidone: the most recent addition to our antipsychotic armentarium: a review of the data. Psychopharm Rev. 2011;46(6):41-8.
    • (2011) Psychopharm Rev , vol.46 , Issue.6 , pp. 41-48
    • Fayad, S.M.1    Tandon, R.2
  • 75
    • 84874600057 scopus 로고    scopus 로고
    • Accessed 25 Oct 2011
    • Latuda prescribing information. http://www.latuda.com/aboutLatuda/taking- latuda.html. Accessed 25 Oct 2011.
    • Latuda Prescribing Information
  • 76
    • 73849100354 scopus 로고    scopus 로고
    • Lurasidone: A new drug in development for schizophrenia
    • 19780705 10.1517/13543780903286388 1:CAS:528:DC%2BD1MXhtlKrtrjL
    • Meyer JM, Loebel AD, Schweizer E. Lurasidone: a new drug in development for schizophrenia. Expert Opin Investig Drugs. 2009;18(11):1715-26.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.11 , pp. 1715-1726
    • Meyer, J.M.1    Loebel, A.D.2    Schweizer, E.3
  • 77
    • 67649222011 scopus 로고    scopus 로고
    • Lurasidone in the treatment of acute schizophrenia: A double-blind, placebo-controlled trial
    • 10.4088/JCP.08m04905 1:CAS:528:DC%2BD1MXhsFentbnF
    • Nakamura M, Ogasa M, Guarino J, et al. Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial. J Clin Psychiatr. 2009;70(6):829-36.
    • (2009) J Clin Psychiatr , vol.70 , Issue.6 , pp. 829-836
    • Nakamura, M.1    Ogasa, M.2    Guarino, J.3
  • 78
    • 79952316290 scopus 로고    scopus 로고
    • Performance and interview-based assessments of cognitive change in a randomized, double blind comparison of lurasidone vs. ziprasidone
    • 10.1016/j.schres.2011.01.004
    • Harvey PD, Ogasa M, Cucchiaro J, et al. Performance and interview-based assessments of cognitive change in a randomized, double blind comparison of lurasidone vs. ziprasidone. Schizophrenia Res. 2011;127:188-94.
    • (2011) Schizophrenia Res , vol.127 , pp. 188-194
    • Harvey, P.D.1    Ogasa, M.2    Cucchiaro, J.3
  • 79
    • 77953753014 scopus 로고    scopus 로고
    • Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxy-tryptamine 7 (5-HT7) and 5-HT1A receptor activity
    • 20404009 10.1124/jpet.110.167346 1:CAS:528:DC%2BC3cXos1KltLo%3D
    • Ishibashi T, Horisawa T, Tokuda K, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxy-tryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010;334:171-81.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 171-181
    • Ishibashi, T.1    Horisawa, T.2    Tokuda, K.3
  • 80
    • 80053933492 scopus 로고    scopus 로고
    • Comment on the potential utility of the new atypical antipsychotic lurasidone in the geriatric population
    • 21840821 10.4140/TCP.n.2011.579
    • Guay DR. Comment on the potential utility of the new atypical antipsychotic lurasidone in the geriatric population. Consult Pharm. 2011;26(8):579-82.
    • (2011) Consult Pharm , vol.26 , Issue.8 , pp. 579-582
    • Guay, D.R.1
  • 81
    • 78650662417 scopus 로고    scopus 로고
    • Lurasidone for schizophrenia: A review of the efficacy and safety profile for this newly approved second-generation antipsychotic
    • 10.1111/j.1742-1241.2010.02587.x 1:CAS:528:DC%2BC3MXjt1WqtLg%3D
    • Citrome L. Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second-generation antipsychotic. Intl J Clin Pract. 2011;65(2):189-210.
    • (2011) Intl J Clin Pract , vol.65 , Issue.2 , pp. 189-210
    • Citrome, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.