MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway

Medical Hypotheses

Volumn 80, Issue 3, 2013, Pages 325-326

  Slaby, Ondrej ^a  

^a CENTRAL EUROPEAN INSTITUTE OF TECHNOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; MICRORNA; MICRORNA 190; PROTEIN TYROSINE KINASE A; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANGIOGENESIS; CANCER CHEMOTHERAPY; CELL DIFFERENTIATION; CHROMOSOME 11Q; CHROMOSOME 14Q; CHROMOSOME 17Q; CHROMOSOME 1P; CHROMOSOME 3P; HUMAN; LETTER; NEUROBLASTOMA; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; RNA DEGRADATION; SIGNAL TRANSDUCTION;

CHROMOSOME MAPPING; COMPARATIVE GENOMIC HYBRIDIZATION; HUMANS; MICRORNAS; NEUROBLASTOMA; PHENOTYPE; RECEPTOR, TRKB;

EID: 84874534731     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.11.033     Document Type: Letter

References (9)

1. Speleman F., De Preter K., Vandesompele J. Neuroblastoma genetics and phenotype: a tale of heterogeneity. Semin Cancer Biol 2011, 21(4):238-244.
2. Brodeur G.M., Minturn J.E., Ho R., Simpson A.M., Iyer R., Varela C.R., et al. Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res 2009, 15(10):3244-3250.
3. Iorio M.V., Croce C.M. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 2012, 4(3):143-159.
4. Lin R.J., Lin Y.C., Chen J., Kuo H.H., Chen Y.Y., Diccianni M.B., et al. MicroRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Clin Cancer Res 2010, 70(20):7841-7850.
5. Bray I., Bryan K., Prenter S., Buckley P.G., Foley N.H., Murphy D.M., et al. Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival. PLoS One 2009, 4(11):e7850.
6. Buckley P.G., Alcock L., Bryan K., Bray I., Schulte J.H., Schramm A., et al. Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q-neuroblastoma. Clin Cancer Res 2010, 16(11):2971-2978.
7. De Preter K., Mestdagh P., Vermeulen J., Zeka F., Naranjo A., Bray I., et al. miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples. Clin Cancer Res 2011, 17(24):7684-7692.
8. Zheng H., Zeng Y., Zhang X., Chu J., Loh H.H., Law P.Y. μ-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Mol Pharmacol 2009, 77(1):102-109.
9. Liu Y., Encinas M., Comella J.X., Aldea M., Gallego C. Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. Mol Cell Biol 2004, 24(7):2662-2672.