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Volumn 8, Issue 2, 2013, Pages

Micro-MRI Study of Cerebral Aging: Ex Vivo Detection of Hippocampal Subfield Reorganization, Microhemorrhages and Amyloid Plaques in Mouse Lemur Primates

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; AGED; AGING; AMYLOID PLAQUE; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN HEMORRHAGE; DENTATE GYRUS; EX VIVO STUDY; HIPPOCAMPUS; LEMURIDAE; MICROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; QUANTITATIVE ANALYSIS;

EID: 84874529261     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056593     Document Type: Article
Times cited : (20)

References (54)
  • 1
    • 0033837078 scopus 로고    scopus 로고
    • Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers
    • Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, et al. (2000) Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology 216: 672-682.
    • (2000) Radiology , vol.216 , pp. 672-682
    • Courchesne, E.1    Chisum, H.J.2    Townsend, J.3    Cowles, A.4    Covington, J.5
  • 2
    • 0018179022 scopus 로고
    • Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights
    • Dekaban AS, (1978) Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol 4: 345-356.
    • (1978) Ann Neurol , vol.4 , pp. 345-356
    • Dekaban, A.S.1
  • 3
    • 30344432109 scopus 로고    scopus 로고
    • Cerebral cortex: an MRI-based study of volume and variance with age and sex
    • Carne RP, Vogrin S, Litewka L, Cook MJ, (2006) Cerebral cortex: an MRI-based study of volume and variance with age and sex. J Clin Neurosci 13: 60-72.
    • (2006) J Clin Neurosci , vol.13 , pp. 60-72
    • Carne, R.P.1    Vogrin, S.2    Litewka, L.3    Cook, M.J.4
  • 4
    • 0029816888 scopus 로고    scopus 로고
    • Hippocampal formation size predicts declining memory performance in normal aging
    • Golomb J, Kluger A, de Leon MJ, Ferris SH, Mittelman M, et al. (1996) Hippocampal formation size predicts declining memory performance in normal aging. Neurology 47: 810-813.
    • (1996) Neurology , vol.47 , pp. 810-813
    • Golomb, J.1    Kluger, A.2    de Leon, M.J.3    Ferris, S.H.4    Mittelman, M.5
  • 5
    • 0031919190 scopus 로고    scopus 로고
    • Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging
    • Raz N, Gunning-Dixon FM, Head D, Dupuis JH, Acker JD, (1998) Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging. Neuropsychology 12: 95-114.
    • (1998) Neuropsychology , vol.12 , pp. 95-114
    • Raz, N.1    Gunning-Dixon, F.M.2    Head, D.3    Dupuis, J.H.4    Acker, J.D.5
  • 6
    • 0026759348 scopus 로고
    • Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates
    • Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, et al. (1992) Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55: 967-972.
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 967-972
    • Scheltens, P.1    Leys, D.2    Barkhof, F.3    Huglo, D.4    Weinstein, H.C.5
  • 7
    • 0026597219 scopus 로고
    • MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease
    • Jack CR Jr, Petersen RC, O'Brien PC, Tangalos EG, (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology 42: 183-188.
    • (1992) Neurology , vol.42 , pp. 183-188
    • Jack Jr., C.R.1    Petersen, R.C.2    O'Brien, P.C.3    Tangalos, E.G.4
  • 8
    • 36949016215 scopus 로고    scopus 로고
    • Alzheimer disease models and human neuropathology: similarities and differences
    • Duyckaerts C, Potier MC, Delatour B, (2008) Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol 115: 5-38.
    • (2008) Acta Neuropathol , vol.115 , pp. 5-38
    • Duyckaerts, C.1    Potier, M.C.2    Delatour, B.3
  • 9
    • 0031110407 scopus 로고    scopus 로고
    • Change in photoperiodic cycle affects life span in a prosimian primate (Microcebus murinus)
    • Perret M, (1997) Change in photoperiodic cycle affects life span in a prosimian primate (Microcebus murinus). J Biol Rhythms 12: 136-145.
    • (1997) J Biol Rhythms , vol.12 , pp. 136-145
    • Perret, M.1
  • 10
    • 33644761191 scopus 로고    scopus 로고
    • Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease?
    • Bons N, Rieger F, Prudhomme D, Fisher A, Krause KH, (2006) Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease? Genes Brain Behav 5: 120-130.
    • (2006) Genes Brain Behav , vol.5 , pp. 120-130
    • Bons, N.1    Rieger, F.2    Prudhomme, D.3    Fisher, A.4    Krause, K.H.5
  • 11
    • 0026567177 scopus 로고
    • Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus
    • Bons N, Mestre N, Petter A, (1992) Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus. Neurobiol Aging 13: 99-105.
    • (1992) Neurobiol Aging , vol.13 , pp. 99-105
    • Bons, N.1    Mestre, N.2    Petter, A.3
  • 12
    • 0031980465 scopus 로고    scopus 로고
    • Cerebral T2-weighted signal decrease during aging in the mouse lemur primate reflects iron accumulation
    • Dhenain M, Duyckaerts C, Michot JL, Volk A, Picq JL, et al. (1998) Cerebral T2-weighted signal decrease during aging in the mouse lemur primate reflects iron accumulation. Neurobiol Aging 19: 65-69.
    • (1998) Neurobiol Aging , vol.19 , pp. 65-69
    • Dhenain, M.1    Duyckaerts, C.2    Michot, J.L.3    Volk, A.4    Picq, J.L.5
  • 13
    • 0030751791 scopus 로고    scopus 로고
    • Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus
    • Giannakopoulos P, Silhol S, Jallageas V, Mallet J, Bons N, et al. (1997) Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus. Acta Neuropathol 94: 131-139.
    • (1997) Acta Neuropathol , vol.94 , pp. 131-139
    • Giannakopoulos, P.1    Silhol, S.2    Jallageas, V.3    Mallet, J.4    Bons, N.5
  • 15
    • 0030693927 scopus 로고    scopus 로고
    • T2-weighted MRI studies of mouse lemurs: a primate model of brain aging
    • Dhenain M, Michot JL, Volk A, Picq JL, Boller F, (1997) T2-weighted MRI studies of mouse lemurs: a primate model of brain aging. Neurobiol Aging 18: 517-521.
    • (1997) Neurobiol Aging , vol.18 , pp. 517-521
    • Dhenain, M.1    Michot, J.L.2    Volk, A.3    Picq, J.L.4    Boller, F.5
  • 17
    • 0242322616 scopus 로고    scopus 로고
    • Regional atrophy in the brain of lissencephalic mouse lemur primates: measurement by automatic histogram-based segmentation of MR images
    • Dhenain M, Chenu E, Hisley CK, Aujard F, Volk A, (2003) Regional atrophy in the brain of lissencephalic mouse lemur primates: measurement by automatic histogram-based segmentation of MR images. Magn Reson Med 50: 984-992.
    • (2003) Magn Reson Med , vol.50 , pp. 984-992
    • Dhenain, M.1    Chenu, E.2    Hisley, C.K.3    Aujard, F.4    Volk, A.5
  • 18
    • 84859485525 scopus 로고    scopus 로고
    • Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments
    • Picq JL, Aujard F, Volk A, Dhenain M, (2012) Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments. Neurobiol Aging 33: 1096-1109.
    • (2012) Neurobiol Aging , vol.33 , pp. 1096-1109
    • Picq, J.L.1    Aujard, F.2    Volk, A.3    Dhenain, M.4
  • 20
    • 33747775155 scopus 로고    scopus 로고
    • Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta)
    • Shamy JL, Buonocore MH, Makaron LM, Amaral DG, Barnes CA, et al. (2006) Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta). Neurobiol Aging 27: 1405-1415.
    • (2006) Neurobiol Aging , vol.27 , pp. 1405-1415
    • Shamy, J.L.1    Buonocore, M.H.2    Makaron, L.M.3    Amaral, D.G.4    Barnes, C.A.5
  • 21
    • 49349116638 scopus 로고    scopus 로고
    • An MRI study of age-related white and gray matter volume changes in the rhesus monkey
    • Wisco JJ, Killiany RJ, Guttmann CR, Warfield SK, Moss MB, et al. (2008) An MRI study of age-related white and gray matter volume changes in the rhesus monkey. Neurobiol Aging 29: 1563-1575.
    • (2008) Neurobiol Aging , vol.29 , pp. 1563-1575
    • Wisco, J.J.1    Killiany, R.J.2    Guttmann, C.R.3    Warfield, S.K.4    Moss, M.B.5
  • 23
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West MJ, Coleman PD, Flood DG, Troncoso JC, (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344: 769-772.
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 24
    • 0028864025 scopus 로고
    • Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease
    • Fukutani Y, Kobayashi K, Nakamura I, Watanabe K, Isaki K, et al. (1995) Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease. Neurosci Lett 200: 57-60.
    • (1995) Neurosci Lett , vol.200 , pp. 57-60
    • Fukutani, Y.1    Kobayashi, K.2    Nakamura, I.3    Watanabe, K.4    Isaki, K.5
  • 25
    • 0032951044 scopus 로고    scopus 로고
    • Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease
    • Small SA, Perera GM, DeLaPaz R, Mayeux R, Stern Y, (1999) Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease. Ann Neurol 45: 466-472.
    • (1999) Ann Neurol , vol.45 , pp. 466-472
    • Small, S.A.1    Perera, G.M.2    DeLaPaz, R.3    Mayeux, R.4    Stern, Y.5
  • 26
    • 77956277498 scopus 로고    scopus 로고
    • Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease
    • Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, et al. (2010) Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 31: 1339-1347.
    • (2010) Hum Brain Mapp , vol.31 , pp. 1339-1347
    • Mueller, S.G.1    Schuff, N.2    Yaffe, K.3    Madison, C.4    Miller, B.5
  • 27
    • 66249113871 scopus 로고    scopus 로고
    • Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields
    • Mueller SG, Weiner MW, (2009) Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields. Hippocampus 19: 558-564.
    • (2009) Hippocampus , vol.19 , pp. 558-564
    • Mueller, S.G.1    Weiner, M.W.2
  • 28
    • 84863952177 scopus 로고    scopus 로고
    • In vivo Analysis of Hippocampal Subfield Atrophy in Mild Cognitive Impairment via Semi-Automatic Segmentation of T2-Weighted MRI
    • Pluta J, Yushkevich P, Das S, Wolk D, (2012) In vivo Analysis of Hippocampal Subfield Atrophy in Mild Cognitive Impairment via Semi-Automatic Segmentation of T2-Weighted MRI. J Alzheimers Dis 31: 85-99.
    • (2012) J Alzheimers Dis , vol.31 , pp. 85-99
    • Pluta, J.1    Yushkevich, P.2    Das, S.3    Wolk, D.4
  • 29
    • 33644809258 scopus 로고    scopus 로고
    • Passive staining: a novel ex vivo MRI protocol to detect amyloid deposits in mouse models of Alzheimer's disease
    • Dhenain M, Delatour B, Walczak C, Volk A, (2006) Passive staining: a novel ex vivo MRI protocol to detect amyloid deposits in mouse models of Alzheimer's disease. Magn Reson Med 55: 687-693.
    • (2006) Magn Reson Med , vol.55 , pp. 687-693
    • Dhenain, M.1    Delatour, B.2    Walczak, C.3    Volk, A.4
  • 30
    • 0035871424 scopus 로고    scopus 로고
    • Three-dimensional digital mouse atlas using high-resolution MRI
    • Dhenain M, Ruffins SW, Jacobs RE, (2001) Three-dimensional digital mouse atlas using high-resolution MRI. Dev Biol 232: 458-470.
    • (2001) Dev Biol , vol.232 , pp. 458-470
    • Dhenain, M.1    Ruffins, S.W.2    Jacobs, R.E.3
  • 31
    • 84861872893 scopus 로고    scopus 로고
    • Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice
    • Petiet A, Santin M, Bertrand A, Wiggins CJ, Petit F, et al. (2012) Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice. Neurobiol Aging 33: 1533-1544.
    • (2012) Neurobiol Aging , vol.33 , pp. 1533-1544
    • Petiet, A.1    Santin, M.2    Bertrand, A.3    Wiggins, C.J.4    Petit, F.5
  • 33
    • 34547805719 scopus 로고    scopus 로고
    • Transverse relaxation time reflects brain amyloidosis in young APP/PS1 transgenic mice
    • El Tayara Nel T, Volk A, Dhenain M, Delatour B, (2007) Transverse relaxation time reflects brain amyloidosis in young APP/PS1 transgenic mice. Magn Reson Med 58: 179-184.
    • (2007) Magn Reson Med , vol.58 , pp. 179-184
    • El Tayara Nel, T.1    Volk, A.2    Dhenain, M.3    Delatour, B.4
  • 34
    • 0032761797 scopus 로고    scopus 로고
    • The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease
    • Bobinski M, de Leon MJ, Wegiel J, Desanti S, Convit A, et al. (2000) The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience 95: 721-725.
    • (2000) Neuroscience , vol.95 , pp. 721-725
    • Bobinski, M.1    de Leon, M.J.2    Wegiel, J.3    Desanti, S.4    Convit, A.5
  • 35
    • 84862502246 scopus 로고    scopus 로고
    • Distortion in formalin-fixed brains: using geometric morphometrics to quantify the worst-case scenario in mice
    • Weisbecker V, (2012) Distortion in formalin-fixed brains: using geometric morphometrics to quantify the worst-case scenario in mice. Brain Struct Funct 217: 677-685.
    • (2012) Brain Struct Funct , vol.217 , pp. 677-685
    • Weisbecker, V.1
  • 36
    • 0019509193 scopus 로고
    • Effects of aging on formalin-fixed brain weight in mice and rats
    • Douglas RJ, Clark GM, Truncer PC, Treneer CM, (1981) Effects of aging on formalin-fixed brain weight in mice and rats. Gerontology 27: 127-132.
    • (1981) Gerontology , vol.27 , pp. 127-132
    • Douglas, R.J.1    Clark, G.M.2    Truncer, P.C.3    Treneer, C.M.4
  • 38
    • 0014017136 scopus 로고
    • Further observations on age differences in the effects of formalin on the canine brain in vitro
    • Fox MW, (1966) Further observations on age differences in the effects of formalin on the canine brain in vitro. Experientia 22: 447-448.
    • (1966) Experientia , vol.22 , pp. 447-448
    • Fox, M.W.1
  • 39
    • 84860390384 scopus 로고    scopus 로고
    • The grey mouse lemur: a non-human primate model for ageing studies
    • Languille S, Blanc S, Blin O, Canale CI, Dal-Pan A, et al. (2012) The grey mouse lemur: a non-human primate model for ageing studies. Ageing Res Rev 11: 150-162.
    • (2012) Ageing Res Rev , vol.11 , pp. 150-162
    • Languille, S.1    Blanc, S.2    Blin, O.3    Canale, C.I.4    Dal-Pan, A.5
  • 40
    • 67650505038 scopus 로고    scopus 로고
    • Neurobiological changes in the hippocampus during normative aging
    • Lister JP, Barnes CA, (2009) Neurobiological changes in the hippocampus during normative aging. Arch Neurol 66: 829-833.
    • (2009) Arch Neurol , vol.66 , pp. 829-833
    • Lister, J.P.1    Barnes, C.A.2
  • 41
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn HG, Dickinson-Anson H, Gage FH, (1996) Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 16: 2027-2033.
    • (1996) J Neurosci , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 43
    • 0030438734 scopus 로고    scopus 로고
    • The adult rat hippocampus contains primordial neural stem cells
    • Palmer TD, Takahashi J, Gage FH, (1997) The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8: 389-404.
    • (1997) Mol Cell Neurosci , vol.8 , pp. 389-404
    • Palmer, T.D.1    Takahashi, J.2    Gage, F.H.3
  • 45
    • 33847375974 scopus 로고    scopus 로고
    • Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T
    • Mueller SG, Stables L, Du AT, Schuff N, Truran D, et al. (2007) Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Neurobiol Aging 28: 719-726.
    • (2007) Neurobiol Aging , vol.28 , pp. 719-726
    • Mueller, S.G.1    Stables, L.2    Du, A.T.3    Schuff, N.4    Truran, D.5
  • 46
    • 78649555789 scopus 로고    scopus 로고
    • Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice
    • Luo F, Rustay NR, Seifert T, Roesner B, Hradil V, et al. (2010) Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice. J Pharmacol Exp Ther 335: 580-588.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 580-588
    • Luo, F.1    Rustay, N.R.2    Seifert, T.3    Roesner, B.4    Hradil, V.5
  • 47
    • 28044448943 scopus 로고    scopus 로고
    • Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex
    • Cullen KM, Kocsi Z, Stone J, (2005) Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. J Cereb Blood Flow Metab 25: 1656-1667.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1656-1667
    • Cullen, K.M.1    Kocsi, Z.2    Stone, J.3
  • 48
    • 80053966811 scopus 로고    scopus 로고
    • Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study
    • Lee SH, Lee ST, Kim BJ, Park HK, Kim CK, et al. (2011) Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study. PLoS One 6: e25930.
    • (2011) PLoS One , vol.6
    • Lee, S.H.1    Lee, S.T.2    Kim, B.J.3    Park, H.K.4    Kim, C.K.5
  • 49
    • 4243157452 scopus 로고    scopus 로고
    • Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents
    • Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA, (2004) Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med 52: 538-544.
    • (2004) Magn Reson Med , vol.52 , pp. 538-544
    • Lee, S.P.1    Falangola, M.F.2    Nixon, R.A.3    Duff, K.4    Helpern, J.A.5
  • 50
    • 10044278300 scopus 로고    scopus 로고
    • In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent
    • Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, et al. (2004) In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magn Reson Med 52: 1263-1271.
    • (2004) Magn Reson Med , vol.52 , pp. 1263-1271
    • Jack Jr., C.R.1    Garwood, M.2    Wengenack, T.M.3    Borowski, B.4    Curran, G.L.5
  • 51
    • 0036091386 scopus 로고    scopus 로고
    • Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images
    • Dhenain M, Privat N, Duyckaerts C, Jacobs RE, (2002) Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed 15: 197-203.
    • (2002) NMR Biomed , vol.15 , pp. 197-203
    • Dhenain, M.1    Privat, N.2    Duyckaerts, C.3    Jacobs, R.E.4
  • 53
    • 66149090377 scopus 로고    scopus 로고
    • MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
    • Meadowcroft MD, Connor JR, Smith MB, Yang QX, (2009) MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. J Magn Reson Imaging 29: 997-1007.
    • (2009) J Magn Reson Imaging , vol.29 , pp. 997-1007
    • Meadowcroft, M.D.1    Connor, J.R.2    Smith, M.B.3    Yang, Q.X.4
  • 54
    • 58549089731 scopus 로고    scopus 로고
    • Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives
    • Trouche SG, Asuni A, Rouland S, Wisniewski T, Frangione B, et al. (2009) Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine 27: 957-964.
    • (2009) Vaccine , vol.27 , pp. 957-964
    • Trouche, S.G.1    Asuni, A.2    Rouland, S.3    Wisniewski, T.4    Frangione, B.5


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