Aluminum may mediate Alzheimer's disease through liver toxicity, with aberrant hepatic synthesis of ceruloplasmin and ATPase7B, the resultant excess free copper causing brain oxidation, beta-amyloid aggregation and Alzheimer disease

Medical Hypotheses

Volumn 80, Issue 3, 2013, Pages 326-327

  Brenner, Steven ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE 7B; ALUMINUM; AMYLOID BETA PROTEIN; CERULOPLASMIN; COPPER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; COPPER BLOOD LEVEL; DISEASE COURSE; LETTER; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; OXIDATION; PROTEIN AGGREGATION; PROTEIN SYNTHESIS;

ADENOSINE TRIPHOSPHATASES; ALUMINUM; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BRAIN; CERULOPLASMIN; HUMANS; LIVER; MODELS, THEORETICAL; OXIDATION-REDUCTION;

EID: 84874524385     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.11.036     Document Type: Letter

References (5)

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