메뉴 건너뛰기




Volumn , Issue , 2021, Pages 8-31

The importance of the physicochemical properties of drugs to drug metabolism

(1)  Spalding, David a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84874448155     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (2)

References (41)
  • 2
    • 0021278122 scopus 로고
    • Binding of oxprenolol and propranolol to serum albumin and α1-acid glycoprotein in man and other species
    • Belpaire, F.M., Braeckman, R.A. and Bogaert, M.G. (1984) Binding of oxprenolol and propranolol to serum albumin and α1-acid glycoprotein in man and other species. Biochem. Pharmacol. 33, 2065-2069.
    • (1984) Biochem. Pharmacol , vol.33 , pp. 2065-2069
    • Belpaire, F.M.1    Braeckman, R.A.2    Bogaert, M.G.3
  • 3
    • 0024532544 scopus 로고
    • Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as a racemate
    • Borgstrom, L., Nyberg, L., Jonsson, S., Linberg, C. and Paulson, J. (1989) Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as a racemate. Br. J. Clin. Pharmcol. 27, 49-56.
    • (1989) Br. J. Clin. Pharmcol , vol.27 , pp. 49-56
    • Borgstrom, L.1    Nyberg, L.2    Jonsson, S.3    Linberg, C.4    Paulson, J.5
  • 4
    • 0023017975 scopus 로고
    • Determination of hydrophobic parameters by reversed-phase liquid chromatography: Theory, experimental techniques and applications in studies on quantitative structure activity relationships
    • Brauman, T. (1986) Determination of hydrophobic parameters by reversed-phase liquid chromatography: theory, experimental techniques and applications in studies on quantitative structure activity relationships. J. Chromatogr. 373, 191-225.
    • (1986) J. Chromatogr , vol.373 , pp. 191-225
    • Brauman, T.1
  • 5
    • 84909777464 scopus 로고
    • Drug-serum protein binding interactions and their biological significance
    • Bridges, J.W. and Chasseaud, L.F. (eds), Wiley Interscience, London
    • Bridges, J.W. and Wilson, A.G.E. (1977) Drug-serum protein binding interactions and their biological significance. In: Progress in Drug Metabolism, Vol. 2, pp. 193-247, Bridges, J.W. and Chasseaud, L.F. (eds), Wiley Interscience, London.
    • (1977) Progress in Drug Metabolism , vol.2 , pp. 193-247
    • Bridges, J.W.1    Wilson, A.G.E.2
  • 7
    • 0020081135 scopus 로고
    • Electrical resistance of brain microvascular endothelium
    • Crone, C. and Olensen, S.P. (1982) Electrical resistance of brain microvascular endothelium. Brain Res. 241, 49-55.
    • (1982) Brain Res , vol.241 , pp. 49-55
    • Crone, C.1    Olensen, S.P.2
  • 9
    • 85133909762 scopus 로고
    • Pharmacokinetics of (+)-, (-)- and (±) verapamil after intravenous administration
    • Eichelbaum, M., Mikus, G. and Vogelsang, B. (1984) Pharmacokinetics of (+)-, (-)- and (±) verapamil after intravenous administration. Br. J. Clin. Pharmacol. 18, 733-740.
    • (1984) Br. J. Clin. Pharmacol , vol.18 , pp. 733-740
    • Eichelbaum, M.1    Mikus, G.2    Vogelsang, B.3
  • 11
    • 0026437190 scopus 로고
    • Policy statement for the development of new stereoisomeric drugs
    • Food and Drug Administration (1992) Policy statement for the development of new stereoisomeric drugs. Chirality 4, 338-340.
    • (1992) Chirality , vol.4 , pp. 338-340
  • 13
    • 0025307009 scopus 로고
    • Mechanisms of cytochrome P-450 catalysis
    • Guengerich, F.P. and MacDonald, T.L. (1990) Mechanisms of cytochrome P-450 catalysis. FASEB J. 4, 2453-2459.
    • (1990) FASEB J , vol.4 , pp. 2453-2459
    • Guengerich, F.P.1    MacDonald, T.L.2
  • 14
    • 0016907469 scopus 로고
    • On the structure of medicinal chemistry
    • Hansch, C. (1976) On the structure of medicinal chemistry. J. Med. Chem. 19, 1-6.
    • (1976) J. Med. Chem , vol.19 , pp. 1-6
    • Hansch, C.1
  • 15
    • 0022545904 scopus 로고
    • A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase
    • May
    • Hansch, C., Klein, T., McClarin, J., Langridge, R. and Cornell, N.W. (1986) A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase. J. Med. Chem. May, 29(5), 615-620.
    • (1986) J. Med. Chem , vol.29 , Issue.5 , pp. 615-620
    • Hansch, C.1    Klein, T.2    McClarin, J.3    Langridge, R.4    Cornell, N.W.5
  • 16
    • 0021359208 scopus 로고
    • Entero-hepatic cycling of methotrexate estimated by use of the D-isomer as a reference marker
    • Hendel, J. and Brodthages, H. (1984) Entero-hepatic cycling of methotrexate estimated by use of the D-isomer as a reference marker. Eur. J. Clin. Pharmacol. 26, 103-107.
    • (1984) Eur. J. Clin. Pharmacol , vol.26 , pp. 103-107
    • Hendel, J.1    Brodthages, H.2
  • 17
    • 0013586201 scopus 로고
    • Gastrointestinal absorption of drugs and other xenobio-tics
    • Bridges, J.W. and Chasseaud, L.F. (eds), John Wiley & Sons, London
    • Houston, J.B. and Wood, S.G. (1980) Gastrointestinal absorption of drugs and other xenobio-tics. In: Progress in Drug Metabolism, Vol. 4, pp. 57-129, Bridges, J.W. and Chasseaud, L.F. (eds), John Wiley & Sons, London.
    • (1980) Progress in Drug Metabolism , vol.4 , pp. 57-129
    • Houston, J.B.1    Wood, S.G.2
  • 18
    • 0003630656 scopus 로고
    • Central nervous penetration of drugs: Importance of physicochemical properties
    • Gibson, G.G. (ed.), Taylor & Francis, London
    • Jezequel, S.G. (1992) Central nervous penetration of drugs: importance of physicochemical properties. In: Progress in Drug Metabolism, Vol. 13, pp. 141-178, Gibson, G.G. (ed.), Taylor & Francis, London.
    • (1992) Progress in Drug Metabolism , vol.13 , pp. 141-178
    • Jezequel, S.G.1
  • 19
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology and biochemistry of humans and commonly used laboratory animals
    • Kararli, T.T. (1995) Comparison of the gastrointestinal anatomy, physiology and biochemistry of humans and commonly used laboratory animals. Biopharm. Drug Dispos. 16, 351-380.
    • (1995) Biopharm. Drug Dispos , vol.16 , pp. 351-380
    • Kararli, T.T.1
  • 20
    • 0025263883 scopus 로고
    • Chirality: Clinical pharmacokinetics and pharmaco-dynamic considerations
    • Lee, E.J.D. and Williams, K.M. (1990) Chirality: clinical pharmacokinetics and pharmaco-dynamic considerations. Clin. Pharmacokinet. 18, 339-345.
    • (1990) Clin. Pharmacokinet , vol.18 , pp. 339-345
    • Lee, E.J.D.1    Williams, K.M.2
  • 21
    • 0022351887 scopus 로고
    • Stereoselective pharmacokinetics of disopyr-amide enantiomers in man
    • Lima, J.J., Boudoulas, H. and Shields, B.J. (1985) Stereoselective pharmacokinetics of disopyr-amide enantiomers in man. Drug Metab. Dispos. 13, 572-577.
    • (1985) Drug Metab. Dispos , vol.13 , pp. 572-577
    • Lima, J.J.1    Boudoulas, H.2    Shields, B.J.3
  • 22
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3-25.
    • (1997) Adv. Drug Deliv. Rev , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 25
    • 0029065530 scopus 로고
    • Membrane partition coefficients chromatographically measured using immobilised artificial membrane surfaces
    • Ong, S., Liu, H., Qiu, X., Bhat, G. and Pidgeon, C. (1995) Membrane partition coefficients chromatographically measured using immobilised artificial membrane surfaces. Anal. Chem. 67, 755-762.
    • (1995) Anal. Chem , vol.67 , pp. 755-762
    • Ong, S.1    Liu, H.2    Qiu, X.3    Bhat, G.4    Pidgeon, C.5
  • 26
    • 0018650290 scopus 로고
    • Carrier mediated transport of thyroid hormones through the rat blood -brain barrier: Primary role of albumin bound hormone
    • Pardridge, W.M. (1979) Carrier mediated transport of thyroid hormones through the rat blood -brain barrier: primary role of albumin bound hormone. Endocrinology 105 605-612.
    • (1979) Endocrinology , vol.105 , pp. 605-612
    • Pardridge, W.M.1
  • 27
    • 0023951327 scopus 로고
    • Recent advances in blood-brain barrier transport
    • Pardridge, W.M. (1988) Recent advances in blood-brain barrier transport. Ann. Rev. Pharmacol. Toxicol. 28, 25-39.
    • (1988) Ann. Rev. Pharmacol. Toxicol , vol.28 , pp. 25-39
    • Pardridge, W.M.1
  • 29
    • 0013772855 scopus 로고
    • Physiological transport of drugs
    • Schanker, L.S. (1964) Physiological transport of drugs. Adv. Drug Res. 1, 71-106.
    • (1964) Adv. Drug Res , vol.1 , pp. 71-106
    • Schanker, L.S.1
  • 30
    • 0017347179 scopus 로고
    • Use of distribution coefficients in quantitative structure/activity relationships
    • Scherrer, R.A. and Howard, S.M. (1977) Use of distribution coefficients in quantitative structure/activity relationships. J. Med. Chem. 20, 53-58.
    • (1977) J. Med. Chem , vol.20 , pp. 53-58
    • Scherrer, R.A.1    Howard, S.M.2
  • 31
    • 80053629474 scopus 로고
    • The analysis of electronic factors in quantitative structure/activity relationships using distribution coefficients
    • ACS Symposium Series, No. 112
    • Scherrer, R.A. and Howard, S.M. (1979) The analysis of electronic factors in quantitative structure/activity relationships using distribution coefficients. In: Computer-Assisted Drug Design.ACS Symposium Series, No. 112, pp. 507-526
    • (1979) Computer-Assisted Drug Design , pp. 507-526
    • Scherrer, R.A.1    Howard, S.M.2
  • 32
    • 0027946920 scopus 로고
    • Design of drugs through a consideration of drug metabolism and pharmacokinetics
    • Smith, D.A. (1994) Design of drugs through a consideration of drug metabolism and pharmacokinetics. Eur. J. Drug Metab. Pharmacokinet. 3, 193-199.
    • (1994) Eur. J. Drug Metab. Pharmacokinet , vol.3 , pp. 193-199
    • Smith, D.A.1
  • 33
    • 0016722069 scopus 로고
    • Selection of a reference partitioning system for drug design work
    • Smith, R.N., Hansch, C. and Ames, M.M. (1975) Selection of a reference partitioning system for drug design work. J. Pharm. Sci. 64, 599-606.
    • (1975) J. Pharm. Sci , vol.64 , pp. 599-606
    • Smith, R.N.1    Hansch, C.2    Ames, M.M.3
  • 35
    • 0023105521 scopus 로고
    • Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in man
    • Toon, S., Hopkins, K.J., Garstang, F.M. and Rowland, M. (1987) Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in man. Eur. J. Clin. Pharmacol. 32, 165-172.
    • (1987) Eur. J. Clin. Pharmacol , vol.32 , pp. 165-172
    • Toon, S.1    Hopkins, K.J.2    Garstang, F.M.3    Rowland, M.4
  • 37
    • 0028904527 scopus 로고
    • Stereochemistry in pharmacotherapy: When mirror images are not identical
    • Tracy, T.S. (1995) Stereochemistry in pharmacotherapy: when mirror images are not identical. Ann. Pharmacother. 29, 161-165.
    • (1995) Ann. Pharmacother , vol.29 , pp. 161-165
    • Tracy, T.S.1
  • 38
    • 0018074241 scopus 로고
    • Simple procedure for determining octanol-aqueous partition, distribution and ionisation coefficients by reversed-phase high pressure liquid chromatography
    • Unger, S.H., Cook, J.R. and Hollenberg, J.S. (1978) Simple procedure for determining octanol-aqueous partition, distribution and ionisation coefficients by reversed-phase high pressure liquid chromatography. J. Pharm. Sci. 67, 1364-1367.
    • (1978) J. Pharm. Sci , vol.67 , pp. 1364-1367
    • Unger, S.H.1    Cook, J.R.2    Hollenberg, J.S.3
  • 39
    • 0021713528 scopus 로고
    • Stereoselective first-pass metabolism of highly cleared drugs: Studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique
    • Vogelsang, B., Echizen, H., Schmidt, E. and Eichelbaum, M. (1984) Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique. Br. J. Clin. Pharmacol. 18, 733-740.
    • (1984) Br. J. Clin. Pharmacol , vol.18 , pp. 733-740
    • Vogelsang, B.1    Echizen, H.2    Schmidt, E.3    Eichelbaum, M.4
  • 41
    • 0025220065 scopus 로고
    • Effect of fat tissue volume on the distribution kinetics ofbiperidin as a function ofage in rats
    • Yokogawa, K., Nakashima, E. and Ichimura, F. (1990) Effect of fat tissue volume on the distribution kinetics ofbiperidin as a function ofage in rats. DrugMetab. Dispos. 18, 258-263.
    • (1990) DrugMetab. Dispos , vol.18 , pp. 258-263
    • Yokogawa, K.1    Nakashima, E.2    Ichimura, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.