Pathological changes of the anatomical structure and markers of the limbal stem cell niche due to inflammation

Molecular Vision

Volumn 19, Issue , 2013, Pages 516-525

  Nubile, Mario ^a   Curcio, Claudia ^a   Dua, Harminder S ^b   Calienno, Roberta ^a   Lanzini, Manuela ^a   Iezzi, Manuela ^a   Mastropasqua, Rodolfo ^c   Agnifili, Luca ^a   Mastropasqua, Leonardo ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; BETA1 INTEGRIN; BETA4 INTEGRIN; BREAST CANCER RESISTANCE PROTEIN; CONNEXIN 43; CYTOKERATIN 12; CYTOKERATIN 15; DESMOGLEIN 3; KALININ; NERVE CELL ADHESION MOLECULE; PROTEIN P63; VIMENTIN;

ADULT; AGED; ANATOMICAL CONCEPTS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA LIMBUS; EYE INFLAMMATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL NICHE; STRUCTURE ANALYSIS;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; EYE PROTEINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; KERATITIS; LIMBUS CORNEAE; MIDDLE AGED; STEM CELL NICHE;

EID: 84874437325     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Schlötzer-Schrehardt U, Dietrich T, Saito K, Sorokin L, Sasaki T, Paulsson M, Kruse FE. Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. Exp Eye Res 2007; 85:845-60. [PMID: 17927980]
2. Dua HS, Shanmuganathan VA, Powell-Richards O, Tighe PJ, Joseph A. Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche. Br J Ophthalmol 2005; 89:529-32. [PMID: 15834076]
3. Li W, Hayashida Y, Chen YT, Tseng SCG. Niche regulation of corneal epithelial stem cells at the limbus. Cell Res 2007; 17:26-36. [PMID: 17211449]
4. Yeung AM-H, Schlotzer-Schrehardt U, Kulkarni B, Tini NL, Hopkinson A, Dua HS. Limbal epithelial crypt A model for corneal epithelial maintenance and novel limbal regional variations. Arch Ophthalmol 2008; 126:665-9. [PMID: 18474777].
5. Pajoohesh-Ganji A, Stepp MA. In search of markers for the 0stem cells of the corneal epithelium. Biol Cell 2005; 97:265-76. [PMID: 15762848]
6. Shanmuganathan VA, Foster T, Kulkarni BB, Hopkinson A, Gray T, Powe DG, Lowe J, Dua HS. Morphological char- acteristics of the limbal epithelial crypt. Br J Ophthalmol 2007; 91:514-9. [PMID: 17020899]
7. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, Ponzin D, McKeon F, De Luca M. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 2001; 98:3156-61. [PMID: 11248048]
8. Schlötzer-Schrehardt U, Kruse FE. Identification and characterization of limbal stem cells. Exp Eye Res 2005; 81:247-64. [PMID: 16051216]
9. Shortt AJ, Secker GA, Munro PM, Khaw PT, Tuft SJ, Daniels JT. Characterization of the limbal epithelial stem cell niche: novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cell. Stem Cells 2007; 25:1402-9. [PMID: 17332511]
10. Du Y, Funderburgh ML, Mann MM, SundarRaj N, Funderburgh JL. Multipotent Stem Cells in human corneal stroma. Stem Cells 2005; 23:1266-75. [PMID: 16051989]
11. de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ ABCG2 transporter identifies a populationof clonogenic human limbal epithelial cells. Stem Cells 2005; 23:63-73. [PMID: 15625123]
12. Joseph A, Powell-Richards AOR, Shanmuganathan VA, Dua HS. Epithelial cell characteristics of cultured human limbal explants. Br J Ophthalmol 2004; 88:393-8. [PMID: 14977776]
13. Lavker RM, Tseng SC, Sun TT. Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle. Exp Eye Res 2004; 78:433-46. [PMID: 15106923]
14. Dua HS, Joseph A, Shanmuganathan VA, Jones RE. Stem cell differentiation and the effects of deficiency. Eye (Lond) 2003; 17:877-85. [PMID: 14631392]
15. Espana EM, Di Pascuale MA, He H, Kawakita T, Raju VK, Liu CY, Tseng SC. Characterization of corneal pannus removed from patients with total limbal stem cell deficiency. Invest Ophthalmol Vis Sci 2004; 45:2961-6. [PMID: 15326108]
16. Matic M, Petrov IN, Chen S, Wang C, Dimitrijevich SD, Wolosin JM. Stem cells of the corneal epithelium lack connexins and metabolite transfer capacity. Differentiation 1997; 61:251-60. [PMID: 9203348]
17. Cancelas JA, Koevoet WL, de Koning AE, Mayen AE, Rombouts EJ, Ploemacher RE. Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood 2000; 96:498-505. [PMID: 10887111]
18. Rosendaal M, Green CR, Rahman A, Morgan D. Up-regulation of the connexin43+ gap junction network in haemopoietic tissue before the growth of stem cells. J Cell Sci 1994; 107:29-37. [PMID: 8175916]
19. Wen H, Blume PA, Sumpio BE. Role of integrins and focal adhesion kinase in the orientation of dermal fibroblast exposed to cyclic stain. Int Wound J 2009; 6:149-58. [PMID: 19432665]
20. Schreiber TD, Steinl C, Essi M, Abele H, Geiger K, Muller CA, Aicher WK, Klein G. The integrin α9β1 on hematopoi - etic stem cell progenitor cells: involvement in cell adhesion, proliferation and differentiation. Haematologica 2009; 94:1493-501.:19608669-[PMID: 19797727]
21. Zhou J, Chen F, Xiao J, Li C, Liu Y, Ding Y, Wan P, Wang X, Huang J, Wang Z. Enhanced functional properties of corneal epithelial cells by coculture with embryonic stem cells via the integrin β1-FAK-PI3K/Akt pathway. Int J Biochem Cell Biol 2011; 43:1168-77. [PMID: 21550417]
22. Yeung AM, Tint NL, Kulkarni BB, Mohammed I, Suleman H, Hopkinson A, Dua HS. Infant limbus: an immunological study. Exp Eye Res 2008; 88:1161-4]
23. Ljubimov AV, Burgeson RE, Butkowski RJ, Michael AF, Sun TT, Kenney MC. Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms. Lab Invest 1995; 72:461-73. [PMID: 7723285]
24. Chen W, Garcia JG, Jacobson JR. Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses. J Cell Biochem 2010; 110:718-24. [PMID: 20512931]
25. Dua HS, Miri A, Said DG. Contemporary limbal stem cell transplantation: a review. Clin Experiment Ophthalmol 2010; 38:104-17. [PMID: 20398102]
26. Figueira EC, Di Girolamo N, Coroneo MT, Wakefield D. The phenotype of limbal epithelial stem cells. Invest Ophthalmol Vis Sci 2007; 48:144-56. [PMID: 17197527]
27. Dua HS, Miri A, Alomar T, Yeung AM, Said DG. The role of limbal stem cells in corneal epithelial maintenance: testingthe dogma. Ophthalmology 2009; 116:856-63. [PMID: 19410942].