Unraveling the genetics of inhibitors in hemophilia

Blood

Volumn 121, Issue 8, 2013, Pages 1250-1251

  Gouw, Samantha C ^a   Fijnvandraat, Karin ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; HLA ANTIGEN CLASS 2;

ANTIBODY PRODUCTION; ARTHROPATHY; DISEASE SEVERITY; GENETICS; HEMOPHILIA A; HUMAN; IMMUNE RESPONSE; MORTALITY; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84874435437     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-12-472647     Document Type: Short Survey

References (10)

1. Astermark J, Donfield SM, Gomperts ED, et al. The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort. Blood. 2013;121(8):1446-1454.
2. Ikkala E, Helske T, Myllyla G, et al. Changes in the life expectancy of patients with severe haemophilia A in Finland in 1930-79. Br J Haematol. 1982;52(1):7-12. (Pubitemid 12028601)
3. Mannucci PM, Tuddenbam EG. The hemophilias: progress and problems. Semin Hematol. 1999;36(4 Suppl 7):104-117.
4. Gouw SC, van den Berg HM, Astermark J, et al. F8 gene mutation type and inhibitor development in patients with severe Hemophilia A: systematic review and metaanalysis. Blood. 2012;119(12):2922-2934.
5. Eckhardt CL, van der Bom JG, van der Naald M, Peters M, Kamphuisen PW, Fijnvandraat K. Surgery and inhibitor development in hemophilia A: a systematic review. J Thromb Haemost. 2011;9(10):1948-1958.
6. Astermark J, Oldenburg J, Escobar M, White GC II, Berntorp E, MIBS Study Group. The Malmö International Brother Study (MIBS). Genetic defects and inhibitor development in siblings with severe hemophilia A. Haematologica. 2005;90(7):924-930. (Pubitemid 41020295)
7. Pavlova A, Delev D, Lacroix-Desmazes S, et al. Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxicTlymphocyte antigen-4 genes on inhibitor development in severe hemophilia A. J Thromb Haemost. 2009;7(12):2006-2015.
8. Astermark J, Oldenburg J, Carlson J, et al. Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. Blood. 2006;108(12):3739-3745. (Pubitemid 44864553)
9. Astermark J, Oldenburg J, Pavlova A, Berntorp E, Lefvert AK, MIBS Study Group. Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A. Blood. 2006;107(8):3167-3172.
10. van Helden PM, Van Haren SD, Fijnvandraat K, van den Berg HM, Voorberg J. Factor VIII-specific B cell responses in haemophilia A patients with inhibitors. Haemophilia. 2010;16(102):35-43.