Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture

Integrative Biology (United Kingdom)

Volumn 4, Issue 10, 2012, Pages 1215-1222

  Yamaguchi, Masayoshi ^a,b,c   Weitzmann, M Neale ^c,d   Baile, Clifton A ^b   Murata, Tomiyasu ^e  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

^e MEIJO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; REGUCALCIN; CALCIUM BINDING PROTEIN; RGN PROTEIN, MOUSE; SIGNAL PEPTIDE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE MARROW CULTURE; CELL DIFFERENTIATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; EX VIVO STUDY; FIBROBLAST; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOBLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL LINEAGE; CELL STRAIN 3T3; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; STEM CELL;

3T3 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BONE MARROW CELLS; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STROMAL CELLS; MICE; OSTEOBLASTS; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84874432990     PISSN: 17579694     EISSN: 17579708     Source Type: Journal    
DOI: 10.1039/c2ib20118f     Document Type: Article

References (37)

1. W. Y. Cheung Calmodulin plays a pivotal role in cellular regulation Science 1980 202 19 27
2. Y. Nishizuka Studies and perspectives of protein kinase C Science 1986 233 305 312
3. 2+ in the regulation of gluconeogenesis Metabolism 1996 48 389 403
4. M. Yamaguchi T. Yamamoto Purification of calcium binding substance from soluble fraction of normal rat liver Chem. Pharm. Bull. 1978 26 1915 1918
5. 2+-binding protein regucalcin and calcium inhibition. Regulatory role in liver cell function, in Calcium inhibition, ed., K. Kohama, Japan Science Society Press, Tokyo and CRC Press, Boca Raton, 1992, pp. 19-41
6. N. Shimokawa M. Yamaguchi Molecular cloning and sequencing of the cDNA coding for a calcium-binding protein regucalcin from rat liver FEBS Lett. 1993 327 251 255
7. M. Yamaguchi The transcriptional regulation of regucalcin gene expression Mol. Cell. Biochem. 2011 346 147 171
8. M. Yamaguchi Role of regucalcin in calcium signaling Life Sci. 2000 66 1769 1780
9. M. Yamaguchi The role of regucalcin in nuclear regulation of regenerating liver Biochem. Biophys. Res. Commun. 2000 276 1 6
10. M. Yamaguchi Role of regucalcin in maintaining cell homeostasis and function Int. J. Mol. Med. 2005 15 372 389
11. M. Yamaguchi Regucalcin and cell regulation: role as a suppressor protein in signal transduction Mol. Cell. Biochem. 2011 353 101 137
12. S. S. Laurentino S. Correia J. E. Cavaco P. F. Oliveira M. de Sousa A. Barros S. Socorro Regucalcin, a calcium-binding protein with a role in male reproduction Mol. Hum. Reprod. 2012 18 161 170
13. M. Yamaguchi Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats Mol. Cell. Biochem. 2010 341 119 133
14. M. Yamaguchi H. Misawa S. Uchiyama Y. Morooka Y. Tsurusaki Role of endogenous regucalcin in bone metabolism: bone loss is induced in regucalcin transgenic rats Int. J. Mol. Med. 2002 10 377 383
15. M. Yamaguchi A. Igarashi S. Uchiyama N. Sawada Hyperlipidemia is induced in regucalcin transgenic rats with increasing age Int. J. Mol. Med. 2004 14 647 651
16. M. Yamaguchi N. Sawada S. Uchiyama H. Misawa Z. J. Ma Expression of regucalcin in rat bone marrow cells: involvement of osteoclastic bone resorption in regucalcin transgenic rats Int. J. Mol. Med. 2004 13 437 443
17. S. Uchiyama M. Yamaguchi Bone loss in regucalcin transgenic rats: Enhancement of osteoclastic cell formation from bone marrow of rats with increasing age Int. J. Mol. Med. 2004 14 451 455
18. M. Yamaguchi S. Uchiyama Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures J. Cell. Biochem. 2005 94 794 803
19. M. Yamaguchi M. Kobayashi S. Uchiyama Suppressive effect of regucalcin on cell differentiation and mineralization in osteoblastic MC3T3-E1 cells J. Cell. Biochem. 2005 96 543 554
20. Y. Otomo M. Yamaguchi Regulatory effect of exogenous regucalcin on cell function in osteoblastic MC3T3-E1 cells: Involvement of intracellular signaling factor Int. J. Mol. Med. 2006 18 321 327
21. M. Yamaguchi Y. Otomo S. Uchiyama T. Nakagawa Hormonal regulation of regucalcin mRNA expression in osteoblastic MC3T3-E1 cells Int. J. Mol. Med. 2008 21 771 775
22. M. Yamaguchi M. N. Weitzmann T. Murata Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-κB activation Mol. Cell. Biochem. 2012 359 193 203
23. L. Zhao B. M. Hantash TGF-β1 regulates differentiation of bone marrow mesenchymal stem cells Vitam. Horm. 2011 87 127 141
24. M. Laudes Role of WNT signaling in the determination of human mesenchymal stem cells into preadipocytes J. Mol. Endocrinol. 2011 46 R65 R72
25. K. Janssens P. Ten Dijke S. Janssens W. Van Hul Transforming growth factor-beta1 to the bone Endocr. Rev. 2005 26 743 774
26. F. Zhang T. Qiu X. Wu C. Wan W. Shi Y. Wang J. G. Chen M. Wan T. L. Clemens X. Cao Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation J. Bone Miner. Res. 2009 24 1224 1233
27. P. Ducy R. Zhang V. Geoffroy A. L. Ridall G. Karsenty Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 1997 89 747 754
28. K. Nakashima X. Zhou G. Kunkel Z. Zhang J. M. Deng R. R. Behringer B. de Crombrugghe The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation Cell 2002 108 17 29
29. M. Yamaguchi M. N. Weitzmann Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation Int. J. Mol. Med. 2011 27 3 14
30. W. Zhang G. Ou M. Hamrick W. Hill J. Borke K. Wenger N. Chutkan J. Yu Q.-S. Mi C. M. Isales X.-M. Shi Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells J. Bone Miner. Res. 2008 23 1118 1128
31. N. Hemati S. E. Ross R. L. Erickson M. M. Manson R. A. Walker A. Gescher Signaling pathways through which insulin regulates CCAAT/enhance binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression J. Biol. Chem. 1997 272 25913 25919
32. S. Rayalam M. A. Della-Fera J.-Y. Yang H. J. Park S. Ambati C. A. Baile Resveratrol potentiates genisten's antiadipogenic and proapoptic effects in 3T3-L1 adipocytes J. Nutr. 2007 137 2668 2673
33. M. Yamaguchi M. Isogai Tissue concentration of calcium-binding protein regucalcin in rats by enzyme-linked immunoadsorbent assay Mol. Cell. Biochem. 1993 122 65 68
34. Q. W. Chen L. Edvinsson C. B. Xu Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells BMC Cell Biol. 2009 10 52 64
35. Y. Liu Y. Yang Y. C. Ye Q. F. Shi K. Chai S. Tashiro S. Onodera T. Ikejima Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells J. Phramacol. Sci. 2012 118 423 432
36. S. Muruganandan A. A. Roman C. J. Sinal Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program Cell. Mol. Life Sci. 2009 66 236 253
37. 2+)-adenosine triphosphatase in the plasma membranes of rat liver Chem. Pharm. Bull. 1988 36 3532 3539