메뉴 건너뛰기




Volumn 16, Issue 1, 2013, Pages 4-13

Belimumab: Targeted therapy for lupus

Author keywords

Autoimmune disease; B lymphocyte stimulator; Belimumab; Benlysta; Lupus; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; BELIMUMAB; PLACEBO;

EID: 84874374884     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/1756-185x.12002     Document Type: Review
Times cited : (10)

References (30)
  • 1
    • 84874382778 scopus 로고    scopus 로고
    • Centres for Disease Control and Prevention. Spotlight - Advancing our Epidemiologic Understanding of Lupus. Accessed June 15,2011.
    • Centres for Disease Control and Prevention. Spotlight - Advancing our Epidemiologic Understanding of Lupus. (http://www.cdc.gov/arthritis/resources/spotlights/advancing.htm.) Accessed June 15, 2011.
  • 2
    • 24344491492 scopus 로고    scopus 로고
    • Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices
    • Griffiths B, Mosca M, Gordon C (2005) Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol 19, 685-708.
    • (2005) Best Pract Res Clin Rheumatol , vol.19 , pp. 685-708
    • Griffiths, B.1    Mosca, M.2    Gordon, C.3
  • 3
    • 70350180430 scopus 로고    scopus 로고
    • Clinical trials for lupus - are we there yet?
    • Merrill JT (2009) Clinical trials for lupus - are we there yet? Bull NYU Hosp Jt Dis 67, 267-70.
    • (2009) Bull NYU Hosp Jt Dis , vol.67 , pp. 267-270
    • Merrill, J.T.1
  • 4
    • 74849131972 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    • Merrill JT, Neuwelt CM, Wallace DJ et al. (2010) Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 62, 222-33.
    • (2010) Arthritis Rheum , vol.62 , pp. 222-233
    • Merrill, J.T.1    Neuwelt, C.M.2    Wallace, D.J.3
  • 5
    • 75149150898 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in patients with proliferative lupus nephritis: results from the randomized, double-blind phase III LUNAR study
    • Furie RA, Looney JR, Rovin B et al. (2009) Efficacy and safety of rituximab in patients with proliferative lupus nephritis: results from the randomized, double-blind phase III LUNAR study. Arthritis Rheum 60, 429.
    • (2009) Arthritis Rheum , vol.60 , pp. 429
    • Furie, R.A.1    Looney, J.R.2    Rovin, B.3
  • 6
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
    • Navarra SV, Guzmán RM, Gallacher AE et al. (2011) Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377, 721-31.
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzmán, R.M.2    Gallacher, A.E.3
  • 7
    • 82455198794 scopus 로고    scopus 로고
    • A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus
    • Furie R, Petri M, Zamani O et al. (2011) A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. Arthritis Rheum 63, 3918-30.
    • (2011) Arthritis Rheum , vol.63 , pp. 3918-3930
    • Furie, R.1    Petri, M.2    Zamani, O.3
  • 8
    • 84862002288 scopus 로고    scopus 로고
    • Belimumab reduces autoantibodies, normalizes low complement, and reduces select B-cell populations in patients with systemic lupus erythematosus
    • Jan 24
    • Stohl W, Hiepe F, Latinis KM et al. (2012) Belimumab reduces autoantibodies, normalizes low complement, and reduces select B-cell populations in patients with systemic lupus erythematosus. Arthritis Rheum Jan 24, 2328-37.
    • (2012) Arthritis Rheum , pp. 2328-2337
    • Stohl, W.1    Hiepe, F.2    Latinis, K.M.3
  • 9
    • 84874355770 scopus 로고    scopus 로고
    • US Food and Drug Administration. FDA labelling information - Benlysta.Accessed June10, 2011
    • US Food and Drug Administration. FDA labelling information - Benlysta. (http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125370s0000lbl.pdf.) Accessed June10, 2011.
  • 10
    • 84874354626 scopus 로고    scopus 로고
    • EPAR summary for the public. European Medicines Agency; Accessed April 3, 2012. Last updated in 07-2011.
    • EPAR summary for the public. European Medicines Agency; 2011. (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/human/002015/WC500110153.pdf). Accessed April 3, 2012. Last updated in 07-2011.
    • (2011)
  • 11
    • 58549086734 scopus 로고    scopus 로고
    • The BLyS family: toward a molecular understanding of B cell homeostasis
    • Treml JF, Hao Y, Stadanlick JE, Cancro MP (2009) The BLyS family: toward a molecular understanding of B cell homeostasis. Cell Biochem Biophys 53, 1-16.
    • (2009) Cell Biochem Biophys , vol.53 , pp. 1-16
    • Treml, J.F.1    Hao, Y.2    Stadanlick, J.E.3    Cancro, M.P.4
  • 12
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore PA, Belvedere O, Orr A et al. (1999) BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285, 260-3.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3
  • 14
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
    • Cheema GS, Roschke V, Hilbert DM, Stohl W (2001) Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 44, 1313-9.
    • (2001) Arthritis Rheum , vol.44 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3    Stohl, W.4
  • 15
    • 49449092839 scopus 로고    scopus 로고
    • Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    • Petri M, Stohl W, Chatham W et al. (2008) Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum 58, 2453-9.
    • (2008) Arthritis Rheum , vol.58 , pp. 2453-2459
    • Petri, M.1    Stohl, W.2    Chatham, W.3
  • 16
    • 79953170908 scopus 로고    scopus 로고
    • Belimumab: anti-BLyS monoclonal antibody; Benlysta; BmAb; LymphoStat-B.
    • (2010) Belimumab: anti-BLyS monoclonal antibody; Benlysta; BmAb; LymphoStat-B. Drugs R D 10, 55-65.
    • (2010) Drugs R D , vol.10 , pp. 55-65
  • 17
    • 47249111687 scopus 로고    scopus 로고
    • BAFF blockade for systemic lupus erythematosus: will the promise be fulfilled?
    • Ramanujam M, Davidson A (2008) BAFF blockade for systemic lupus erythematosus: will the promise be fulfilled? Immunol Rev 223, 156-74.
    • (2008) Immunol Rev , vol.223 , pp. 156-174
    • Ramanujam, M.1    Davidson, A.2
  • 18
    • 33646827589 scopus 로고    scopus 로고
    • Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects
    • Halpern WG, Lappin P, Zanardi T et al. (2006) Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects. Toxicol Sci 1, 586-99.
    • (2006) Toxicol Sci , vol.1 , pp. 586-599
    • Halpern, W.G.1    Lappin, P.2    Zanardi, T.3
  • 19
    • 54349100000 scopus 로고    scopus 로고
    • Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus
    • Furie R, Stohl W, Ginzler EM et al. (2008) Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus. Arthritis Res Ther 10, R109.
    • (2008) Arthritis Res Ther , vol.10
    • Furie, R.1    Stohl, W.2    Ginzler, E.M.3
  • 20
    • 69749120918 scopus 로고    scopus 로고
    • A phase II, randomized, double- blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
    • Wallace DJ, Stohl W, Furie RA et al. (2009) A phase II, randomized, double- blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum 61, 1168-78.
    • (2009) Arthritis Rheum , vol.61 , pp. 1168-1178
    • Wallace, D.J.1    Stohl, W.2    Furie, R.A.3
  • 21
    • 0032752441 scopus 로고    scopus 로고
    • Classification and definition of major flares in SLE clinical trials
    • Petri M, Buyon J, Kim M (1999) Classification and definition of major flares in SLE clinical trials. Lupus 8, 685-91.
    • (1999) Lupus , vol.8 , pp. 685-691
    • Petri, M.1    Buyon, J.2    Kim, M.3
  • 22
    • 79953165936 scopus 로고    scopus 로고
    • Five-year experience with belimumab, a BLyS-specific inhibitor, in patients with Systemic Lupus Erythematosus (SLE)
    • abstract
    • Merrill JT, Wallace DJ, Furie RA et al. (2010) Five-year experience with belimumab, a BLyS-specific inhibitor, in patients with Systemic Lupus Erythematosus (SLE). [abstract] Arthritis Rheum 62(Suppl.10), 1457.
    • (2010) Arthritis Rheum , vol.62 , Issue.SUPPL.10 , pp. 1457
    • Merrill, J.T.1    Wallace, D.J.2    Furie, R.A.3
  • 23
    • 69749096135 scopus 로고    scopus 로고
    • Novel evidence-based systemic lupus erythematosus responder index
    • Furie RA, Petri MA, Wallace DJ et al. (2009) Novel evidence-based systemic lupus erythematosus responder index. Arthritis Rheum 61, 1143-51.
    • (2009) Arthritis Rheum , vol.61 , pp. 1143-1151
    • Furie, R.A.1    Petri, M.A.2    Wallace, D.J.3
  • 24
    • 84874387012 scopus 로고    scopus 로고
    • BEL114333, a Continuation Study of BEL113750 in Subjects With Systemic Lupus Erythematosus (SLE) in Northeast Asia.Accessed May 17, 2012.
    • BEL114333, a Continuation Study of BEL113750 in Subjects With Systemic Lupus Erythematosus (SLE) in Northeast Asia. (http://clinicaltrials.gov/ct2/show/NCT01597622?term=belimumab&recr=Open&no_unk=Y&rank=8) Accessed May 17, 2012.
  • 25
    • 84874374885 scopus 로고    scopus 로고
    • A 52 Week Study of Belimumab Versus Placebo in the Treatment of Subjects With Systemic Lupus Erythematosus (SLE) Located in Northeast Asia (NCT01345253).Accessed June 10, 2011.
    • A 52 Week Study of Belimumab Versus Placebo in the Treatment of Subjects With Systemic Lupus Erythematosus (SLE) Located in Northeast Asia (NCT01345253). (http://clinicaltrials.gov/ct2/show/NCT01345253?cond=%22Systemic+Lupus+Erythematosus%22&rank=17) Accessed June 10, 2011.
  • 26
    • 84874371527 scopus 로고    scopus 로고
    • A Study of Belimumab Administered Subcutaneously in Subjects With Systemic Lupus Erythematosus (SLE) (BLISS-SC).Accessed May 17, 2012.
    • A Study of Belimumab Administered Subcutaneously in Subjects With Systemic Lupus Erythematosus (SLE) (BLISS-SC).(http://clinicaltrials.gov/ct2/show/NCT01484496?term=belimumab&recr=Open&no_unk=Y&rank=3) Accessed May 17, 2012.
  • 27
    • 84874379435 scopus 로고    scopus 로고
    • A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE).Accessed May 17, 2012.
    • A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE). (http://clinicaltrials.gov/ct2/show/NCT01597492?term=belimumab&rank=10) Accessed May 17, 2012.
  • 28
    • 84874375835 scopus 로고    scopus 로고
    • Benlysta Pregnancy Registry.Accessed May 17, 2012.
    • Benlysta Pregnancy Registry. (http://clinicaltrials.gov/ct2/show/NCT01532310?term=belimumab&recr=Open&no_unk=Y&rank=4). Accessed May 17, 2012.
  • 29
    • 84874350064 scopus 로고    scopus 로고
    • Clinicaltrials.gov, A service of the U.S. National Institutes of Health.Accessed June 1, 2012.
    • Clinicaltrials.gov, A service of the U.S. National Institutes of Health. (http://clinicaltrials.gov/ct2/results?term=belimumab) Accessed June 1, 2012.
  • 30
    • 84858751079 scopus 로고    scopus 로고
    • Lupus: novel therapies in clinical development
    • Chugh PK (2012) Lupus: novel therapies in clinical development. Eur J Intern Med 23, 212-8.
    • (2012) Eur J Intern Med , vol.23 , pp. 212-218
    • Chugh, P.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.