Genome-wide association study on plasma levels of midregional- proadrenomedullin and C-terminal-pro-endothelin-1

Hypertension

Volumn 61, Issue 3, 2013, Pages 602-608

  Verweij, Niek ^a   Mahmud, Hasan ^a   Leach, Irene Mateo ^a   De Boer, Rudolf A ^a   Brouwers, Frank P ^a   Yu, Hongjuan ^a   Asselbergs, Folkert W ^b   Struck, Joachim ^c   Bakker, Stephan J L ^a,d   Gansevoort, Ron T ^a   Munroe, Patricia B ^e   Hillege, Hans L ^a   Van Veldhuisen, Dirk J ^a   Van Gilst, Wiek H ^a   Silljé, Herman H W ^a   Van Der Harst, Pim ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c THERMO FISHER SCIENTIFIC   (Germany)

^d TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

adrenomedullin; blood pressure; cardiovascular; endothelin 1; genome wide association study; kallikrein

Indexed keywords

BRADYKININ; C TERMINAL PRO ENDOTHELIN 1; ENDOTHELIN 1; HIGH MOLECULAR WEIGHT KININOGEN; PLASMA KALLIKREIN; PROADRENOMEDULLIN; PRORENIN; RENIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; EPISTASIS; FOLLOW UP; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IN VITRO STUDY; KALLIKREIN KININ SYSTEM; META ANALYSIS (TOPIC); PHENOTYPIC VARIATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADRENOMEDULLIN; ADULT; AGED; ENDOTHELIN-1; EPISTASIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; KALLIKREIN-KININ SYSTEM; KALLIKREINS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN PRECURSORS;

EID: 84874373995     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.203117     Document Type: Article

References (31)

1. Kohan DE, Rossi NF, Inscho EW, Pollock DM. Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev. 2011;91:1-77.
2. Samson WK. Adrenomedullin and the control of fluid and electrolyte homeostasis. Annu Rev Physiol. 1999;61:363-389.
3. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem. 2005;51:1823-1829.
4. Papassotiriou J, Morgenthaler NG, Struck J, Alonso C, Bergmann A. Immunoluminometric assay for measurement of the C-terminal endothelin-1 precursor fragment in human plasma. Clin Chem. 2006;52:1144-1151.
5. Dhillon OS, Khan SQ, Narayan HK, Ng KH, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL. Prognostic value of mid-regional pro-adrenomedullin levels taken on admission and discharge in non-ST-elevation myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) II study. J Am Coll Cardiol. 2010;56:125-133.
6. Jankowska EA, Filippatos GS, von Haehling S, et al. Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1. PLoS ONE. 2011;6:e14506.
7. von Haehling S, Filippatos GS, Papassotiriou J, Cicoira M, Jankowska EA, Doehner W, Rozentryt P, Vassanelli C, Struck J, Banasiak W, Ponikowski P, Kremastinos D, Bergmann A, Morgenthaler NG, Anker SD. Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with chronic heart failure. Eur J Heart Fail. 2010;12:484-491.
8. Maisel A, Mueller C, Nowak RM, et al. Midregion prohormone adrenomedullin and prognosis in patients presenting with acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol. 2011;58:1057-1067.
9. Schnabel RB, Wild PS, Schulz A, Zeller T, Sinning CR, Wilde S, Kunde J, Lubos E, Lackner KJ, Warnholtz A, Gori T, Blankenberg S, Munzel T; Gutenberg Health Study Investigators. Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study. Hypertension. 2012;60:288-295.
10. Hillege HL, Fidler V, Diercks GF, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, Gans RO, Janssen WM, Grobbee DE, de Jong PE; Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation. 2002;106:1777-1782.
11. Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ; International Schizophrenia Consortium. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 2009;5:e1000534.
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559-575.
13. Gallimore MJ, Fareid E, Stormorken H. The purification of a human plasma kallikrein with weak plasminogen activator activity. Thromb Res. 1978;12:409-420.
14. Hayashi J, Salomon DR, Hugli TE. Elevated kallikrein activity in plasma from stable liver transplant recipients. Int Immunopharmacol. 2002;2:1667-1680.
15. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26:2190-2191.
16. Shariat-Madar Z, Mahdi F, Schmaier AH. Assembly and activation of the plasma kallikrein/kinin system: a new interpretation. Int Immunopharmacol. 2002;2:1841-1849.
17. Inoue A, Yanagisawa M, Takuwa Y, Mitsui Y, Kobayashi M, Masaki T. The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J Biol Chem. 1989;264:14954-14959.
18. Metters KM, Rossier J, Paquin J, Chrétien M, Seidah NG. Selective cleavage of proenkephalin-derived peptides (less than 23,300 daltons) by plasma kallikrein. J Biol Chem. 1988;263:12543-12553.
19. Suhre K, Shin SY, Petersen AK, et al; CARDIoGRAM. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2011;477:54-60.
20. Abstract P244: Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association with the Kininogen 1 and Prekallikrein Genes. American Heart Association, Atlanta, GA. 2011 Mar 22-25.
21. Katsuda I, Maruyama F, Ezaki K, Sawamura T, Ichihara Y. A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region. Eur J Haematol. 2007;79:59-68.
22. Schmaier AH. The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1-13.
23. Shen B, El-Dahr SS. Cross-talk of the renin-angiotensin and kallikreinkinin systems. Biol Chem. 2006;387:145-150.
24. Vogt S, Winkler E, Hermsen D, Schott M, Schinner S, Scherbaum WA, Willenberg HS. Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone. Clin Exp Hypertens. 2012;34:582-587.
25. Yayama K, Kunimatsu N, Teranishi Y, Takano M, Okamoto H. Tissue kallikrein is synthesized and secreted by human vascular endothelial cells. Biochim Biophys Acta. 2003;1593:231-238.
26. Lipke DW, Olson KR. A specific inhibitor of mammalian kallikrein, Phe-Phe-Arg-chloromethyl ketone, inhibits the production of vasoactive substances from trout plasma by kallikrein and blocks endogenous kallikrein-like activity in trout gills. Fish Physiol Biochem. 1992;10:339-346.
27. Cheung BM, Ong KL, Tso AW, Leung RY, Cherny SS, Sham PC, Lam TH, Lam KS; Investigators of Hong Kong Cardiovascular Risk Factor Prevalence Study. Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene. Eur J Endocrinol. 2011;165:571-577.
28. Ehret GB, Munroe PB, Rice KM, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-109.
29. Vadapalli S, Rani HS, Sastry B, Nallari P. Endothelin-1 and endothelial nitric oxide polymorphisms in idiopathic pulmonary arterial hypertension. Int J Mol Epidemiol Genet. 2010;1:208-213.
30. Rankinen T, Church T, Rice T, Markward N, Leon AS, Rao DC, Skinner JS, Blair SN, Bouchard C. Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levels. Hypertension. 2007;50:1120-1125.
31. Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nat Med. 2011;17:206-210.