A clinical phase in trial of ulinastatin (MR-20) for nephrotoxicity of cisplatin

Japanese Journal of Cancer and Chemotherapy

Volumn 25, Issue 1, 1998, Pages 97-109

  Nishikawa, Hideki ^a   Nakabayashi, Takehito ^b   Nakai, Yushi ^c   Kurita, Yuzo ^d   Fukuoka, Masahiro ^e   Onoshi, Taisuke ^f   Ogura, Tsuyoshi ^a   Sakuma, Akira ^g   Niitani, Hisanobu ^h   Tsubura, Eiro ⁱ  

^a TONEYAMA NATIONAL HOSPITAL   (Japan)

^b HOKKAIDO CANCER CENTER   (Japan)

^c SENDAI KOUSEI HOSPITAL   (Japan)

^d NIIGATA CANCER CENTER HOSPITAL   (Japan)

^e OSAKA CITY GENERAL HOSPITAL   (Japan)

^f OKAYAMA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^h Jizankai Medical Research Institute   (Japan)

ⁱ Osaka Hospital   (Japan)

Author keywords

Lung cancer; Nephrotoxicity of cisplatin; Ulinastatin

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CREATININE; GLYCOPROTEIN; TRYPSIN INHIBITOR; ULINASTATIN;

ADULT; AGED; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG ADMINISTRATION; DRUG EFFECT; FEMALE; HUMAN; KIDNEY; KIDNEY DISEASE; LUNG TUMOR; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL; UREA NITROGEN BLOOD LEVEL;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BLOOD UREA NITROGEN; CISPLATIN; CREATININE; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLYCOPROTEINS; HUMANS; KIDNEY; KIDNEY DISEASES; LUNG NEOPLASMS; MALE; MIDDLE AGED; TRYPSIN INHIBITORS;

EID: 84874320278     PISSN: 03850684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Yamasaki, F., Ishibashi, M., Nakakuki, M. et al: Protective action of ulinastatin against cisplatin nephrotoxicity in mice and its effect on the lysosomal fragility . Nephron 74 : 158-167, 1996.
2. Nakakuki, M., Yamasaki, F., Shinkawa, T, et al: Protective effect of human ulinastatin against gentami-cin - induced acute renal failure in rats. Can. J. Physiol. Pharmacol. 74:104-111, 1996.
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4. Dobyan, D. C., Levi, J., Jacobs, C. et al: Mechanism of cis-Platinum Nephrotoxicity : II. Morphologic Observations. J. Pharmacol Exp. Ther. 213(3) : 551-556, 1980.
5. Kobayashi, H., Ohi, H. and Terao, T. : Prevention by Ulinastatin of Cis-Diammine-dichloroplatinum-Induced Nephrotoxicity in Rabbits : Comparison of Urinary Enzyme Excretions and Morphological Alterations by Electron Microscopy. Asia-Oceania J. Obstet. Gynecol. 17 : 277-288, 1991.
6. Yamasaki, F., Shinkawa, T., Watanabe, M. et al: Uptake of human urinary trypsin inhibitor by the kidney epithelial cell line, LLC-PK,. Pflugers Archiv. 433 : 9-15, 1996.