GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication

Circulation Research

Volumn 112, Issue 4, 2013, Pages 633-639

  Kuster, Diederik W D ^a   Sequeira, Vasco ^a   Najafi, Aref ^a   Boontje, Nicky M ^a   Wijnker, Paul J M ^a   Rosalie Witjas Paalberends, E ^a   Marston, Steven B ^b   Dos Remedios, Cristobal G ^c   Carrier, Lucie ^d,e   Demmers, Jeroen A A ^f   Redwood, Charles ^g   Sadayappan, Sakthivel ^h   Van Der Velden, Jolanda ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e Sorbonne Université   (France)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

cardiac myosin binding protein C; contractile proteins; GSK3 ; heart failure; hypertrophy remodeling; myocardial contractility; phosphorylation

Indexed keywords

ALANINE; CARDIAC MYOSIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; MYOSIN BINDING PROTEIN C; PROLINE; SERINE;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN TARGETING; SARCOMERE; TANDEM MASS SPECTROMETRY;

EID: 84874271634     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.275602     Document Type: Article

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