Influence of co-monomer ratio on the chemical properties and cytotoxicity of poly[acrylonitrile-co-(N-vinylpyrrolidone)] nanoparticles

Journal of Applied Biomaterials and Functional Materials

Volumn 10, Issue 3, 2012, Pages 308-314

  Li, Wenzhong ^a   Pierce, Benjamin Franklin ^a   Scharnagl, Nico ^a   Wischke, Christian ^a   Sisson, Adam Lee ^a   Lendlein, Andreas ^a  

^a INSTITUTE OF MATERIALS RESEARCH   (Germany)

Author keywords

Biocompatibility; Biomaterials; Mini emulsion; Nanoparticles

Indexed keywords

CELL CULTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY; EMULSIFICATION; ENCAPSULATION; FIBROBLASTS; GLASS TRANSITION; HYDROPHILICITY; LIGHT SCATTERING; NANOPARTICLES; SYNTHESIS (CHEMICAL); THERMOGRAVIMETRIC ANALYSIS;

CELLULAR UPTAKE; COMONOMERS; DRUG ENCAPSULATION; L929 FIBROBLASTS; MINI EMULSION; MODELLING SYSTEMS; MONOMERS RATIO; N VINYLPYRROLIDONE; POLY(ACRYLONITRILE); UPTAKE PROPERTIES;

BIOCOMPATIBILITY;

1 VINYL 2 PYRROLIDINONE; ACRYLONITRILE; BIOMATERIAL; NANOPARTICLE; POLY[ACRYLONITRILE CO (N VINYLPYRROLIDONE)] NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DIFFERENTIAL SCANNING CALORIMETRY; EMULSION; FIBROBLAST; GLASS TRANSITION TEMPERATURE; HYDROPHILICITY; LIGHT SCATTERING; MOLECULAR SIZE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; THERMOGRAVIMETRY;

EID: 84874262877     PISSN: None     EISSN: 22808000     Source Type: Journal    
DOI: 10.5301/JABFM.2012.10430     Document Type: Article

References (22)

1. Lorenz S, Hauser CP, Autenrieth B, Weiss CK, Landfester K, Mailänder V. The softer and more hydrophobic the better: influence of the side chain of polymethacrylate nanoparticles for cellular uptake. Macromol Biosci 2010; 10: 1034-42.
2. Tanzi MC, Bozzini S, Candiani G, et al. Trends in biomedical engineering: focus on smart bio-materials and drug delivery. J Appl Biomater Biomech 2011; 9: 87-97.
3. Boese G, Trimpert C, Albrecht W, Malsch G, Groth T, Lendlein A. Membranes from acrylonitrile-based polymers for selective cultivation of human keratinocytes. J Tissue Eng 2007; 13: 2995-3002.
4. Wan L-S, Xu Z-K, Huang X-J, Wang Z-G, Ye P. Hemocompatibility of poly(acrylonitrile-co-N-vinyl-2-pyrrolidone)s: swelling behaviour and water states. Macromol Biosci 2005; 5: 229-36.
5. Wan L-S, Xu Z-K, Huang X-J, Huang X-D, Yao K. Cytocompatibility of poly(acrylonitrile-co-N-vinyl-2-pyrrolidone) membranes with human endothelial cells and macrophages. Acta Biomater 2007; 3: 183-90.
6. Krasteva N, Harms U, Albrecht W, et al. Membranes for biohybrid liver support systems - investigations on hepatocyte attachment, morphology and growth. Biomaterials 2002; 23: 2467-78.
7. Wan L-S, Xu Z-K, Huang X-J. Asymmetric membranes fabricated from poly(acrylonitrile-co-N-vinyl-2-pyrrolidone)s with excellent biocompatibility. J Appl Polym Sci 2006; 102: 4577-83.
8. Wan L-S, Xu Z-K, Jiang H-L. Fibrous membranes electrospinning from acrylonitrile-based polymers: specific absorption behaviors and states of water. Macromol Biosci 2006; 6: 364-72.
9. Wan L-S, Xu Z-K, Huang X-J, Wang Z-G, Wang J-L. Copolymerization of acrylonitrile with N-vinyl-2-pyrrolidone to improve the hemocompatibility of polyacrylonitrile. Polymer 2005; 46: 7715-23.
10. Landfester K, Antonietti M. The polymerization of acrylonitrile in miniemulsions: 'crumpled latex particles' or polymer nanocrystals. Macromol Rapid Commun 2000; 21: 820-4.
11. Boguslavsky L, Baruch S, Margel S. Synthesis and characterization of polyacrylonitrile nanoparticles by dispersion/ emulsion polymerization process. J Colloid Interface Sci2005; 289: 71-85.
12. Blythe PJ, Klein A, Phillips A, Sudol ED, El-Aaser MS. Miniemulsion polymerization of styrene using the oil-soluble initiator AMBN. J Polym Sci A Polym Chem 1999; 37: 4449-57.
13. Alduncin JA, Forcada J, Barandiaran MJ, Asua JM. On the main locus of radical formation in emulsion polymerization initiated by oil-soluble initiators. J Polym Sci A Polym Chem 1991; 29, 1265-70.
14. Jeon HJ, You Y, Yoon MJ, Youk JH. Preparation of polyacrylonitrile nanoparticles via dispersion polymerization of acrylonitrile using a poly(N-vinyl pyrrolidone)-cobalt complex in an aqueous system. Polymer 2011; 52: 3905-11.
15. Debuigne A, Caille J-R, Jerome R. Synthesis of end-functionalized poly(vinyl acetate) by cobalt-mediated radical polymerization. Macromolecules 2005; 38: 5452-8.
16. Hou C, Wang C-G, Cai H-S, Zhang, W-X. Determination of the reactivity ratios for acrylonitrile/N-vinylpyrrolidone copolymerization systems. J Appl Polym Sci 2003; 89: 422-5.
17. Hou C, Sun C-F, Ying L, Wang C-G. Monte carlo simulations of sequence distributions of acrylonitrile copolymers. J Appl Polym Sci 2005; 96: 483-88.
18. Fox TG. Influence of diluent and of copolymer composition on the glass temperature of a polymer system. Bull Am Phys Soc 1956; 1: 123.
19. Feldstein MM, Kuptsov SA, Shandryuk GA. Coherence of thermal transitions in poly(N-vinyl pyrrolidone) - poly(ethylene glycol) compatible blends 2. The temperature of maximum cold crystallization rate versus glass transition. Polymer 2000; 41: 5339-48.
20. Gudiksen KL, Gitlin I, Whitesides GM. Differentiation of proteins based on characteristic patterns of association and denaturation in solutions of SDS. Proc Natl Acad Sci USA 2006; 103: 7968-72.
21. Delgado J, El-Aasser MS, Vanderhoff JW. Miniemulsion copolymerization of vinyl acetate and butyl acrylate. I. Differences between the miniemulsion copolymerization and the emulsion copolymerization processes. J Polym Sci A Polym Chem 1986; 24: 861-74.
22. Alduncin JA, Forcada J, Asua JM. Miniemulsion polymerization using oil-soluble initiators. Macromolecules 1994; 27: 2256-61.