Two days of antithymocyte globulin are associated with a reduced incidence of acute and chronic graft-versus-host disease in reduced-intensity conditioning transplantation for hematologic diseases

Cancer

Volumn 119, Issue 5, 2013, Pages 986-992

  Crocchiolo, Roberto ^a   Esterni, Benjamin ^a   Castagna, Luca ^a   Fürst, Sabine ^a   El Cheikh, Jean ^a   Devillier, Raynier ^a   Granata, Angela ^a   Oudin, Claire ^a   Calmels, Boris ^a   Chabannon, Christian ^a,b,c   Bouabdallah, Réda ^a   Vey, Norbert ^a,c   Blaise, Didier ^a,b,c  

^a INSTITUT PAOLI CALMETTES   (France)

^b INSERM   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

Author keywords

allogeneic stem cell transplantation; antithymocyte globulin; graft versus host disease; reduced intensity conditioning; relapse

Indexed keywords

BUSULFAN; FLUDARABINE; FLUDARABINE PHOSPHATE; GENZYME; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; AGED; ARTICLE; CHRONIC GRAFT VERSUS HOST DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HEMATOLOGIC DISEASE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OVERALL SURVIVAL; PRIORITY JOURNAL; RECURRENCE RISK; REDUCED INTENSITY CONDITIONING; RELAPSE; RETROSPECTIVE STUDY; UNRELATED DONORS;

ADOLESCENT; ADULT; AGED; ANTILYMPHOCYTE SERUM; BUSULFAN; DRUG ADMINISTRATION SCHEDULE; FEMALE; GRAFT VS HOST REACTION; HEMATOLOGIC DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; TRANSPLANTATION CONDITIONING; VIDARABINE; YOUNG ADULT;

EID: 84874254559     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27858     Document Type: Article

References (35)

1. Slavin S, Nagler A, Naparstek E, et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood. 1998; 91: 756-763.
2. Sureda A, Robinson S, Canals C, et al. Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma: an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2008; 26: 455-462.
3. Georges GE, Storb R,. Review of "minitransplantation": nonmyeloablative allogeneic hematopoietic stem cell transplantation. Int J Hematol. 2003; 77: 3-14.
4. Mohty M, Bay JO, Faucher C, et al. Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin-based reduced-intensity preparative regimen. Blood. 2003; 102: 470-476.
5. Malard F, Cahu X, Clavert A, et al. Fludarabine, antithymocyte globulin, and very low-dose busulfan for reduced-intensity conditioning before allogeneic stem cell transplantation in patients with lymphoid malignancies. Biol Blood Marrow Transplant. 2011; 17: 1698-1703.
6. Schetelig J, Thiede C, Bornhauser M, et al. Cooperative German Transplant Study Group. Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group. J Clin Oncol. 2003; 21: 2747-2753.
7. Finke J, Bethge WA, Schmoor C, et al. ATG-Fresenius Trial Group. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncol. 2009; 10: 855-864.
8. Bacigalupo A, Lamparelli T, Barisione G, et al. Gruppo Italiano Trapianti Midollo Osseo (GITMO). Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation. Biol Blood Marrow Transplant. 2006; 12: 560-565.
9. Bacigalupo A, Lamparelli T, Bruzzi P, et al. Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood. 2001; 98: 2942-2947.
10. Maraninchi D, Gluckman E, Blaise D, et al. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias. Lancet. 1987; 25: 175-178.
11. Goldman JM, Gale RP, Horowitz MM, et al. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann Intern Med. 1988; 108: 806-814.
12. Apperley JF, Jones L, Hale G, et al. Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse. Bone Marrow Transplant. 1986; 1: 53-66.
13. Bacigalupo A,. Antithymocyte globulin for prevention of graft-versus-host disease. Curr Opin Hematol. 2005; 12: 457-462.
14. Mohty M,. Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond. Leukemia. 2007; 21: 1387-1394.
15. Blaise D, Farnault L, C Faucher C, et al. Reduced intensity conditioning with fludarabine, oral busulfan and thymoglobulin allows long term disease control and low transplant related mortality in patients with haematological malignancies. Exp Hematol. 2010; 38: 1241-1250.
16. Duggan P, Booth K, Chaudhry A, et al. Alberta Blood and Bone Marrow Transplant Program. Unrelated donor BMT recipients given pretransplant low-dose antithymocyte globulin have outcomes equivalent to matched sibling BMT: a matched pair analysis. Bone Marrow Transplant. 2002; 30: 681-686.
17. Russell JA, Irish W, Balogh A, et al. The addition of 400 cGY total body irradiation to a regimen incorporating once-daily intravenous busulfan, fludarabine, and antithymocyte globulin reduces relapse without affecting nonrelapse mortality in acute myelogenous leukemia. Biol Blood Marrow Transplant. 2010; 16: 509-514.
18. Kahl C, Storer BE, Sandmaier BM, et al. Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. Blood. 2007; 110: 2744-2748.
19. Kaplan EL, Meier P,. Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958; 53: 457-481.
20. Cox D,. Regression models and life tables. J R Stat Soc (B). 1972; 34: 187-220.
21. Gooley TA, Leisenring W, Crowley J, Storer BE,. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999; 18: 695-706.
22. Fine JP, Gray RJ,. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999; 94: 496-509.
23. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients from HL-A-matched sibling donors. Transplantation. 1974; 18: 295-304.
24. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980; 69: 204-217.
25. El Kourashy S, Williamson T, Chaudhry MA, et al. Influence of comorbidities on transplant outcomes in patients aged 50 years or more after myeloablative conditioning incorporating fludarabine, BU and ATG. Bone Marrow Transplant. 2011; 46: 1077-1083.
26. Hamadani M, Blum W, Phillips G, et al. Improved nonrelapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced-intensity conditioning allogeneic transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2009; 15: 1422-1430.
27. Hamadani M, Craig M, Phillips GS, et al. Higher busulfan dose intensity does not improve outcomes of patients undergoing allogeneic haematopoietic cell transplantation following fludarabine, busulfan-based reduced toxicity conditioning. Hematol Oncol. 2011; 29: 202-210.
28. Bashir Q, Munsell M, Giralt S, et al. Randomized phase II trial comparing 2 dose levels of thymoglobulin in patients undergoing donor hematopoietic cell transplant. Leuk Lymphoma. 2012; 53: 915-919.
29. Soiffier R, LeRademacher J, Ho V, et al. Impact of immune modulation with anti-T-cell antibodies on the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematological malignancies. Blood. 2011; 117: 6963-6970.
30. Socie G, Schmoor C, Bethge WA, et al. ATG-Fresenius Trial Group. Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius. Blood. 2011; 117: 6375-6382.
31. Mohty M, Labopin M, Balere ML, et al. Antithymocyte globulins and chronic graft-vs-host disease after myeloablative allogeneic stem cell transplantation from HLA-matched unrelated donors: a report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. Leukemia. 2010; 24: 1867-1874.
32. Andersson BS, de Lima M, Thall PF, Madden T, Russell JA, Champlin RE,. Reduced-toxicity conditioning therapy with allogeneic stem cell transplantation for acute leukemia. Curr Opin Oncol. 2009; 21 (1 suppl): S11-S15.
33. de Lima M, Giralt S, Thall PF, et al. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study. Cancer. 2010; 116: 5420-5431.
34. Kroger N, Zabelina T, Klyuchnikov E, et al. Toxicity-reduced, myeloablative allograft followed by lenalidomide maintenance as salvage therapy for refractory/relapsed myeloma patients [published online ahead of print August 6, 2012]. Bone Marrow Transplant. 2012.
35. El-Cheikh J, Crocchiolo R, Furst S, et al. Lenalidomide plus donor-lymphocytes infusion after allogeneic stem-cell transplantation with reduced-intensity conditioning in patients with high-risk multiple myeloma. Exp Hematol. 2012; 40: 521-527.