A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes

Molecular Cell

Volumn 49, Issue 4, 2013, Pages 704-718

  Nair, Sujit S ^a   Li, Da Qiang ^a   Kumar, Rakesh ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COREPRESSOR PROTEIN; HISTONE DEACETYLASE; LYSINE; METASTATIC TUMOR ANTIGEN 1; METHYLTRANSFERASE; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; DEMETHYLATION; EPIGENETICS; GENE AMPLIFICATION; HISTONE MODIFICATION; METHYLATION; NUCLEOSOME; SIGNAL TRANSDUCTION;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; CERCOPITHECUS AETHIOPS; CHROMATIN ASSEMBLY AND DISASSEMBLY; COS CELLS; EPIGENESIS, GENETIC; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS; HISTONE DEACETYLASES; HISTONE DEMETHYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; METHYLATION; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; MICE; MOLECULAR SEQUENCE DATA; NUCLEOSOMES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 84874234092     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.12.016     Document Type: Article

References (20)

1. Balasenthil S., Gururaj A.E., Talukder A.H., Bagheri-Yarmand R., Arrington T., Haas B.J., Braisted J.C., Kim I., Lee N.H., Kumar R. Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res. 2007, 67:7132-7138.
2. Collins R.E., Northrop J.P., Horton J.R., Lee D.Y., Zhang X., Stallcup M.R., Cheng X. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat. Struct. Mol. Biol. 2008, 15:245-250.
3. Ghanta K.S., Li D.Q., Eswaran J., Kumar R. Gene profiling of MTA1 identifies novel gene targets and functions. PLoS ONE 2011, 6:e17135.
4. Lai A.Y., Wade P.A. Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat. Rev. Cancer 2011, 11:588-596.
5. Lan F., Collins R.E., De Cegli R., Alpatov R., Horton J.R., Shi X., Gozani O., Cheng X., Shi Y. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature 2007, 448:718-722.
6. Lehner B., Crombie C., Tischler J., Fortunato A., Fraser A.G. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat. Genet. 2006, 38:896-903.
7. Li D.Q., Pakala S.B., Reddy S.D., Ohshiro K., Peng S.H., Lian Y., Fu S.W., Kumar R. Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J. Biol. Chem. 2010, 285:10044-10052.
8. Li D.Q., Pakala S.B., Nair S.S., Eswaran J., Kumar R. Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer. Cancer Res. 2012, 72:387-394.
9. Manavathi B., Kumar R. Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J. Biol. Chem. 2007, 282:1529-1533.
10. Metzger E., Wissmann M., Yin N., Müller J.M., Schneider R., Peters A.H., Günther T., Buettner R., Schüle R. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005, 437:436-439.
11. Nair S.S., Nair B.C., Cortez V., Chakravarty D., Metzger E., Schüle R., Brann D.W., Tekmal R.R., Vadlamudi R.K. PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO Rep. 2010, 11:438-444.
12. Nishioka K., Chuikov S., Sarma K., Erdjument-Bromage H., Allis C.D., Tempst P., Reinberg D. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 2002, 16:479-489.
13. Perissi V., Jepsen K., Glass C.K., Rosenfeld M.G. Deconstructing repression: evolving models of co-repressor action. Nat. Rev. Genet. 2010, 11:109-123.
14. Rathert P., Dhayalan A., Murakami M., Zhang X., Tamas R., Jurkowska R., Komatsu Y., Shinkai Y., Cheng X., Jeltsch A. Protein lysine methyltransferase G9a acts on non-histone targets. Nat. Chem. Biol. 2008, 4:344-346.
15. Shi Y., Lan F., Matson C., Mulligan P., Whetstine J.R., Cole P.A., Casero R.A., Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004, 119:941-953.
16. Tong J.K., Hassig C.A., Schnitzler G.R., Kingston R.E., Schreiber S.L. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 1998, 395:917-921.
17. Wang L., Charroux B., Kerridge S., Tsai C.C. Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep. 2008, 9:555-562.
18. Wysocka J. Identifying novel proteins recognizing histone modifications using peptide pull-down assay. Methods 2006, 40:339-343.
19. Xue Y., Wong J., Moreno G.T., Young M.K., Côté J., Wang W. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol. Cell 1998, 2:851-861.
20. Zegerman P., Canas B., Pappin D., Kouzarides T. Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J. Biol. Chem. 2002, 277:11621-11624.