Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity

Journal of Neuroscience

Volumn 33, Issue 8, 2013, Pages 3582-3587

  Chen, Yong ^a   Khan, Reas S ^a   Cwanger, Alyssa ^a   Song, Ying ^a   Steenstra, Catherine ^a   Bang, Sookhee ^a   Cheah, Jaime H ^b,c   Dunaief, Joshua ^a   Shindler, Kenneth S ^a   Snyder, Solomon H ^b   Kim, Sangwon F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NITRIC OXIDE; PROTEIN DEXRAS 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL COUNT; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; EXCITOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IRON TRANSPORT; MOUSE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CEREBRAL CORTEX; GLUTAMIC ACID; HEK293 CELLS; HUMANS; IRON; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOMERIC GTP-BINDING PROTEINS; N-METHYLASPARTATE; NITRIC OXIDE; PC12 CELLS; RAS PROTEINS; RATS; RETINAL GANGLION CELLS;

EID: 84874218109     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1497-12.2013     Document Type: Article

References (31)

1. Blumer JB, Cismowski MJ, Sato M, Lanier SM (2005) AGS proteins: receptor-independent activators of G-protein signaling. Trends Pharmacol Sci 26:470-476. CrossRef Medline
2. Cheah JH, Kim SF, Hester LD, Clancy KW, Patterson SE 3rd, Papadopoulos V, Snyder SH (2006) NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron 51:431-440. CrossRef Medline
3. Cheng HY, Obrietan K, Cain SW, Lee BY, Agostino PV, Joza NA, Harrington ME, Ralph MR, Penninger JM (2004) Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 43:715-728. CrossRef Medline
4. Cismowski MJ, Ma C, Ribas C, Xie X, Spruyt M, Lizano JS, Lanier SM, Duzic E (2000) Activation of heterotrimeric G-protein signaling by a rasrelated protein: implications for signal integration. J Biol Chem 275: 23421-23424. CrossRef Medline
5. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A 88:6368-6371. CrossRef Medline
6. Dexter DT, Carayon A, Javoy-Agid F, Agid Y, Wells FR, Daniel SE, Lees AJ, Jenner P, Marsden CD (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114:1953-1975. CrossRef Medline
7. Dreyer EB (1998) A proposed role for excitotoxicity in glaucoma. J Glaucoma 7:62-67. Medline
8. Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (1999) Rhes: a striatal-specific Ras homolog related to Dexras1. J Neurosci Res 57:782-788. CrossRef Medline
9. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH (2000) Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28:183-193. CrossRef Medline
10. Foster MW, Hess DT, Stamler JS (2009) Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 15:391-404. CrossRef Medline
11. Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Grieco S, Lee J, Lyubarsky A, Pratico D, Connelly J, Spino M, Harris ZL, Dunaief JL (2011) The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. Invest Ophthalmol Vis Sci 52:959-968 CrossRef Medline
12. Hara MR, Snyder SH (2007) Cell signaling and neuronal death. Annu Rev Pharmacol Toxicol 47:117-141. CrossRef Medline
13. Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (1998) CA-PON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 20:115-124. CrossRef Medline
14. Kemppainen RJ, Behrend EN (1998) Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem 273:3129-3131 CrossRef Medline
15. Kim SF, Huri DA, Snyder SH (2005) Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310:1966-1970 CrossRef Medline
16. Koh JY, Choi DW (1988) Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci 8:2153-2163. Medline
17. Lau KF, Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM, Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. J Biol Chem 283:34728-34737. CrossRef Medline
18. Liang FQ, Anand V, Maguire AM, Bennett J (2001) Intraocular delivery of recombinant virus. Methods Mol Med 47:125-139. CrossRef Medline
19. McCord JM (1998) Iron, free radicals, and oxidative injury. Semin Hematol 35:5-12. Medline
20. Nguyen CH, Watts VJ (2005) Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1. Biochem Biophys Res Commun 332:913-920. CrossRef Medline
21. Nguyen D, Alavi MV, Kim KY, Kang T, Scott RT, Noh YH, Lindsey JD, Wissinger B, Ellisman MH, Weinreb RN, Perkins GA, Ju WK (2011) A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. Cell Death Dis 2:e240. CrossRef Medline
22. Pitt D, Werner P, Raine CS (2000) Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 6:67-70. CrossRef Medline
23. Quinn TA, Dutt M, Shindler KS (2011) Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis. Front Neurol 2:50. CrossRef Medline
24. Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, Duyckaerts C, Sazdovitch V, Zhao L, Garrick LM, Nuñez MT, Garrick MD, Raisman-Vozari R, Hirsch EC (2008) Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A 105:18578-18583 CrossRef Medline
25. Shindler KS, Guan Y, Ventura E, Bennett J, Rostami A (2006) Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis. Mult Scler 12:526-532. CrossRef Medline
26. Shindler KS, Ventura E, Dutt M, Rostami A (2008) Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Exp Eye Res 87:208-213. CrossRef Medline
27. Snyder AM, Connor JR (2009) Iron, the substantia nigra and related neurological disorders. Biochim Biophys Acta 1790:606-614. CrossRef Medline
28. Subramaniam S, Sixt KM, Barrow R, Snyder SH (2009) Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science 324:1327-1330. CrossRef Medline
29. Sucher NJ, Lipton SA, Dreyer EB (1997) Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res 37:3483-3493. CrossRef Medline
30. Thomas M, Jankovic J (2004) Neurodegenerative disease and iron storage in the brain. Curr Opin Neurol 17:437-442. CrossRef Medline
31. Vargiu P, Morte B, Manzano J, Perez J, de Abajo R, Gregor Sutcliffe J, Bernal J (2001) Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum. Brain Res Mol Brain Res 94:1-8. CrossRef Medline