Defying the stereotype: Non-canonical roles of the peptide hormones guanylin and uroguanylin

Frontiers in Endocrinology

Volumn 2, Issue JUN, 2010, Pages

  Basu, Nirmalya ^a   Visweswariah, Sandhya Srikant ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

GC C; GC D; Guanylin; Receptor guanylyl cyclase; Uroguanylin

Indexed keywords

EID: 84874201626     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2011.00014     Document Type: Article

References (34)

1. Basu, N., Arshad, N., and Visweswariah, S. S. (2010). Receptor guanylyl cyclase C (GC-C): regulation and signal transduction. Mol. Cell. Biochem. 334, 67-80.
2. Basu, N., Bhandari, R., Natarajan, V. T., and Visweswariah, S. S. (2009). Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis. Mol. Cell. Biol. 29, 5277-5289.
3. Buxton, I. L., Milton, D., Barnett, S. D., and Tichenor, S. D. (2010). Agonist- specific compartmentation of cGMP action in myometrium. J. Pharmacol. Exp. Ther. 335, 256-263.
4. Carrithers, S. L., Barber, M. T., Biswas, S., Parkinson, S. J., Park, P. K., Goldstein, S. D., and Waldman, S. A. (1996). Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues. Proc. Natl. Acad. Sci. U.S.A. 93, 14827-14832.
5. Carrithers, S. L., Ott, C. E., Hill, M. J., Johnson, B. R., Cai, W., Chang, J. J., Shah, R. G., Sun, C., Mann, E. A., Fonteles, M. C., Forte, L. R., Jackson, B. A., Giannella, R. A., and Greenberg, R. N. (2004). Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Kidney Int. 65, 40-53.
6. Carrithers, S. L., Taylor, B., Cai, W. Y., Johnson, B. R., Ott, C. E., Green berg,R. N.,and Jackson,B.A. (2000). Guanylyl cyclase-C receptor mRNA distribution along the rat nephron. Regul. Pept. 95, 65-74.
7. Currie, M. G., Fok, K. F., Kato, J., Moore, R. J., Hamra, F. K., Duffin, K. L., and Smith, C. E. (1992). Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 89, 947-951.
8. Field, M., Graf, L. H. Jr., Laird, W. J., and Smith, P. L. (1978). Heat stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc. Natl. Acad. Sci. U.S.A. 75, 2800-2804.
9. Fonteles, M. C., Havt, A., Prata, R. B., Prata, P. H., Monteiro, H. S., Lima,A. A., Jorge, A. R., Santos, C. F., Greenberg, R. N., and Nascimento, N. R. (2009). High-salt intake primes the rat kidney to respond to a subthreshold uroguanylin dose during ex vivo renal perfusion. Regul. Pept. 158, 6-13.
10. Forte, L. R. (1999). Guanylin regulatory peptides: structures,biological activ- ities mediated by cyclic GMP and pathobiology. Regul. Pept. 81, 25-39. Forte, L. R. (2003). A novel role for uroguanylin in the regulation of sodium balance. J. Clin. Invest. 112, 1138-1141.
11. Forte, L. R. (2003). A novel role for uroguanylin in the regulation ofsodium balance. J. Clin. Invest. 112, 1138-1141.
12. Fulle, H. J.,Vassar, R., Foster, D. C.,Yang, R. B., Axel, R., and Garbers, D. L. (1995). A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc. Natl. Acad. Sci. U.S.A. 92, 3571-3575.
13. Hamra, F. K.,Forte, L. R., Eber, S. L., Pidhorodeckyj, N.V., Krause,W. J.,Freeman, R. H., Chin, D. T., Tompkins, J. A., Fok, K. F., Smith, C. E., Duffin, K. L., Siegel, N. R., and Currie, M. G. (1993). Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 90, 10464-10468.
14. Hu, J., Zhong, C., Ding, C., Chi, Q., Walz, A., Mombaerts, P., Matsunami, H., and Luo, M. (2007). Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science 317, 953-957.
15. Jaleel, M., London, R. M., Eber, S. L., Forte, L. R., and Visweswariah, S. S. (2002). Expression of the receptor guanylyl cyclase C and its ligands in reproductive tissues of the rat: a potential role for a novel signaling pathway in the epididymis. Biol. Reprod. 67, 1975-1980.
16. Kloeters, O.,Friess, H.,Giese,N.,Buechler, M. W., Cetin, Y., and Kulaksiz, H. (2008). Uroguanylin inhibits proliferation of pancreatic cancer cells. Scand. J. Gastroenterol. 43, 447-455.
17. Krause, W. J., London, R. M., Freeman, R. H., and Forte, L. R. (1997). The guanylin and uroguanylin peptide hormones and their receptors. Acta Anat (Basel) 160, 213-231.
18. Leinders-Zufall, T., Cockerham, R. E., Michalakis, S., Biel, M., Garbers, D. L.,Reed,R. R.,Zufall,F.,and Munger, S. D. (2007). Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc. Natl.Acad. Sci. U.S.A. 104, 14507-14512.
19. Lorenz, J. N., Nieman, M., Sabo, J., Sanford, L. P., Hawkins, J. A., Elitsur, N., Gawenis, L. R., Clarke, L. L., and Cohen, M. B. (2003). Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. J. Clin. Invest. 112, 1244-1254.
20. Meyer, M. R., Angele, A., Kremmer, E., Kaupp, U. B., and Muller, F. (2000). A cGMP-signaling pathway in a subset of olfactory sensory neurons. Proc. Natl. Acad. Sci. U.S.A. 97, 10595-10600.
21. Moss, N. G., Fellner, R. C., Qian, X., Yu, S. J., Li, Z., Nakazato, M., and Goy, M. F. (2008). Uroguanylin, an intestinal natriuretic peptide,is delivered to the kidney as an unprocessed propeptide. Endocrinology 149, 4486-4498.
22. Munger, S. D., Leinders-Zufall, T., Mcdougall, L. M., Cockerham, R. E., Schmid, A., Wandernoth, P., Wennemuth, G., Biel, M., Zufall, F., and Kelliher, K. R. (2010). An olfactory subsystem that detects carbon disulfide and mediates food related social learning. Curr. Biol. 20, 1438-1444.
23. Pitari, G. M., Baksh, R. I., Harris, D. M., Li, P., Kazerounian, S., and Waldman, S. A. (2005). Interruption of homologous desensitization in cyclic guanosine 3',5'- monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res. 65, 11129-11135.
24. Pitari, G. M., Di Guglielmo, M. D., Park, J., Schulz, S., and Waldman, S. A. (2001). Guanylyl cyclase C agonists regulate progression through the cell cycle ofhuman colon carcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 98, 7846-7851.
25. Pitari, G. M., Zingman, L. V., Hodgson, D. M., Alekseev, A. E., Kazerounian, S., Bienengraeber, M., Hajnoczky, G., Terzic, A., and Waldman, S. A. (2003). Bacterial enterotoxins are associated with resistance to colon cancer. Proc. Natl. Acad. Sci. U.S.A. 100, 2695-2699.
26. Qian, X., Moss, N. G., Fellner, R. C., and Goy, M. F. (2008). Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules. Endocrinology 149, 4499-4509.
27. Schulz, S., Green, C. K., Yuen, P. S., and Garbers, D. L. (1990). Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell 63, 941-948.
28. Shailubhai, K., Yu, H. H., Karunanandaa, K., Wang, J. Y., Eber, S. L., Wang, Y., Joo, N. S., Kim, H. D., Miedema,B.W.,Abbas,S. Z.,Boddupalli, S. S., Currie, M. G., and Forte, L. R. (2000). Uroguanylin treatment suppresses polyp formation in the Apc(Min/+ mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res. 60, 5151-5157.
29. Sindic, A., and Schlatter, E. (2006). Cellular effects of guanylin and uroguanylin. J. Am. Soc. Nephrol. 17, 607-616.
30. Sindice, A., Basoglu, C., Cerci, A., Hirsch, J. R., Potthast, R., Kuhn, M., Ghanekar, Y., Visweswariah, S. S., and Schlatter, E. (2002). Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin- sensitive G protein in human proximal tubule cells. J. Biol. Chem. 277, 17758-17764.
31. Sousa, C. M., Havt, A., Santos, C. F., Arnaud-Batista, F. J., Cunha, K. M., Cerqueira, J. B., Fonteles, M. C., and Nascimento, N. R. (2010). The relaxation induced by uroguanylin and the expression of natriuretic peptide receptors in human corpora cavernosa. J. Sex. Med. 7, 3610-3619.
32. Sun, L., Wang, H., Hu, J., Han, J., Matsunami, H., and Luo, M. (2009). Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. Proc. Natl. Acad. Sci. U.S.A. 106, 2041-2046.
33. Yuge, S., Inoue, K., Hyodo, S., and Takei, Y. (2003). A novel guanylin family (guanylin, uroguanylin, and renoguanylin) in eels: possible osmoregulatory hormones in intestine and kidney. J. Biol. Chem. 278, 22726-22733.
34. Zufall, F., and Munger, S. D. (2010). Receptor guanylyl cyclases in mammalian olfactory function. Mol. Cell. Biochem. 334, 191-197.