메뉴 건너뛰기




Volumn 39, Issue 2, 2013, Pages 117-126

The novel oral anticoagulants

Author keywords

anticoagulants; apixaban; dabigatran; oral anticoagulants; rivaroxaban

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; APIXABAN; ATECEGATRAN METOXIL; BETRIXABAN; CLOPIDOGREL; DABIGATRAN; DABIGATRAN ETEXILATE; DAREXABAN; EDOXABAN; ENOXAPARIN; ERIBAXABAN; FONDAPARINUX; LETAXABAN; LOW MOLECULAR WEIGHT HEPARIN; N [2 [4 (1 METHYL 4 PIPERIDINYL) 1 PIPERAZINYL] 2 OXO 1 PHENYLETHYL] 1H INDOLE 6 CARBOXAMIDE; RIVAROXABAN; TICLOPIDINE; TTP 889; UNCLASSIFIED DRUG; WARFARIN;

EID: 84874193968     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0032-1333536     Document Type: Article
Times cited : (24)

References (54)
  • 2
    • 77955451612 scopus 로고    scopus 로고
    • Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: Comparison with direct inhibitors of factor VIIa, XIa and thrombin
    • Wong P. C., Jiang X. Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. Thromb Haemost: 2010; 104 2 302 310
    • (2010) Thromb Haemost , vol.104 , Issue.2 , pp. 302-310
    • Wong, P.C.1    Jiang, X.2
  • 3
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • et al.
    • Raghavan N., Frost C. E., Yu Z., et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos: 2009; 37 1 74 81
    • (2009) Drug Metab Dispos , vol.37 , Issue.1 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 4
    • 84871397647 scopus 로고    scopus 로고
    • ® (INN - apixaban) Summary of Product Characteristics
    • ® (INN - apixaban) Summary of Product Characteristics. http://ec.europa.eu/health/documents/ community-register/2011/20110518102349/anx-102349-en.pdf
    • Bristol-Myers Squibb/Pfizer
  • 5
    • 79251511891 scopus 로고    scopus 로고
    • Tissue distribution and elimination of [14C]apixaban in rats
    • et al.
    • Wang L., He K., Maxwell B., et al. Tissue distribution and elimination of [14C]apixaban in rats. Drug Metab Dispos: 2011; 39 2 256 264
    • (2011) Drug Metab Dispos , vol.39 , Issue.2 , pp. 256-264
    • Wang, L.1    He, K.2    Maxwell, B.3
  • 6
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • DOI 10.1016/j.clpt.2005.06.011, PII S000992360500281X
    • Kubitza D., Becka M., Voith B., Zuehlsdorf M., Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther: 2005; 78 4 412 421 (Pubitemid 41393676)
    • (2005) Clinical Pharmacology and Therapeutics , vol.78 , Issue.4 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 8
    • 66449087353 scopus 로고    scopus 로고
    • In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans
    • Lang D., Freudenberger C., Weinz C. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Drug Metab Dispos: 2009; 37 5 1046 1055
    • (2009) Drug Metab Dispos , vol.37 , Issue.5 , pp. 1046-1055
    • Lang, D.1    Freudenberger, C.2    Weinz, C.3
  • 9
    • 79959522836 scopus 로고    scopus 로고
    • In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban
    • Gnoth M. J., Buetehorn U., Muenster U., Schwarz T., Sandmann S. In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban. J Pharmacol Exp Ther: 2011; 338 1 372 380
    • (2011) J Pharmacol Exp Ther , vol.338 , Issue.1 , pp. 372-380
    • Gnoth, M.J.1    Buetehorn, U.2    Muenster, U.3    Schwarz, T.4    Sandmann, S.5
  • 10
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • DOI 10.1111/j.1365-2125.2007.02899.x
    • Stangier J., Rathgen K., Stähle H., Gansser D., Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol: 2007; 64 3 292 303 (Pubitemid 47283865)
    • (2007) British Journal of Clinical Pharmacology , vol.64 , Issue.3 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 11
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • DOI 10.1124/dmd.107.019083
    • Blech S., Ebner T., Ludwig-Schwellinger E., Stangier J., Roth W. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos: 2008; 36 2 386 399 (Pubitemid 351185753)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.2 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Roth, W.5
  • 13
    • 84864808150 scopus 로고    scopus 로고
    • Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin
    • et al.
    • Härtter S., Koenen-Bergmann M., Sharma A., et al. Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin. Br J Clin Pharmacol: 2012; 74 3 490 500
    • (2012) Br J Clin Pharmacol , vol.74 , Issue.3 , pp. 490-500
    • Härtter, S.1    Koenen-Bergmann, M.2    Sharma, A.3
  • 14
    • 84874194042 scopus 로고    scopus 로고
    • Accessed: February 1, 2013
    • Boerhinger-Ingelheim. Dabigatran Advisory Committee Briefing Document. Available at: http://www.fda.gov/downloads/advisorycommittees/ committeesmeetingmaterials/drugs/cardiovascularandrenaldrugsadvisorycommittee/ ucm226009.pdf. Accessed: February 1, 2013
    • Boerhinger-Ingelheim. Dabigatran Advisory Committee Briefing Document
  • 15
  • 16
    • 77649113258 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): A randomised double-blind trial
    • ADVANCE-2 investigators
    • Lassen M. R., Raskob G. E., Gallus A., Pineo G., Chen D., Hornick P. ADVANCE-2 investigators Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. Lancet: 2010; 375 9717 807 815
    • (2010) Lancet , vol.375 , Issue.9717 , pp. 807-815
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3    Pineo, G.4    Chen, D.5    Hornick, P.6
  • 17
    • 78650587760 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    • ADVANCE-3 Investigators
    • Lassen M. R., Gallus A., Raskob G. E., Pineo G., Chen D., Ramirez L. M. ADVANCE-3 Investigators Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med: 2010; 363 26 2487 2498
    • (2010) N Engl J Med , vol.363 , Issue.26 , pp. 2487-2498
    • Lassen, M.R.1    Gallus, A.2    Raskob, G.E.3    Pineo, G.4    Chen, D.5    Ramirez, L.M.6
  • 18
    • 83155193223 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients
    • et al. ADOPT Trial Investigators
    • Goldhaber S. Z., Leizorovicz A., Kakkar A. K., et al. ADOPT Trial Investigators Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients. N Engl J Med: 2011; 365 23 2167 2177
    • (2011) N Engl J Med , vol.365 , Issue.23 , pp. 2167-2177
    • Goldhaber, S.Z.1    Leizorovicz, A.2    Kakkar, A.K.3
  • 19
    • 47649098524 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study
    • DOI 10.1111/j.1538-7836.2008.03054.x
    • Buller H., Deitchman D., Prins M., Segers A. Botticelli Investigators, Writing Committee Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost: 2008; 6 8 1313 1318 (Pubitemid 352016310)
    • (2008) Journal of Thrombosis and Haemostasis , vol.6 , Issue.8 , pp. 1313-1318
    • Buller, H.1    Deitchman, D.2    Prins, M.3    Segers, A.4
  • 20
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
    • et al. APPRAISE Steering Committee and Investigators
    • Alexander J. H., Becker R. C., Bhatt D. L., et al. APPRAISE Steering Committee and Investigators Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation: 2009; 119 22 2877 2885
    • (2009) Circulation , vol.119 , Issue.22 , pp. 2877-2885
    • Alexander, J.H.1    Becker, R.C.2    Bhatt, D.L.3
  • 21
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • et al. APPRAISE-2 Investigators
    • Alexander J. H., Lopes R. D., James S., et al. APPRAISE-2 Investigators Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med: 2011; 365 8 699 708
    • (2011) N Engl J Med , vol.365 , Issue.8 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 22
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • et al. ARISTOTLE Committees and Investigators
    • Granger C. B., Alexander J. H., McMurray J. J., et al. ARISTOTLE Committees and Investigators Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med: 2011; 365 11 981 992
    • (2011) N Engl J Med , vol.365 , Issue.11 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 23
    • 77649254746 scopus 로고    scopus 로고
    • Rationale and design of AVERROES: Apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment
    • et al. e1
    • Eikelboom J. W., O'Donnell M., Yusuf S., et al. Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment. Am Heart J: 2010; 159 3 348, e1
    • (2010) Am Heart J , vol.159 , Issue.3 , pp. 348
    • Eikelboom, J.W.1    O'Donnell, M.2    Yusuf, S.3
  • 25
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled trial
    • et al. RECORD2 Investigators
    • Kakkar A. K., Brenner B., Dahl O. E., et al. RECORD2 Investigators Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet: 2008; 372 9632 31 39
    • (2008) Lancet , vol.372 , Issue.9632 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 27
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • et al. RECORD4 Investigators
    • Turpie A. G., Lassen M. R., Davidson B. L., et al. RECORD4 Investigators Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet: 2009; 373 9676 1673 1680
    • (2009) Lancet , vol.373 , Issue.9676 , pp. 1673-1680
    • Turpie, A.G.1    Lassen, M.R.2    Davidson, B.L.3
  • 28
    • 79952496003 scopus 로고    scopus 로고
    • Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies
    • et al.
    • Turpie A. G., Lassen M. R., Eriksson B. I., et al. Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies. Thromb Haemost: 2011; 105 3 444 453
    • (2011) Thromb Haemost , vol.105 , Issue.3 , pp. 444-453
    • Turpie, A.G.1    Lassen, M.R.2    Eriksson, B.I.3
  • 29
    • 80052341686 scopus 로고    scopus 로고
    • Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol
    • et al.
    • Cohen A. T., Spiro T. E., Büller H. R., et al. Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol. J Thromb Thrombolysis: 2011; 31 4 407 416
    • (2011) J Thromb Thrombolysis , vol.31 , Issue.4 , pp. 407-416
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3
  • 31
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • et al. EINSTEIN Investigators
    • Bauersachs R., Berkowitz S. D., Brenner B., et al. EINSTEIN Investigators Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med: 2010; 363 26 2499 2510
    • (2010) N Engl J Med , vol.363 , Issue.26 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 32
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • et al. EINSTEIN-PE Investigators
    • Büller H. R., Prins M. H., Lensin A. W., et al. EINSTEIN-PE Investigators Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med: 2012; 366 14 1287 1297
    • (2012) N Engl J Med , vol.366 , Issue.14 , pp. 1287-1297
    • Büller, H.R.1    Prins, M.H.2    Lensin, A.W.3
  • 33
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • et al. ATLAS ACS 2-TIMI 51 Investigators
    • Mega J. L., Braunwald E., Wiviott S. D., et al. ATLAS ACS 2-TIMI 51 Investigators Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med: 2012; 366 1 9 19
    • (2012) N Engl J Med , vol.366 , Issue.1 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 34
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • et al. ROCKET AF Investigators
    • Patel M. R., Mahaffey K. W., Garg J., et al. ROCKET AF Investigators Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med: 2011; 365 10 883 891
    • (2011) N Engl J Med , vol.365 , Issue.10 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 37
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • et al. RE-MOBILIZE Writing Committee
    • Ginsberg J. S., Davidson B. L., Comp P. C., et al. RE-MOBILIZE Writing Committee Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty: 2009; 24 1 1 9
    • (2009) J Arthroplasty , vol.24 , Issue.1 , pp. 1-9
    • Ginsberg, J.S.1    Davidson, B.L.2    Comp, P.C.3
  • 38
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • et al. RE-COVER Study Group
    • Schulman S., Kearon C., Kakkar A. K., et al. RE-COVER Study Group Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med: 2009; 361 24 2342 2352
    • (2009) N Engl J Med , vol.361 , Issue.24 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 40
    • 84862530985 scopus 로고    scopus 로고
    • A randomized trial of dabigatran versus warfarin in the treatment of acute venous thromboembolism (RE-COVER II)
    • San Diego, CA, 2011
    • Schulman S., Kakkar A. K., Schellong S. M., et al. A randomized trial of dabigatran versus warfarin in the treatment of acute venous thromboembolism (RE-COVER II). The American Society of Hematology 2011 Annual Meeting. San Diego, CA, 2011
    • The American Society of Hematology 2011 Annual Meeting
    • Schulman, S.1    Kakkar, A.K.2    Schellong, S.M.3
  • 42
    • 80052232522 scopus 로고    scopus 로고
    • Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial
    • et al. RE-DEEM Investigators
    • Oldgren J., Budaj A., Granger C. B., et al. RE-DEEM Investigators Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J: 2011; 32 22 2781 2789
    • (2011) Eur Heart J , vol.32 , Issue.22 , pp. 2781-2789
    • Oldgren, J.1    Budaj, A.2    Granger, C.B.3
  • 43
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • et al. RE-LY Steering Committee and Investigators
    • Connolly S. J., Ezekowitz M. D., Yusuf S., et al. RE-LY Steering Committee and Investigators Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med: 2009; 361 12 1139 1151
    • (2009) N Engl J Med , vol.361 , Issue.12 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 44
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    • et al.
    • Eikelboom J. W., Wallentin L., Connolly S. J., et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation: 2011; 123 21 2363 2372
    • (2011) Circulation , vol.123 , Issue.21 , pp. 2363-2372
    • Eikelboom, J.W.1    Wallentin, L.2    Connolly, S.J.3
  • 45
    • 79957715797 scopus 로고    scopus 로고
    • Anticoagulant options-why the FDA approved a higher but not a lower dose of dabigatran
    • Beasley B. N., Unger E. F., Temple R. Anticoagulant options-why the FDA approved a higher but not a lower dose of dabigatran. N Engl J Med: 2011; 364 19 1788 1790
    • (2011) N Engl J Med , vol.364 , Issue.19 , pp. 1788-1790
    • Beasley, B.N.1    Unger, E.F.2    Temple, R.3
  • 46
    • 84870517411 scopus 로고    scopus 로고
    • Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: A systematic review
    • Adam S. S., McDuffie J. R., Ortel T. L., Williams J. W. Jr. Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review. Ann Intern Med: 2012
    • (2012) Ann Intern Med
    • Adam, S.S.1    McDuffie, J.R.2    Ortel, T.L.3    Illiams Jr., J.W.4
  • 47
    • 77952044405 scopus 로고    scopus 로고
    • Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor
    • et al.
    • Samama M. M., Martinoli J. L., LeFlem L., et al. Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor. Thromb Haemost: 2010; 103 4 815 825
    • (2010) Thromb Haemost , vol.103 , Issue.4 , pp. 815-825
    • Samama, M.M.1    Martinoli, J.L.2    Leflem, L.3
  • 48
    • 79851482951 scopus 로고    scopus 로고
    • Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays
    • et al. Expert group on coagulation of the external quality assurance in laboratory medicine in Sweden
    • Lindahl T. L., Baghaei F., Blixter I. F., et al. Expert group on coagulation of the external quality assurance in laboratory medicine in Sweden Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays. Thromb Haemost: 2011; 105 2 371 378
    • (2011) Thromb Haemost , vol.105 , Issue.2 , pp. 371-378
    • Lindahl, T.L.1    Baghaei, F.2    Blixter, I.F.3
  • 49
    • 84860548394 scopus 로고    scopus 로고
    • Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy
    • Avecilla S. T., Ferrell C., Chandler W. L., Reyes M. Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy. Am J Clin Pathol: 2012; 137 4 572 574
    • (2012) Am J Clin Pathol , vol.137 , Issue.4 , pp. 572-574
    • Avecilla, S.T.1    Ferrell, C.2    Chandler, W.L.3    Reyes, M.4
  • 50
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • Stangier J., Feuring M. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis: 2012; 23 2 138 143
    • (2012) Blood Coagul Fibrinolysis , vol.23 , Issue.2 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 51
    • 84859971855 scopus 로고    scopus 로고
    • Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
    • et al. 01
    • Kaatz S., Kouides P. A., Garcia D. A., et al. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. Am J Hematol: 2012; 87 01 S141 S145
    • (2012) Am J Hematol , vol.87
    • Kaatz, S.1    Kouides, P.A.2    Garcia, D.A.3
  • 52
    • 82555172355 scopus 로고    scopus 로고
    • Dabigatran: Review of pharmacology and management of bleeding complications of this novel oral anticoagulant
    • Ganetsky M., Babu K. M., Salhanick S. D., Brown R. S., Boyer E. W. Dabigatran: review of pharmacology and management of bleeding complications of this novel oral anticoagulant. J Med Toxicol: 2011; 7 4 281 287
    • (2011) J Med Toxicol , vol.7 , Issue.4 , pp. 281-287
    • Ganetsky, M.1    Babu, K.M.2    Salhanick, S.D.3    Brown, R.S.4    Boyer, E.W.5
  • 53
    • 84873898236 scopus 로고    scopus 로고
    • Sulfated Pentagalloylglucoside Is a Potent, Allosteric, and Selective Inhibitor of Factor XIa
    • (e-pub ahead of print)
    • Al-Horani R. A., Ponnusamy P., Mehta A. Y., Gailani D., Desai U. R. Sulfated Pentagalloylglucoside Is a Potent, Allosteric, and Selective Inhibitor of Factor XIa. J Med Chem: 2013; (e-pub ahead of print)
    • (2013) J Med Chem
    • Al-Horani, R.A.1    Ponnusamy, P.2    Mehta, A.Y.3    Gailani, D.4    Desai, U.R.5
  • 54
    • 84867628649 scopus 로고    scopus 로고
    • Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation
    • Ahrens I., Peter K., Lip G. Y., Bode C. Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation. Discov Med: 2012; 13 73 445 450
    • (2012) Discov Med , vol.13 , Issue.73 , pp. 445-450
    • Ahrens, I.1    Peter, K.2    Lip, G.Y.3    Bode, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.