Increased risk of major depression by childhood abuse is not modified by CNR1 genotype

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 162, Issue 2, 2013, Pages 224-226

  Pearson, John F ^a   Fergusson, David M ^a   Horwood, L John ^a   Miller, Allison L ^a   Sullivan, Patrick F ^b   Youfang, Liu E ^b   Kennedy, Martin A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHILD ABUSE; CHILD SEXUAL ABUSE; DISEASE PREDISPOSITION; DSM-IV; GENETIC ASSOCIATION; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; NEW ZEALAND; NEWBORN; PHYSICAL ABUSE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; PUNISHMENT; RETROSPECTIVE STUDY; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ALLELES; CASE-CONTROL STUDIES; CHILD; CHILD ABUSE; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, CANNABINOID, CB1; RISK FACTORS; YOUNG ADULT;

EID: 84874127971     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32124     Document Type: Article

References (12)

1. Agrawal A, Nelson EC, Littlefield AK, Bucholz KK, Degenhardt L, Henders AK, Madden PA, Martin NG, Montgomery GW, Pergadia ML., et al. 2012. Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. Arch Gen Psychiatry 69(7): 732-740.
2. Fergusson DM, Boden JM, Horwood LJ, Miller AL, Kennedy MA. 2011a. MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. Br J Psychiatry 198(6): 457-463.
3. Fergusson DM, Horwood LJ. 2001. The Christchurch Health and Development Study: Review of findings on child and adolescent mental health. Aust N Z J Psychiatry 35(3): 287-296.
4. Fergusson DM, Horwood LJ, Miller AL, Kennedy MA. 2011b. Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. Br J Psychiatry 198(2): 129-135.
5. Fergusson DM, Horwood LJ, Shannon FT, Lawton JM. 1989. The Christchurch child development study: A review of epidemiological findings. Paediatr Perinat Epidemiol 3(3): 302-325.
6. Hodgkinson CA, Yuan Q, Xu K, Shen PH, Heinz E, Lobos EA, Binder EB, Cubells J, Ehlers CL, Gelernter J., et al. 2008. Addictions biology: Haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol 43(5): 505-515.
7. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. 2001. Replication validity of genetic association studies. Nat Genet 29(3): 306-309.
8. Juhasz G, Chase D, Pegg E, Downey D, Toth ZG, Stones K, Platt H, Mekli K, Payton A, Elliott R., et al. 2009. CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacology 34(8): 2019-2027.
9. Kavvoura FK, Ioannidis JP. 2008. Methods for meta-analysis in genetic association studies: A review of their potential and pitfalls. Hum Genet 123(1): 1-14.
10. Munafo MR, Flint J. 2009. Replication and heterogeneity in gene x environment interaction studies. Int J Neuropsychopharmacol 12(6): 727-729.
11. Munafo MR, Stothart G, Flint J. 2009. Bias in genetic association studies and impact factor. Mol Psychiatry 14(2): 119-120.
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ., et al. 2007. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3): 559-575.