Independent and synergistic associations of asthma and obesity with systemic inflammation in adolescents

Journal of Asthma

Volumn 49, Issue 10, 2012, Pages 1044-1050

  Khan, Unab I ^a   Rastogi, Deepa ^b   Isasi, Carmen R ^b   Coupey, Susan M ^a  

^a CHILDREN S HOSPITAL AT MONTEFIORE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Adolescents; Asthma; High sensitivity C reactive protein; Obesity

Indexed keywords

ADOLESCENT; ARTICLE; ASTHMA; BODY WEIGHT; CARDIOVASCULAR RISK; EXERCISE TEST; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GROUPS BY AGE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OBESITY; PROTEIN BLOOD LEVEL;

ADOLESCENT; ADULT; ASTHMA; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHILD; CROSS-SECTIONAL STUDIES; EXERCISE; FEMALE; HUMANS; INFLAMMATION; MALE; NEW YORK CITY; OBESITY; RESPIRATORY FUNCTION TESTS; RISK FACTORS; SOCIOECONOMIC FACTORS;

EID: 84874124226     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2012.728271     Document Type: Article

References (47)

1. Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003-2006. JAMA 2008; 299:2401-2405 (Pubitemid 351749238)
2. NYC Department of Health and Human Hygiene. Community health profiles - Fordham and Bronx Park. 2006. Available at: Http://www.nyc. gov/html/doh/ downloads/pdf/data/2006chp-103.pdf. Accessed August 24, 2011
3. Diabetes and Obesity in New York City. In: NYC Department of Health and Mental Hygiene Community Health Survey. 2007
4. Gennuso J, Epstein LH, Paluch RA, Cerny F. The relationship between asthma and obesity in urban minority children and adolescents. Arch Pediatr Adolesc Med 1998; 152:1197-1200 (Pubitemid 28558106)
5. Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: A meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007; 175:661-666 (Pubitemid 46536480)
6. Schanen JG, Iribarren C, Shahar E, Punjabi NM, Rich SS, Sorlie PD, Folsom AR. Asthma and incident cardiovascular disease: The Atherosclerosis Risk in Communities Study. Thorax 2005; 60:633-638 (Pubitemid 41129060)
7. Must A, Strauss RS. Risks and consequences of childhood and adolescent obesity. Int J Obes Relat Metab Disord 1999; 23,(Suppl 2):S2-S11 (Pubitemid 29182357)
8. Orio F Jr., Palomba S, Cascella T, et al. Cardiovascular complications of obesity in adolescents. J Endocrinol Invest 2007; 30:70-80 (Pubitemid 46470387)
9. Luc G, Bard JM, Juhan-Vague I, Ferrieres J, Evans A, Amouyel P, Arveiler D, Fruchart JC, Ducimetiere P; PRIME Study Group. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: The PRIME Study. Arterioscler Thromb Vasc Biol 2003; 23:1255-1261 (Pubitemid 36871282)
10. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999; 282:2131-2135
11. Glowinska B, Urban M, Koput A, Galar M. New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents. Atherosclerosis 2003; 167:275-286 (Pubitemid 36773527)
12. Haahtela T, Laitinen LA. Asthma programme in Finland 1994-2004. Report of a working group. Clinical and experimental allergy: J British Soc Allergy Clin Immunol 1996; 26,(Suppl 1): I-ii, 1-24
13. Jousilahti P, Salomaa V, Hakala K, Rasi V, Vahtera E, Palosuo T. The association of sensitive systemic inflammation markers with bronchial asthma. Ann Allergy Asthma Immunol 2002; 89:381-385 (Pubitemid 36188009)
14. Olafsdottir IS, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jögi R, Janson C. C reactive protein levels are increased in non-allergic but not allergic asthma: A multicentre epidemiological study. Thorax 2005; 60:451-454 (Pubitemid 40814042)
15. Huang F, del-Río-Navarro BE, Monge JJ, Torres Alcántara S, Ontiveros JA, Olivos EN, Martínez de Castro NG, Zhao L, Hong E. Endothelial activation and systemic inflammation in obese asthmatic children. Allergy Asthma Proc 2008; 29:453-460
16. Michelson PH, Williams LW, Benjamin DK, Barnato AE. Obesity, inflammation, and asthma severity in childhood: Data from the National Health and Nutrition Examination Survey 2001-2004. Ann Allergy Asthma Immunol 2009; 103:381-385
17. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, Rimm EB. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004; 351:2599-2610 (Pubitemid 39628581)
18. Wang TJ, Larson MG, Levy D, Benjamin EJ, Kupka MJ, Manning WJ, Clouse ME, D'Agostino RB, Wilson PW, O'Donnell CJ. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: The Framingham Heart Study. Circulation 2002; 106:1189-1191 (Pubitemid 34988633)
19. Reinehr T, Kiess W, de Sousa G, Stoffel-Wagner B, Wunsch R. Intima media thickness in childhood obesity: Relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006; 55:113-118 (Pubitemid 41736256)
20. Ikonomidis I, Stamatelopoulos K, Lekakis J,VamvakouGD, Kremastinos DT. Inflammatory and non-invasive vascular markers: The multimarker approach for risk stratification in coronary artery disease. Atherosclerosis 2008; 199:3-11
21. Expert Panel Report 3. Guidelines for the Diagnosis and Management of Asthma. In: National Heart Lung and Blood Institute National Asthma Education and Prevention Program. 2007. Available at: Http://www.nhlbi. nih.gov/guidelines/asthma/asthgdln.htm. Accessed August 24, 2011
22. Division of Public Health Surveillance and Informatics CfDC. Epi Info 2002 - Revision 2 In. Division of Public Health Surveillance and Informatics. Center for Disease Control. January 30, 2003
23. Aaron DJ, Kriska AM, Dearwater SR, Anderson RL, Olsen TL, Cauley JA, Laporte RE. The epidemiology of leisure physical activity in an adolescent population. Med Sci Sports Exerc 1993; 25:847-853 (Pubitemid 23207150)
24. ATS statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166:111-117
25. Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest 2001; 119:256-270 (Pubitemid 32150576)
26. Loeb JS, Blower WC, Feldstein JF, Koch BA, Munlin AL, Hardie WD. Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria. Pediatr pulmonol 2008; 43:1020-1024
27. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U. S. population. Am J Respir Crit Care Med 1999; 159:179-187 (Pubitemid 29036522)
28. Rifai N, Ridker PM. High-sensitivity C-reactive protein: A novel and promisingmarker of coronary heart disease. Clin Chem2001; 47:403-411 (Pubitemid 32222452)
29. Balagopal P, George D, Patton N, Yarandi H, Roberts WL, Bayne E, Gidding S. Lifestyle-only intervention attenuates the inflammatory state associated with obesity: A randomized controlled study in adolescents. [see comment]. J Pediatr 2005; 146:342-348 (Pubitemid 40341743)
30. Zeno SA, Kim-Dorner SJ, Deuster PA, Davis JL, Remaley AT, Poth M. Cardiovascular fitness and risk factors of healthy African Americans and Caucasians. J Natl Med Assoc 2010; 102:28-35
31. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007; 56:1010-1013 (Pubitemid 46525079)
32. Maury E, Ehala-Aleksejev K, Guiot Y, Detry R, Vandenhooft A, Brichard SM. Adipokines oversecreted by omental adipose tissue in human obesity. Am J Physiol Endocrinol Metab 2007; 293:E656-665
33. Heijink IH, Vellenga E, Borger P, Postma DS, de Monchy JG, Kauffman HF. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and - independent mechanisms in freshly isolated human T cells. Immunology 2002; 107:316-324 (Pubitemid 35356951)
34. Thomas PS. Tumour necrosis factor-alpha: The role of this multifunctional cytokine in asthma. Immunol Cell Biol 2001; 79:132-140 (Pubitemid 32281083)
35. Sukkar MB, Hughes JM, Armour CL, Johnson PR. Tumour necrosis factor-alpha potentiates contraction of human bronchus in vitro. Respirology 2001; 6:199-203 (Pubitemid 32896549)
36. Bekkers MB, Brunekreef B, de Jongste JC, Kerkhof M, Smit HA, Postma DS, Gehring U, Wijga AH. Childhood overweight and asthma symptoms, the role of pro-inflammatory proteins. Clin Exp Allergy 2012; 42:95-103
37. Deraz TE, Kamel TB, El-Kerdany TA, El-Ghazoly HMA. Highsensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry. Pediatr pulmonol 2012; 47:220-225
38. Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, Miller GJ, Strachan DP. C-reactive protein concentration in children: Relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 2000; 149:139-150 (Pubitemid 30125982)
39. Sutherland TJ, Cowan JO, Young S, Goulding A, Grant AM, Williamson A, Brassett K, Herbison GP, Taylor DR. The association between obesity and asthma: Interactions between systemic and airway inflammation. Am J Respir Crit Care Med 2008; 178:469-475
40. Kony S, Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F. Association of bronchial hyperresponsiveness and lung function with C-reactive protein, (CRP): A population based study. Thorax 2004; 59:892-896 (Pubitemid 39389631)
41. Mendall MA, Strachan DP, Butland BK, Ballam L, Morris J, Sweetnam PM, Elwood PC. C-reactive protein: Relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men. Eur Heart J 2000; 21:1584-1590
42. Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH, Dietz WH. C-reactive protein and body mass index in children: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994. J Pediatr 2001; 138:486-492
43. Rogowski O, Shapira I, Toker S, Melamed S, Shirom A, Berliner S, Zeltser D. Obesity-related correlation between C-reactive protein and the calculated 10-y Framingham Coronary Heart Disease Risk Score. Int J Obes, (Lond) 2005; 29:772-777 (Pubitemid 40897013)
44. Ford ES, Giles WH, Myers GL, Rifai N, Ridker PM, Mannino DM. C-reactive protein concentration distribution among US children and young adults: Findings from the National Health and Nutrition Examination Survey, 1999-2000. Clin Chem 2003; 49:1353-1357
45. Alley DE, Seeman TE, Ki Kim J, Karlamangla A, Hu P, Crimmins EM. Socioeconomic status and C-reactive protein levels in the US population: NHANES IV. Brain, Behavior, & Immunity 2006; 20:498-504 (Pubitemid 44175794)
46. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012; 307:483-490
47. Toren K, Lindholm NB. Do patients with severe asthma run an increased risk from ischaemic heart disease? Int J Epidemiol 1996; 25:617-620 (Pubitemid 26229564)