The antiproliferative activity of 3-deoxyanthocyanins extracted from red sorghum (Sorghum bicolor) bran through P53-dependent and Bcl-2 gene expression in breast cancer cell line

Life Sciences

Volumn 92, Issue 6-7, 2013, Pages 379-382

  Suganyadevi, P ^a   Saravanakumar, K M ^a   Mohandas, S ^b  

^a NGM COLLEGE   (India)

^b Kaamadhenu Arts and Science College   (India)

Author keywords

3 deoxyanthocyanins; Breast cancer cell line; Red sorghum bran

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 3 DEOXYANTHOCYANIN; ANTHOCYANIN; MESSENGER RNA; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BRAN; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG ISOLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SORGHUM;

ANTHOCYANINS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; SORGHUM; TUMOR SUPPRESSOR PROTEIN P53;

SORGHUM BICOLOR;

EID: 84874118007     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.01.006     Document Type: Article

References (11)

1. J.M. Awika Behavior of 3-deoxyanthocyanidins in the presence of phenolic copigments Food Res Int 42 2008 532 538
2. J.M. Awika, and L.W. Rooney Phytochemicals from sorghum and their impact on human health Phytochemistry 65 2004 1199 1221
3. J.M. Awika, L.W. Rooney, and R.D. Waniska Anthocyanins from black sorghum and their antioxidant properties Food Chem 90 2005 293 304
4. E. Azizi, M.H. Abdolmohammadi, Sh. Fouladdel, A. Shafiee, Gh. Amin, and S.M. Ghaffari Evaluation of p53 and Bcl-2 genes and proteins expression in human breast cancer T47D cells treated with extracts of Astrodaucuspersicus(Boiss.) Drude in comparison to Tamoxifen DARU 17 3 2009 193 197
5. G. Azza, and R. Brouillard Color stability and structural transformations of cyaniding 3,5-diglucoside and four 3-deoxyanthocyanins in aqueous solutions J Agric Food Chem 35 1987 422 426
6. D. Francis, and L. Rita Rapid colorometric assay for cell growth and survival modifications to the tetrazolium dye procedure giving improved sensitivity and reliability J Immunol Methods 89 1986 271 277
7. 21-dependent apoptotic pathway in Human hepatoma cell lines Life Sci 71 2002 1879 1892
8. Shin Hwa Lee, Sumin Park, Suk Min Park, Jae Hyeon Park, Dong Yeok Shin, and Gi Young Kim Induction of apoptosis in Human leukemia U937 cells by anthocaynins through down-regulation of Bcl-2 and activation of caspases Int J Oncol 34 2009 1077 1083
9. L. Ojwang, and J.M. Awika Effect of pyruvic acid and ascorbic acid on stability of 3-deoxyanthocaynidins J Sci Food Agric 88 2008 1987 1996
10. M.S. Poei-Langston, and R.E. Wrolstad Color degradation in an ascorbic acid-anthocyanin-flavonol model system J Food Sci 46 1981 1218 1222
11. P. Suganyadevi, K.M. Saravanakumar, and S. Mohandas Evaluation of antiproliferative activity of red Sorghum brananhocyanin on a human breast cancer cell line (MCF-7) Int J Breast Cancer 2011 2011 4061