Increased plasma cell-free DNA is associated with low pregnancy rates among women undergoing IVF-embryo transfer

Reproductive BioMedicine Online

Volumn 26, Issue 1, 2013, Pages 36-41

  Czamanski Cohen, Johanna ^a   Sarid, Orly ^a,b   Cwikel, Julie ^b   Lunenfeld, Eitan ^a,b   Douvdevani, Amos ^b   Levitas, Eliahu ^a   Har Vardi, Iris ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Cell free DNA; IVF embryo transfer; Pregnancy rate

Indexed keywords

BIOLOGICAL MARKER; CELL FREE DNA; CHORIONIC GONADOTROPIN BETA SUBUNIT; DNA; HUMAN MENOPAUSAL GONADOTROPIN; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; TRIPTORELIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FETUS HEART RATE; FLUORESCENCE ANALYSIS; GESTATIONAL SAC; HORMONE BLOOD LEVEL; HUMAN; ISRAEL; MAJOR CLINICAL STUDY; NIDATION; OOCYTE RETRIEVAL; OVARY HYPERSTIMULATION; PLASMA CELL; PREGNANCY RATE; PROSPECTIVE STUDY; TRANSVAGINAL ECHOGRAPHY;

EID: 84874116815     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2012.09.018     Document Type: Article

References (31)

1. Arnalich, F., Maldifassi, M.C., Ciria, E., Quesada, A., Codoceo, R., Herruzo, R., Garcia-Cerrada, C., Montoya, F., Vazquez, J.J., López-Collazo, E., Montiel, C., 2010. Association of cell-free plasma DNA with perioperative mortality in patients with suspected acute mesenteric ischemia. Clin. Chim. Acta 411, 1269-1274.
2. Assou, S., Haouzi, D., De Vos, J., Hamamah, S., 2010. Human cumulus cells as biomarkers for embryo and pregnancy outcomes. Mol. Hum. Reprod. 16, 531-538.
3. Beck, J., Urnovitz, H.B., Riggert, J., Clerici, M., Schutz, E., 2009. Profile of the circulating DNA in apparently healthy individuals. Clin. Chem. 55, 730-738.
4. Bedaiwy, M.A., Mahfouz, R.Z., Goldberg, J.M., Sharma, R., Falcone, T., Abdel Hafez, M.F., Agarwal, A., 2010. Relationship of reactive oxygen species levels in day 3 culture media to the outcome of in vitro fertilization/ intracytoplasmic sperm injection cycles. Fertil. Steril. 94, 2037-2042.
5. Dean, A., Sullivan, K., Soe, M., 2010. OpenEpi: Open Source Epidemiologic Statistics for Public Health Version 2.3.1.
6. Destouni, A., Vrettou, C., Antonatos, D., Chouliaras, G., Traeger-Synodinos, J., Patsilinakos, S., Kitsiou-Tzeli, S., Tsigas, D., Kanavakis, E., 2009. Cell-free DNA levels in acute myocardial infarction patients during hospitalization. Acta Cardiol. 64, 51-57.
7. Díaz-Fontdevila, M., Pommer, R., Smith, R., 2009. Cumulus cell apoptosis changes with exposure to spermatozoa and pathologies involved in infertility. Fertil. Steril. 91, 2061-2068.
8. Gao, Y.J., He, Y.J., Yang, Z.L., Shao, H.Y., Zuo, Y., Bai, Y., Chen, H., Chen, X.C., Qin, F.X., Tan, S., Wang, J., Wang, L., Zhang, L., 2010. Increased integrity of circulating cell-free DNA in plasma of patients with acute leukemia. Clin. Chem. Lab. Med. 48, 1651-1656.
9. García Moreira, V., Prieto García, B., Baltar Martín, J.M., Ortega Suárez, F., Alvarez, F.V., 2009. Cell-free DNA as a noninvasive acute rejection marker in renal transplantation. Clin. Chem. 55, 1958-1966.
10. Goldshtein, H., Hausmann, M.J., Douvdevani, A., 2009. A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids. Ann. Clin. Biochem. 46, 488-494.
11. Hahn, S., Rusterholz, C., Hosli, I., Lapaire, O., 2011. Cell-free nucleic acids as potential markers for preeclampsia. Placenta 32, S17-S20.
12. Hart, E.A., Patton, W.C., Jacobson, J.D., King, A., Corselli, J., Chan, P.J., 2005. Luteal phase serum cell-free DNA as a marker of failed pregnancy after assisted reproductive technology. J. Assist. Reprod. Genet. 22, 213-217.
13. Jahr, S., Hentze, H., Englisch, S., Hardt, D., Fackelmayer, F.O., Hesch, R.-D., Knippers, R., 2001. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61, 1659-1665.
14. Jarkovska, K., Martinkova, J., Liskova, L., Halada, P., Moos, J., Rezabek, K., Gadher, S.J., Kovarova, H., 2010. Proteome mining of human follicular fluid reveals a crucial role of complement cascade and key biological pathways in women undergoing in vitro fertilization. J. Proteome Res. 9, 1289-1301.
15. Kamat, A.A., Baldwin, M., Urbauer, D., Dang, D., Han, L.Y., Godwin, A., Karlan, B.Y., Simpson, J.L., Gershenson, D.M., Coleman, R.L., Bischoff, F.Z., Sood, A.K., 2010. Plasma cell-free DNA in ovarian cancer. Cancer 116, 1918-1925.
16. Kang,H.-J., Feng, Z., Sun, Y., Atwal, G., Murphy, M.E., Rebbeck, T.R., Rosenwaks, Z., Levine, A.J., Hu, W., 2009. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc. Natl. Acad. Sci. USA 106, 9761-9766.
17. Katz-Jaffe, M.G., Mc Reynolds, S., 2011. Proteomic/metabolomic analysis of embryos: current status for use in Art. In: Racowsky, C., Schlegel, P.N., Fauser, B.C., Carrell, D.T. (Eds.), Biennial Review of Infertility. Springer, New York.
18. Lapaire, O., Volgmann, T., Huang, D., Hahn, S., Holzgreve, W., Xiao Zhong, Y., 2007. Maternal smoking: effect on circulating cell-free fetal and total DNA levels in maternal plasma from the second trimester. Obstet. Gynecol. 110, 1358-1363.
19. La'za'r, L., Nagy, B., Morvarec, A., Rigó, J., 2011. The correlation of circulating cell-free DNA, cell-free fetal DNA and microRNA 325 levels to clinical characteristics and laboratory parameters in pre-eclampsia. In: Gahan, P.B. (Ed.), Circulating Nucleic Acids in Plasma and Serum. Springer, Netherlands.
20. Liu, J., Li, Y., 2010. [Effect of oxidative stress and apoptosis in granulosa cells on the outcome of IVF-ET]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 35, 990-994.
21. Polcher, M., Ellinger, J., Willems, S., El-Maarri, O., Holler, T., Amann, C., 2010. Impact of the menstrual cycle on circulating cell-free DNA. Anticancer Res. 30, 2235-2240.
22. Razieh Dehghani, F., Nasrin, G., Maryam Ayazi, R., Nasim, T., 2009. Association of p53 polymorphism with ICSI/IVF failure and recurrent pregnancy loss. Aust. N. Z. J. Obstet. Gynaecol. 49, 216-219.
23. Seli, E., Robert, C., Sirard, M.-A., 2010. OMICS in assisted reproduction: possibilities and pitfalls. Mol. Hum. Reprod. 16, 513-530.
24. Shimony, A., Zahger, D., Gilutz, H., Goldstein, H., Orlov, G., Merkin, M., Shalev, A., Ilia, R., Douvdevani, A., 2010. Cell free DNA detected by a novel method in acute ST-elevation myocardial infarction patients. Acute Card. Care 12, 109-111.
25. Suzuki, N., Kamataki, A., Yamaki, J., Homma, Y., 2008. Characterization of circulating DNA in healthy human plasma. Clin. Chim. Acta 387, 55-58.
26. Thouas, G.A., Gardner, D.K., 2010. Metabolomic profiling for selection of the most viable embryos in clinical IVF. Curr. Womens Health Rev. 6, 254-260.
27. Tokuhisa, Y., Iizuka, N., Sakaida, I., Moribe, T., Fujita, N., Miura, T., Tamatsukuri, S., Ishitsuka, H., Uchida, K., Terai, S., Sakamoto, K., Tamesa, T., Oka, M., 2007. Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma. Br. J. Cancer 97, 1399-1403.
28. Urato, A.C., Peter, I., Canick, J., Lambert-Messerlian, G., Pulkkinen, A., Knight, G., Jeong, Y.J., Johnson, K.L., Bianchi, D.W., 2008. Smoking in pregnancy is associated with increased total maternal serum cell-free DNA levels. Prenat. Diagn. 28, 186-190.
29. Vodicka, R., Bohmova, J., Dhaifalah, I., Blumenthalova, J., Kratochvilova, R., Santavy, J., Prochazka, M., Vrtel, R., 2010. Analysis of cell free fetal DNA fragmentation rate in pregnant women during the course of gravidit. Ceska Gynekol. 75, 312-316.
30. Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., Oren, M., 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352, 345-347.
31. Zhang, R., Shao, F., Wu, X., Ying, K., 2010. Value of quantitative analysis of circulating cell free DNA as a screening tool for lung cancer: a meta-analysis. Lung Cancer 69, 225-231.