Screening of differentially expressed genes and small molecule drugs of pediatric allergic asthma with DNA microarray

European Review for Medical and Pharmacological Sciences

Volumn 16, Issue 14, 2012, Pages 1961-1966

  Wang, X Q ^a   Wang, X M ^b   Zhou, T F ^a   Dong, L Q ^a  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU WOMEN S AND CHILDREN S CENTRAL HOSPITAL   (China)

Author keywords

Co expression network; Differentially expressed gene; Functional annotation; Pediatric allergic asthma

Indexed keywords

3 NITROPROPIONIC ACID; 6 (1,3 DIOXO 1H,3H BENZO[DE]ISOQUINOLIN 2 YL) N HYDROXYHEXANAMIDE; ACONITASE 1; ACONITATE HYDRATASE; AMINOLEVULINATE DELTA SYNTHASE 1; EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 DELTA; FELBINAC; GLUTATHIONE PEROXIDASE 3; INITIATION FACTOR; INITIATION FACTOR 5A; INITIATION FACTOR 5B; IODIXANOL; JOSAMYCIN; OXOLAMINE; PENBUTOLOL; PHOSPHOGLUCONATE DEHYDROGENASE; RIBOSOME PROTEIN; SANGUINARINE; SYNTHETASE; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ARTICLE; CHILDHOOD DISEASE; DNA MICROARRAY; DOWN REGULATION; DRUG DESIGN; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC DATABASE; HUMAN; NUCLEOTIDE SEQUENCE; UPREGULATION;

ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ASTHMA; CASE-CONTROL STUDIES; DATABASES, GENETIC; DRUG DISCOVERY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; HYPERSENSITIVITY; MOLECULAR TARGETED THERAPY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 84874100891     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. VERCELLI D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008; 8: 169-182.
2. WU H, ROMIEU I, SHI M., HANCOCK DB, LI H, SIENRA-MONGE JJ, CHIU G Y, XU H, DEL RIO-NAVARRO BE, LONDON SJ. Evaluation of candidate genes in a genome-wide association study of childhood asthma in mexicans. J Allergy Clin Immunol 2010; 125: 321-327. e313.
3. DOCHERTY SJ, BUTCHER LM, SCHALKWYK L.C., PLOMIN R. Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics 2007; 8: 214.
4. VIDING E, HANSCOMBE KB, CURTIS C.J., DAVIS OS, MEABURN EL, PLOMIN R. In search of genes associated with risk for psychopathic tendencies in children: A two-stage genome-wide association study of pooled DNA. J Child Psychol Psychiatry 2010; 51: 780-788.
5. MEDINA I, MONTANER D, BONIFACI N., PUJANA MA, CARBONELL J, TARRAGA J, AL-SHAHROUR F, DOPAZO J. Gene set-based analysis of polymorphisms: Finding pathways or biological processes associated to traits in genome-wide association studies. Nucleic Acids Res 2009; 37: W340-344.
6. KICIC A, HALLSTRAND TS, SUTANTO E.N., STEVENS PT, KOBOR MS, TAPLIN C, PARE P.D., BEYER R P, STICK SM, KNIGHT DA Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. Am J Respir Crit Care Med 2010; 181: 889-898.
7. FUJITA A, SATO JR, RODRIGUES LDE O, FERREIRA CE, SOGAYAR MC Evaluating different methods of microarray data normalization. BMC Bioinformatics 2006; 7: 469.
8. SZKLARCZYK D, FRANCESCHINI A, KUHN M., SIMONOVIC M, ROTH A, MINGUEZ P., DOERKS T, STARK M, MULLER J., BORK P, JENSEN LJ, VON MERING C. The string database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 2011; 39: D561-568.
9. HUANG DA W., SHERMAN BT, LEMPICKI RA Systematic and integrative analysis of large gene lists using david bioinformatics resources. Nat Protoc 2009; 4: 44-57.
10. BERRIZ G.F., BEAVER JE, CENIK C, TASAN M., ROTH FP Next generation software for functional trend analysis. Bioinformatics 2009; 25: 3043-3044.
11. YAMAYA M. Virus infection-induced bronchial asthma exacerbation. Pulmonary Med 2012; 2012.
12. BUSSE WW, LEMANSKE JR RF, GERN JE. The role of viral respiratory infections in asthma and asthma exacerbations. Lancet 2010; 376: 826.
13. Simon-Nobbe B., Denk U, Pöll V, Rid R., Breitenbach M. The spectrum of fungal allergy. Int Arch Allergy Immunol 2008; 145: 58-86.
14. YASUDA H, SUZUKI T, ZAYASU K., ISHIZUKA S, KUBO H, SASAKI T., NISHIMURA H, SEKIZAWA K, YAMAYA M. Inflammatory and bronchospastic factors in asthma exacerbations caused by upper respiratory tract infections. Tohoku J Exp Med 2005; 207: 109-118.
15. NADEEM A, CHHABRA SK, MASOOD A, RAJ HG Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol 2003; 111: 72-78.
16. MISSO N, POWERS K, GILLON R., STEWART G, THOMPSON P. Reduced platelet glutathione peroxidase activity and serum selenium concentration in atopic asthmatic patients. Clin Exp Allergy 2006; 26: 838-847.
17. MAK JCW, CHAN-YEUNG MMW. Reactive oxidant species in asthma. Curr Opin Pulm Med 2006; 12: 7-11.
18. AHUJA-JENSEN P., JOHNSEN-SORIANO S, AHUJA S., BOSCHMORELL F, SANCHO-TELLO M, ROMERO FJ, ABRAHAMSON M, VAN VEEN T. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 2007; 18: 797-801.
19. JENSEN GE, GISSEL-NIELSEN G, CLAUSEN J. Leucocyte glutathione peroxidase activity and selenium level in multiple sclerosis. J Neurol Sci 1980; 48: 61-67.
20. DEVEREUX G, SEATON A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 2005; 115: 1109-1117.
21. HEINRICH J. Air pollution, asthma and allergies in children. Occup Environ Med 2010; 67: 290-291.
22. Bošnjak-Petrović V. Drug induced asthma. Acta Clinica 2007; 7: 43-50.
23. SHORT PM, WILLIAMSON PA, LIPWORTH BJ Effects of hydrocortisone on acute beta-adrenoceptor blocker and histamine induced bronchoconstriction. Br J Clin Pharmacol 2012; 73: 717-726.
24. MATSUNO O, UENO K, HAYAMA Y., HONDA H, YAMANE H, SAEKI Y. Deterioration of asthma in a patient with diffuse panbronchiolitis (DPB) after macrolide therapy. J Asthma 2010; 47: 486-488.
25. GONCHAROVA E, GONCHAROV D, ZHAO H., PENN R, KRYMSKAYA V, PANETTIERI JR R. beta2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein. Am J Resp Cell Mol Biol 2012; 46: 48-54.
26. SINGH D, PETAVY F, MACDONALD A.J., LAZAAR AL, O'CONNOR BJ. The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma. Respir Res 2010; 11: 26
27. AICH J, MABALIRAJAN U, AHMAD T., KHANNA K, REHMAN R, AGRAWAL A., GHOSH B. Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A). Int Immunopharmacol 2012; 14: 438-443.
28. XU J, MENG Q, CHONG Y., JIAO Y, ZHAO L, ROSEN E., FAN S. Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis. Oncol Rep 2012; 28: 2264-2270.
29. NIU X, FAN T, LI W., XING W, HUANG H. The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages. Eur J Pharmacol 2012; 689: 262-269.