In vitro pulsatility analysis of axial-flow and centrifugal-flow left ventricular assist devices

Journal of Biomechanical Engineering

Volumn 135, Issue 3, 2013, Pages

  Stanfield, J Ryan ^a   Selzman, Craig H ^b  

^a University of Utah   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

axial flow blood pump; centrifugal flow blood pump; left ventricular assist device; mechanical circulatory support; pulsatility

Indexed keywords

AXIAL FLOW BLOOD PUMPS; AXIAL FLOW PUMP; AXIAL PUMPS; BLOOD PUMP; CIRCULATORY FLOW; CONTINUOUS-FLOW; HEART FAILURE; IMPELLER SPEED; IN-VITRO; MECHANICAL CIRCULATORY SUPPORT; PULSATILITY; PULSATILITY INDEX; VENTRICULAR ASSIST DEVICE;

BLOOD; CENTRIFUGAL PUMPS; LEFT VENTRICULAR ASSIST DEVICES; PUMPS;

CENTRIFUGATION;

ACCURACY; ARTICLE; AXIAL FLOW LEFT VENTRICULAR ASSIST DEVICE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BLOOD PUMP; CENTRIFUGAL FLOW LEFT VENTRICULAR ASSIST DEVICE; CENTRIFUGAL PUMP; CIRCULATION; CONTROLLED STUDY; HEART INDEX; HEART VENTRICLE; HUMAN; HYPERTENSION; HYPOTENSION; IN VITRO STUDY; LEFT VENTRICULAR ASSIST DEVICE; PULSATILE FLOW; PULSATILITY INDEX; ANIMAL; CENTRIFUGATION; HEART ASSIST DEVICE; HYDRODYNAMICS; PATHOPHYSIOLOGY; SWINE;

ANIMALS; BLOOD PRESSURE; CENTRIFUGATION; HEART VENTRICLES; HEART-ASSIST DEVICES; HYDRODYNAMICS; HYPERTENSION; SWINE;

EID: 84874093927     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4023525     Document Type: Article

References (27)

1. Wesolowski, S. A., Fisher, J. H., and Welsh, C. S., 1953, " Perfusion of the Pulmonary Circulation by Nonpulsatile Flow.," Surgery, 33 (3), pp. 370-375.
2. Nose, Y., 1992, " Is a Pulsatile Cardiac Prosthesis a Dying Dinosaur? " Artif. Organs, 16 (3), pp. 233-234.
3. Hindman, B. J., Dexter, F., Ryu, K. H., Smith, T., and Cutkomp, J., 1994, " Pulsatile versus Nonpulsatile Cardiopulmonary Bypass: No Difference in Brain Blood Flow or Metabolism at 27 °C.," Anesthesiology, 80 (5), pp. 1137-1147, Available at: http://journals.lww.com/anesthesiology/Abstract/1994/ 05000/Pulsatile-Versus-Nonpulsatile-Cardiopulmonary.23.aspx
4. Pagani, F. D., Miller, L. W., Russell, S. D., Aaronson, K. D., John, R., Boyle, A. J., Conte, J. V., Bogaev, R. C., MacGillivray, T. E., Naka, Y., Mancini, D., Massey, H. T., Chen, L., Klodell, C. T., Aranda, J. M., Moazami, N., Ewald, G. A., Farrar, D. J., and Frazier, O. H., 2009, " Extended Mechanical Circulatory Support With a Continuous-Flow Rotary LVAD.," J. Am. Coll. Cardiol., 54 (4), pp. 312-321.
5. Slaughter, M. S., Rogers, J. G., Milano, C. A., Russell, S. D., Conte, J. V., Feldman, D., Sun, B., Tatooles, A. J., Delgado, R. M., Long, J. W., Wozniak, T. C., Ghumman, W., Farrar, D. J., and Frazier, O. H., 2009, " Advanced Heart Failure Treated With Continuous-Flow LVAD.," New Engl. J. Med., 361, pp. 2241-2251.
6. Nose, Y., 1988, " The Need for a Nonpulsatile Pumping System.," Artif. Organs, 12 (2), pp. 113-115.
7. Unger, F., 1986, " Review Article: Current Status and Use of Artificial Hearts and Circulatory Assist Devices.," Perfusion, 1 (3), pp. 155-163.
8. Olsen, D. B., 2000, " The History of Continuous-Flow Blood Pumps.," Artif. Organs, 24 (6), pp. 401-404.
9. Allen, G. S., Murray, K. D., and Olsen, D. B., 1997, " The Importance of Pulsatile and Nonpulsatile Flow in the Design of Blood Pumps.," Artif. Organs, 21 (8), pp. 922-928.
10. Potapov, E. V., Loebe, M., Nasseri, B. A., Sinawski, H., Koster, A., Kuppe, H., Noon, G. P., DeBakey, M. E., and Hetzer, R., 2000, " Pulsatile Flow in Patients With a Novel Nonpulsatile Implantable VAD.," Circulation, 102 (19 Suppl. 3), pp. III183-III187.
11. Griffith, B. P., Kormos, R. L., Borovetz, H. S., Litwak, K., Antaki, J. F., Poirier, V. L., and Butler, K. C., 2001, " HeartMate II LVAS: From Concept to First Clinical Use.," Ann. Thorac. Surg., 71 (3 Suppl.), pp. S116-S120.
12. Choi, S., Antaki, J. F., Boston, J. R., and Thomas, D. A., 2001, " Sensorless Approach to Control of a Turbodynamic LVAS.," IEEE T. Contr. Syst. T., 9 (3), pp. 473-482.
13. Pantalos, G. M., Koenig, S. C., Gillars, K. J., Giridharan, G. A., and Ewert, D. L., 2004, " Characterization of an Adult Mock Circulation for Testing Cardiac Support Devices.," ASAIO J., 50 (1), pp. 37-46.
14. Stanfield, J. R., Selzman, C. H., Pardyjak, E. R., and Bamberg, S. M., 2012, " Flow Characteristics of Continuous-Flow LVADs in a Novel Open-Loop System.," ASAIO J., 58 (6), pp. 590-596.
15. Stanfield, J. R., and Selzman, C. H., 2012, " Pressure Sensitivity of Axial-Flow and Centrifugal-Flow LVADs.," Cardiovasc. Eng. Tech., 3 (4), pp. 413-423.
16. Choi, S., Boston, J. R., and Antaki, J. F., 2005, " An Investigation of the Pump Operating Characteristics as a Novel Control Index for LVAD Control.," Int. J. Cont. Autom., 3 (1), pp. 100-108, Available at: http://bme2.aut.ac.ir/~towhidkhah/BioModelling/Seminar87-1/rohani/ An%20investigation%20of%20the%20pump%20operating%20characteristics%20as%20a%20n ovel%20control%20index%20for%20LVAD%20control.pdf
17. Choi, S., Boston, J. R., and Antaki, J. F., 2007, " Hemodynamic Controller for LVAD Based on Pulsatility Ratio.," Artif. Organs, 31 (2), pp. 114-125.
18. Stepanoff, A. J., 2011, Centrifugal and Axial Flow Pumps, 2nd ed., John Wiley Sons, New York.
19. Garcia, S., Kandar, F., Boyle, A., Colvin-Adams, M., Lliao, K., Joyce, L., and John, R., 2008, " Effects of Pulsatile-and Continuous-Flow LVADs on Left Ventricular Unloading.," J. Heart Lung Transpl., 27 (3), pp. 261-267.
20. Klotz, S., Deng, M. C., Stypmann, J., Roetker, J., Wilhelm, M. J., Hammel, D., Scheld, H., H., and Schmid, C., 2004, " Left Ventricular Pressure and Volume Unloading During Pulsatile versus Nonpulsatile LVAD Support.," Ann. Thorac. Surg., 77 (1), pp. 143-150.
21. Haft, J., Armstrong, W., Dyke, D. B., Aaronson, K. D., Koelling, T. M., Farrar, D. J., and Pagani, F. D., 2007, " Hemodynamic and Exercise Performance With Pulsatile and Continuous-Flow LVADs.," Circulation, 116 (11 Suppl.), pp. I8-I15.
22. DiGiorgi, P. L., Smith, D. L., Naka, Y., and Oz, M. C., 2004, " In Vitro Characterization of Aortic Retrograde and Antegrade Flow From Pulsatile and Nonpulsatile VADs.," J. Heart Lung Transpl., 23 (2), pp. 186-192.
23. Nakata, K., Shiono, M., Orime, Y., Hata, M., Sezai, A., Saitoh, T., and Sezai, Y., 1996, " Effect of Pulsatile and Nonpulsatile Assist on Heart and Kidney Microcirculation With Cardiogenic Shock.," Artif. Organs, 20 (6), pp. 681-684.
24. Amir, O., Radovancevic, B., Delgado, R. M., Kar, B., Radovancevic, R., Henderson, M., Cohn, W. E., and Smart, F. W., 2006, " Peripheral Vascular Reactivity in Patients With Pulsatile vs. Axial Flow LVAD Support.," J. Heart Lung Transpl., 25 (4), pp. 391-394.
25. Young, J. B., 2001, " Healing the Heart With VAD Therapy: Mechanisms of Cardiac Recovery." Ann. Thorac. Surg., 71 (3 Suppl.), pp. S210-S219.
26. Levin, H., Oz, M., Chen, J., Packer, M., Rose, E., and Burkhoff, D., 1995, " Reversal of Chronic Ventricular Dilatation in Patients With End-Stage Cardiomyopathy by Prolonged Mechanical Unloading.," Circulation, 91 (11), pp. 2717-2720.
27. Farrar, D. J., Bourque, K., Dague, C. P., Cotter, C. J., and Poirier, V. L., 2007, " Design Features, Developmental Status and Experimental Results With the Heartmate III Centrifugal LVAS With Magnetically Levitated Rotor.," ASAIO J., 53 (3), pp. 310-315.