The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 3, 2013, Pages 1552-1555

  Fursova, N ^a   Pryamchuk, S ^a   Kruglov, A ^b   Abaev, I ^a   Pecherskikh, E ^a   Kartsev, N ^a   Svetoch, E ^a   Dyatlov, I ^a  

^a STATE RESEARCH CENTER FOR APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   (Russian Federation)

^b National Agency for Clinical Pharmacology and Pharmacy   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BETA LACTAMASE CTX M; BETA LACTAMASE CTX M 116; BETA LACTAMASE CTX M 22; BETA LACTAMASE CTX M 23; NUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; DATA BASE; DNA SEQUENCE; GENE IDENTIFICATION; GENETIC RECOMBINATION; HOSPITAL INFECTION; HYBRID GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEUS MIRABILIS; RETROSPECTIVE STUDY; SEQUENCE ANALYSIS;

BASE SEQUENCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BETA-LACTAMS; CROSS INFECTION; DATABASES, NUCLEIC ACID; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEUS INFECTIONS; PROTEUS MIRABILIS; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 84874079461     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01471-12     Document Type: Article

References (26)

1. Bonnet R. 2004. Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. Antimicrob. Agents Chemother. 48:1-14.
2. Eckert C, Gautier V, Saladin-Allard M, Hidri N, Verdet C, Ould-Hocine Z, Barnaud G, Delisle F, Rossier A, Lambert T, Philippon A, Arlet G. 2004. Dissemination of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Paris, France. Antimicrob. Agents Chemother. 48:1249 -1255.
3. Livermore DM, Canton R, Gniadkowski M, Nordmann P, Rossolini GM, Arlet G, Ayala J, Coque TM, Kern-Zdanowicz I, Luzzaro F, Poirel L, Woodford N. 2007. CTX-M: changing the face of ESBLs in Europe. J. Antimicrob. Chemother. 59:165-174.
4. Bonnet R, Dutour C, Sampaio JLM, Chanal C, Sirot D, Labia R, DeChamps C, Sirot J. 2001. Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240¡Gly. Antimicrob. Agents Chemother. 45:2269 -2275.
5. Bush K, Fisher JF. 2011. Epidemiological expansion, structural studies and clinical challenges of new beta-lactamases from gram-negative bacteria. Annu. Rev. Microbiol. 65:455- 478.
6. Cantón R, Coque TM. 2006. The CTX-M beta-lactamase pandemic. Curr. Opin. Microbiol. 9:466-475.
7. Partridge SR. 2011. Analysis of antibiotic resistance regions in Gramnegative bacteria. FEMS Microbiol. Rev. 35:820-855.
8. Pfeifer Y, Cullik A, Witte W. 2010. Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens. Int. J. Med. Microbiol. 300:371-379.
9. Poirel L, Lartigue MF, Decousser JW, Nordmann P. 2005. ISEcp1Bmediated transposition of blaCTX-M in Escherichia coli. Antimicrob. Agents Chemother. 49:447- 450.
10. Novais A, Comas I, Baquero F, Cantón R, Coque TM, Moya A, González-Candelas F, Galán JC. 2010. Evolutionary trajectories of betalactamase CTX-M-1 cluster enzymes: predicting antibiotic resistance. PLoS Pathog. 6:e1000735. doi:10.1371/journal.ppat.1000735.
11. Nagano Y, Nagano N, Wachino J, Ishikawa K, Arakawa Y. 2009. Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. Antimicrob. Agents Chemother. 53:69 -74.
12. Pryamchuk SD, Fursova NK, Abaev IV, Kovalev YN, Shishkova NA, Pecherskikh EI, Korobova OV, Astashkin EI, Pachkunov DM, Kruglov AN, Ivanov DV, Sidorenko SV, Svetoch EA, Dyatlov IA. 2010. Genetic determinants of antibacterial resistance among nosocomial Escherichia coli, Klebsiella spp., and Enterobacter spp. isolates collected in Russia on 2003-2007. Antibiot. Chemother. 55(9 -10):3-10. (In Russian.).
13. NCCLS/CLSI. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 5th ed. Document M7-A5. Clinical and Laboratory Standards Institute, Wayne, PA.
14. Edelstein M, Pimkin M, Palagin I, Edelstein I, Stratchounski L. 2003. Prevalence and molecular epidemiology of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals. Antimicrob. Agents Chemother. 47:3724 -3732.
15. Jiang X, Ni Y, Jiang Y, Yuan F, Han L, Li M, Liu H, Yang L, Lu Y. 2005. Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China. J. Clin. Microbiol. 43:826-831.
16. Machado E, Cantón R, Baquero F, Galán JC, Rollán A, Peixe L, Coque TM. 2005. Integron content of extended-spectrum-beta- lactamaseproducing Escherichia coli strains over 12 years in a single hospital in Madrid, Spain. Antimicrob. Agents Chemother. 49:1823-1829.
17. Oliver A, Weigel LM, Rasheed JK, McGowan JE Jr, Raney P, Tenover FC. 2002. Mechanisms of decreased susceptibility to cefpodoxime in Escherichia coli. Antimicrob. Agents Chemother. 46:3829 -3836.
18. Rasheed JK, Jay C, Metchock B, Berkowitz F, Weigel L, Crellin J, Steward C, Hill B, Medeiros AA, Tenover FC. 1997. Evolution of extended- spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia. Antimicrob. Agents Chemother. 41:647- 653.
19. Skurnik D, LeMenac'h A, Zurakowski D, Mazel D, Courvalin P, Denamur E, Andremont A, Ruimy R. 2005. Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli isolates from healthy subjects free of recent antibiotic exposure. Antimicrob. Agents Chemother. 49:3062-3065.
20. Fursova NK, Pryamchuk SD, Abaev IV, Kovalev YN, Shishkova NA, Pecherskikh EI, Korobova OV, Astashkin EI, Pachkunov DM, Svetoch EA, Sidorenko SV. 2010. Genetic environments of blaCTX-M genes located on conjugative plasmids of Enterobacteriaceae nosocomial isolates collected in Russia within 2003-2007. Antibiot. Khimioter. 55(11-12):3-10. (In Russian.).
21. Pryamchuk SD, Fursova NK, Anisimova VA, Kovalev YN, Abaev IV, Kuzhelnaya EN, Svetoch EA. 2011. An algorithm for identification of CTX-M-type beta-lactamase genes using restriction fragment length polymorphism analysis of PCR-product. Mol. Gen. Mikrobiol. Virusol. 2011(4):7-13. (In Russian.).
22. Stürenburg E, Kühn A, Mack D, Laufs R. 2004. A novel extendedspectrum beta-lactamase CTX-M-23 with a P167T substitution in the active- site omega loop associated with ceftazidime resistance. J. Antimicrob. Chemother. 54:406-409.
23. Liu G, Ling BD, Xie YE, Lin L, Zeng Y, Zhang X, Lei J. 2007. Characterization of CTX-M-22 and TEM-141 encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China. Jpn. J. Infect. Dis. 60: 295-297.
24. Tian SF, Chen BY, Chu YZ, Wang S. 2008. Prevalence of rectal carriage of extended-spectrum beta-lactamase-producing Escherichia coli among elderly people in community settings in China. Can. J. Microbiol. 54:781-785.
25. Sun Y, Zeng Z, Chen S, Ma J, He L, Liu Y, Deng Y, Lei T, Zhao J, Liu J-H. 2010. High prevalence of blaCTX-M extended-spectrum betalactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China. Clin. Microbiol. Infect. 16:1475-1481.
26. Ambler RP, Coulson AF, Frere JM, Ghuysen JM, Joris B, Forsman M, Levesque RC, Tiraby G, Waley SG. 1991. A standard numbering scheme for the class A beta-lactamases. Biochem. J. 276(Pt 1):269 -270.