Highly sensitive detection of EGFR T790M mutation in Pre-TKI specimens of EGFR-mutated NSCLC: In cis, in trans, or a different clone?

Journal of Thoracic Oncology

Volumn 8, Issue 3, 2013, Pages

  Leone, Alvaro ^a  

^a SAN CAMILLO FORLANINI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE INHIBITOR; VASCULOTROPIN RECEPTOR;

ALLELE; CANCER PATIENT; CANCER PROGNOSIS; CANCER THERAPY; DIAGNOSTIC ACCURACY; DISEASE ACTIVITY; GENE EXPRESSION; GENE MUTATION; HETEROZYGOTE; HUMAN; LETTER; LUNG NON SMALL CELL CANCER; MOLECULAR CLONING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 84874065423     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31827e2467     Document Type: Letter

References (5)

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2. O xnard GR, Arcila ME, Sima CS, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res 2011;17: 1616-1622.
3. R osell R, Molina MA, Costa C, et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res 2011;17: 1160-1168.
4. Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-smallcell lung cancer to gefitinib. N Engl J Med 2005;352: 786-792.
5. Miyazawa H, Tanaka T, Nagai Y, et al.; Huqun. Peptide nucleic acid-locked nucleic acid polymerase chain reaction clampbased detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation. Cancer Sci 2008;99: 595-600.