Antiviral therapy for HCV-associated cryoglobulinemic glomerulonephritis: Case report and review of the literature

Kidney and Blood Pressure Research

Volumn 35, Issue 6, 2012, Pages 687-693

  Fabrizi, Fabrizio ^a   Fogazzi, Giovanni Battista ^a   Cresseri, Donata ^a   Passerini, Patrizia ^a   Martin, Paul ^b   Donato, Maria Francesca ^a   Rumi, Maria Grazia ^a   Messa, Piergiorgio ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Cryoglobulinemia; Glomerulonephritis; Hepatitis C; Interferon; Rituximab

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINUCLEAR ANTIBODY; ASPARTATE AMINOTRANSFERASE; CHLOROQUINE; CORTICOSTEROID; CREATININE; CRYOGLOBULIN; GAMMA GLUTAMYLTRANSFERASE; IMMUNOGLOBULIN M; METHOTREXATE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PEGINTERFERON ALPHA2A; PREDNISONE; RIBAVIRIN; RITUXIMAB;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANTIVIRAL THERAPY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; CREATININE BLOOD LEVEL; CRYOGLOBULINEMIA; DRUG EFFICACY; DRUG SAFETY; DUODENAL ULCER BLEEDING; DUODENUM ULCER; ELECTROMYOGRAPHY; ELECTROPHORESIS; ENDOSCOPY; ERYTHROCYTE TRANSFUSION; FEMALE; FIBROSING ALVEOLITIS; GLOMERULONEPHRITIS; HEMATURIA; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HYPERTENSION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FUNCTION; LEG EDEMA; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; NEPHROSCLEROSIS; NEUROPATHY; PRIORITY JOURNAL; PROTEINURIA; PURPURA; REMISSION; REVIEW; TREATMENT RESPONSE; URINE SEDIMENT;

EID: 84874044422     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000345515     Document Type: Review

References (44)

1. Lauer G, Walker B: Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52.
2. Pascual M, Perrin L, Giostra E, Schifer J: Hepatitis C virus in patients with cryoglobulinemia type II. J Infect Dis 1990; 162: 567-569.
3. Ferri C, Greco F, Longombardo G, Palla P, Moretti A, Marzo E, Foselle P, Pasero G, Bombardieri S: Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. Arthritis Rheum 1991; 34: 1606-1610.
4. Agnello V, Chung R, Kaplan L: A role of hepatitis C infection in type II cryoglobulinemia. N Engl J Med 1992; 327: 1490-1495.
5. Fabrizi F, Colucci P, Ponticelli C, Locatelli F: Kidney and liver involvement in cryoglobulinemia. Semin Nephrol 2002; 22: 309-318.
6. Johnson R, Willson R, Yamabe H, Couser W, Alpers C, Wener M, Davis C, Gretch D: Renal manifestations of hepatitis C virus infection. Kidney Int 1994; 46: 1255-1263.
7. D'Amico G: Renal involvement in hepatitis C infection: Cryoglobulinemic glomerulonephritis. Kidney Int 1998; 54: 650-671.
8. Kasuno K, Ono T, Matsumori A, Nogaki F, Kusano H, Watanabe H, Yodoi J, Muso E: Hepatitis C virus associated tubulo-interstitial injury. Am J Kidney Dis 2003; 41: 767-775.
9. Kidney Disease: Improving Global Outcomes. KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int 2008; 73(suppl 109):S1-S99.
10. Roccatello D, Baldovino S, Rossi D, Mansouri M, Naretto C, Gennaro M, Cavallo R, Alper M, Costanzo P, Giachino O, Mazzucco G, Sena L: Long-term effects of anti-CD20 monoclonal antibody treatment of cryoglobulinaemic glomerulonephritis. Nephrol Dial Transplant 2004; 19: 3054-3061.
11. Garini G, Allegri L, Carnevali L, et al: Interferon alfa in combination with ribavirin as initial treatment for hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis. Am J Kidney Dis 2001; 38:E35-E39.
12. Johnson R, Gretch D, Couser W, Alpers C, Willson J, Chung M, Hart J, Willson R: Hepatitis C virus-associated glomerulonephritis. Effect of alpha-interferon therapy. Kidney Int 1994; 46: 1700-1704.
13. Stehman-Breen C, Alpers C, Couser W, Willson R, Johnson R: Hepatitis C virus associated membranous glomerulonephritis. Clin Nephrol 1995; 44: 141-147.
14. Fabrizi F, Pozzi C, Farina M, Dattolo P, Lunghi G, Badalamenti S, Pagano A, Locatelli F: Hepatitis C virus infection and acute or chronic glomerulonephritis: An epidemiological and clinical appraisal. Nephrol Dial Transplant 1998; 13: 1991-1997.
15. Komatsuda A, Imai H, Wakui H, Hamai K, Ohtani H, Kodama T, Oyama Y, Nakamoto Y: Clinicopathological analysis and therapy in hepatitis C virus-associated nephropathy. Intern Med 1996; 35: 529-533.
16. Al-Wakeel J, Mitwalli A, Tarif N, Al-Mohaya S, Malik G, Khalil M: Role of interferon-alpha in the treatment of primary glomerulonephritis. Am J Kidney Dis 1999; 33: 1142-1146.
17. Beddhu S, Bastacky S, Johnson J: The clinical and morphologic spectrum of renal cryoglobulinemia. Medicine (Baltimore) 2002; 81: 398-409.
18. Colucci G, Manno C, Grandaliano G, Schena FP: Cryoglobulinemic membrano-proliferative glomerulonephritis: Beyond conventional therapy. Clin Nephrol 2011; 75: 374-379.
19. Mazzaro C, Panarello G, Carniello S, Faelli A, Mazzi G, Crovatto M, Baracetti S, Nascimbeni F, Zorat F, Pozzato G, Faccini L, Campanacci L: Interferon versus steroids in patients with hepatitis C virus-associated glomerulonephritis. Digest Liver Dis 2000; 32: 708-715.
20. Bruchfeld A, Lindahl K, Stahle L, Soderberg M, Schvarcz R: Interferon and ribavirin treatment in patients with hepatitis C-associated renal disease and renal insufficiency. Nephrol Dial Transplant 2003; 18: 1573-1580.
21. Rossi P, Bertani T, Baio P, Caldara R, Luliri P, Tengattini F, Bellavita P, Mazzucco G, Misiani R: Hepatitis C virus-related cryoglobulinemic glomerulonephritis: Long-term remission after antiviral therapy. Kidney Int 2003; 63: 2236-2241.
22. Alric L, Plaisier E, Thébault S, Péron JM, Rostaing L, Pourrat J, Ronco P, Piette JC, Cacoub P: Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN. Am J Kidney Dis 2004; 43: 617-623.
23. Saadoun D, Resche-Rigon M, Thibault V, Piette J, Cacoub P: Antiviral therapy for hepatitis C-associated mixed cryoglobulinemia vasculitis. Arthritis Rheum 2006; 54: 3696-3706.
24. Garini G, Allegri L, Iannuzzella F, Vaglio A, Buzio C: HCV-related cryoglobulinemic glomerulonephritis: Implications of antiviral and immunosuppressive terapies. Acta Biomed 2007; 78: 51-59.
25. Roccatello D, Fornasieri A, Giachino O, Rossi D, Beltrame A, Banfi G, Confalonieri R, Tarantino A, Pasquali S, Amoroso A, Savoldi S, Colombo V, Manno C, Ponzetto A, Moriconi L, Pani A, Rustichelli R, Barbiano di Belgiojoso G, Comotti C, Quarenghi M: Multicenter study on hepatitis C virus-related cryoglobulinemic glomerulonephritis. Am J Kidney Dis 2007; 49: 69-82.
26. Abbas G, Hussain S, Shafi T: Effect of antiviral therapy on hepatitis C virus related glomerulopathy. Saudi J Kidney Dis Transplant 2008; 19: 775-780.
27. Saadoun D, Resche Rigon M, Sene D, Terrier B, Karras A, Perard L, Schoindre Y, Coppéré B, Blanc F, Musset L, Piette JC, Rosenzwajg M, Cacoub P: Rituximab plus Peg-interferon-alpha/ribavirin compared with Peg-interferon-alpha/ribavirin in hepatitis C-related mixed cryoglobulinemia. Blood 2010; 116: 326-334.
28. Quartuccio L, Soardo G, Romano G, Zaja F, Scott C, De Marchi G, Fabris M, Ferraccioli G, De Vita S: Rituximab treatment for glomerulonephritis in HCV-associated mixed cryoglobulinemia: Efficacy and safety in the absence of steroids. Rheumatology 2006; 45: 842-846.
29. Petrarca A, Rigacci L, Monti M, Giannini C, Bernardi F, Caini P, Colagrande S, Bosi A, Laffi G, Zignego AL: Improvement in liver cirrhosis after treatment of HCV-related mixed cryoglobulinemia with rituximab. Dig Liver Dis 2007; 39(suppl 1):S129-S133.
30. Roccatello D, Baldovino S, Rossi D, Giachino O, Mansouri M, Naretto C, Di Simone D, Francica S, Cavallo R, Alpa M, Napoli F, Sena L: Rituximab as a therapeutic tool in severe mixed cryoglobulinemia. Clin Rev Allergy Immunol 2008; 34: 111-117.
31. Saadoun D, Mesche-Rigon M, Sene D, Perard L, Karras A, Cacoub P: Rituximab combined with peg-interferon-ribavirin refractory hepatitis C virus-associated cryoglobulinemia vasculitis. Ann Rheum Dis 2008; 67: 1431-1436.
32. Ferri C, Cacoub P, Mazzaro C, Roccatello D, Scaini P, Sebastiani M, Tavoni A, Zignego AL, De Vita S: Treatment with rituximab in patients with mixed cryoglobulinemia syndrome: Results of multicenter cohort study and review of the literature. Autoimmun Rev 2011; 11: 48-55.
33. De Vita S, Quartuccio L, Isola M, Mazzaro C, Scaini P, Lenzi M, Campanini M, Naclerio C, Tavoni A, Pietrogrande M, Ferri C, Mascia M, Masolini P, Zabotti A, Maset M, Roccatello D, Zignego A, Pioltelli P, Gabrieli A, Filippini D, Perrella O, Migliaresi S, Galli M, Bombardieri S, Monti G: A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis. Arthritis Rheum 2012; 64: 843-853.
34. Ahmed M, Wong C: Should rituximab be the rescue therapy for refractory mixed cryoglobulinemia associated with hepatitis C? J Nephrol 2007; 20: 350-356.
35. Cacoub P, Delluc A, Saadoun D, Landau DA, Sene D: Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: Where do we stand? Ann Rheum Dis 2008; 67: 283-287.
36. El-Serag H, Hampel H, Yeh C, Rabaneck L: Extra-hepatic manifestations of hepatitis C among United States male veterans. Hepatology 2002; 36: 1439-1445.
37. Perico N, Cattaneo D, Bibkov B, Remuzzi G: Hepatitis C infection and chronic renal diseases. Clin J Am Soc Nephrol 2009; 4: 207-220.
38. Sneller M, Hu Z, Langford C: A randomized controlled trial of rituximab following failure of antiviral therapy for hepatitis C virusassociated cryoglobulinemic vasculitis. Arthritis Rheum 2012; 64: 835-842.
39. Basse G, Ribes D, Kamar N, Mehrenberger M, Sallusto F, Esposito L, Guitard J, Lavayssiere L, Oksman F, Durand D, Rostaing L: Rituximab therapy for mixed cryoglobulinemia in seven renal transplant patients. Transplant Proc 2006; 38: 2308-2310.
40. Fabrizi F, Martin P, Elli A, Montagnino G, Banfi G, Passerini P, Campise R, Tarantino A, Ponticelli C: Hepatitis C virus infection and rituximab therapy after renal transplantation. Int J Artif Organs 2007; 30: 445-449.
41. McHutchison JG, Everson GT, Gordon SC, Jacobson I, Sulkowski M, Kauffman R, Mc-Nair L, Alam J, Muir A, PROVE1 Study Team: Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009; 360: 1827-1838.
42. Hezode C, Forestier N, Dusheiko G, Ferenci P, Pol S, Goeser T, Browicki J, Bourliere M, Gharakhanian S, Bengtsson L, McNair L, George S, Kieffer T, Kwong A, Kauffman R, Alam J, Pawlotsky J, Zeuzem S, PROVE2 Study Team: Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009; 360: 1839-1850.
43. Ghany G, Nelson D, Strader D, Thomas D, Seeff L: An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases. Hepatology 2011; 54: 1433-1434.
44. Saadoun D, Rosenzwajg M, Joly F, Six A, Carrat F, Thibault V, Sene D, Cacoub P, Klatzmann D: Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N Engl J Med 2011; 365: 2067-2077.