Serum albumin acts as a shuttle to enhance cholesterol effl ux from cells

Journal of Lipid Research

Volumn 54, Issue 3, 2013, Pages 671-676

  Sankaranarayanan, Sandhya ^a   De La Llera Moya, Margarita ^a   Drazul Schrader, Denise ^a   Phillips, Michael C ^a   Kellner Weibel, Ginny ^a   Rothblat, George H ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Aqueous diffusion; Coronary artery disease; Low density lipoprotein

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; SERUM ALBUMIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN J774; CELL VACUOLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; CORONARY ARTERY DISEASE; HUMANS; LIPOPROTEINS; LIPOPROTEINS, LDL; SERUM ALBUMIN;

EID: 84874035043     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M031336     Document Type: Article

References (37)

1. Rothblat, G. H., and M. C. Phillips. 2010. High-density lipoprotein heterogeneity and function in reverse cholesterol transprot. Curr. Opin. Lipidol. 21 : 229-238.
2. Zhao, Y., T. J. C. Van Berkel, and M. Van Eck. 2010. Relative roles of various effl ux pathways in net cholesterol effl ux from macrophage foam cells in atherosclerotic lesions. Curr. Opin. Lipidol. 21 : 441-453.
3. Rosenson, R. S., H. B. Brewer, W. S. Davidson, Z. A. Fayad, V. Fuster, J. Goldstein, M. Hellerstein, X-C. Jiang, M. C. Phillips, D. J. Rader, et al. 2012. Cholesterol effl ux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation. 125 : 1905-1919.
4. Phillips, M. C., W. J. Johnson, and G. H. Rothblat. 1987. Mechanism and consequence of cellular cholesterol exchange and transfer. Biochim. Biophys. Acta. 906 : 223-276.
5. Kilsdonk, E. P. C., P. Yancey, G. Stoudt, F. W. Bangerter, W. J. Johnson, M. C. Phillips, and G. H. Rothblat. 1995. Cellular cholesterol effl ux mediated by cyclodextrins. J. Biol. Chem. 270 : 17250-17256.
6. Atger, V. M., M. de la Llera Moya, G. W. Stoudt, W. V. Rodrigueza, M. C. Phillips, and G. H. Rothblat. 1997. Cyclodextrins as catalysts for the removal of cholesterol from macrophage foam cells. J. Clin. Invest. 99 : 773-780.
7. Hoang, A., B. G. Drew, H. Low, A. T. Remaley, P. Nestel, B. A. Kingwell, and D. Sviridov. 2012. Mechanism of cholesterol effl ux in humans after infusion of reconstituted high-density lipoprotein. Eur. Heart J. 33 : 657-665.
8. Hatch, F. T., and R. S. Lees. 1968. Practical methods for plasma lipoprotein analysis. Adv. Lipid Res. 6 : 1-68.
9. McCloskey, H. M., G. H. Rothblat, and J. M. Glick. 1987. Incubation of acetylated low-density lipoprotein with cholesterol-rich dispersions enhances cholesterol uptake by macrophages. Biochim. Biophys. Acta. 921 : 320-332.
10. McLean, L. R., and M. C. Phillips. 1981. Mechanism of cholesterol and phosphatidylcholine exchange or transfer between unilamellar vesicles. Biochemistry. 20 : 2893-2900.
11. Klansek, J. J., P. G. Yancey, R. W. St.Clair, R. T. Fischer, W. J. Johnson, and J. M. Glick. 1995. Cholesterol quantitation by GLC: artifactual formation of short-chain esters. J. Lipid Res. 36 : 2261-2266.
12. Markwell, M. A. K., S. M. Haas, L. L. Bieber, and N. E. Tolbert. 1978. A modifi cation of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87 : 206-210.
13. Rothblat, G. H., and M. C. Phillips. 1982. Mechanism of cholesterol effl ux from cells. Effects of acceptor structure and concentration. J. Biol. Chem. 257 : 4775-4782.
14. Lund-Katz, S., B. Hammerschlag, and M. C. Phillips. 1982. Kinetics and mechanism of free cholesterol exchange between human serum high-and low-density lipoprotein. Biochemistry. 21 : 2964-2969.
15. Adorni, M. P., F. Zimetti, J. T. Billheimer, N. Wang, D. J. Rader, M. C. Phillips, and G. H. Rothblat. 2007. The role of different pathways in the release of cholesterol from macrophages. J. Lipid Res. 48 : 2453-2462.
16. Rodrigueza, W. V., K. J. Williams, G. H. Rothblat, and M. C. Phillips. 1997. Remodeling and shuttling: mechanisms for the synergistic effects between different acceptor particles in the mobilization of cellular cholesterol. Arterioscler. Thromb. Vasc. Biol. 17 : 383-393.
17. Zhao, Y., and Y. L. Marcel. 1996. Serum albumin is a signifi cant intermediate in cholesterol transport between cells and lipoproteins. Biochemistry. 35 : 7174-7180.
18. Ray, E., F. Bellini, G. Stoudt, S. Hemperly, and G. H. Rothblat. 1980. Infl uence of lecithin:cholesterol acyltransferase on cholesterol metabolism in hepatoma cells and hepatocytes. Biochim. Biophys. Acta. 617 : 318-334.
19. Fielding, C. J., J. Frohlich, K. Moser, and P. E. Fielding. 1982. Promotion of sterol effl ux and net transport by apolipoprotein E in lecithin: cholesterol acyltransferase defi ciency. Metabolism. 31 : 1023-1028.
20. Glomset, J. A., and J. L. Wright. 1964. Some properties of a cholesterol esterifying enzyme in human plasma. Biochim. Biophys. Acta. 89 : 266-276.
21. Fournier, N., V. Atger, J. L. Paul, M. de la Llera-Moya, G. H. Rothblat, and N. Moatti. 1999. Fractional effl ux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis. 147 : 227-235.
22. Czarnecka, H., and S. Yokoyama. 1995. Lecithin-cholesterol acyltransferase reaction on cellular lipid release by free apolipoprotein- mediated effl ux. Biochemistry. 34 : 4385-4392.
23. Fielding, C. J., and K. Moser. 1982. Evidence for the separation of albumin-and apo A-I-dependent mechanisms of cholesterol effl ux from cultured fi broblasts into human plasma. J. Biol. Chem. 257 : 10955-10960.
24. Burns, C. H., and G. H. Rothblat. 1969. Cholesterol excretion by tissue culture cells: effect of serum lipids. Biochim. Biophys. Acta. 176 : 616-625.
25. Chau, I. Y., and R. P. Geyer. 1978. The effects of serum albumin and phospholipid on sterol excretion in tissue culture cells. Biochim. Biophys. Acta. 542 : 214-221.
26. Haberland, M. E., and J. A. Reynolds. 1973. Self-association of cholesterol in aqueous solution. Proc. Natl. Acad. Sci. USA. 70 : 2313-2316.
27. Johnson, W. J., M. J. Bamberger, M. J. Latta, R. A. Rapp, M. C. Phillips, and G. H. Rothblat. 1986. The bidirectional fl ux of cholesterol between cells and lipoproteins. J. Biol. Chem. 261 : 5766-5776.
28. Kellner-Weibel, G., M. de la Llera-Moya, S. Sankaranarayanan, and G. H. Rothblat. 2010. In vitro studies and mass fl ux of cholesterol between serum and macrophages. In High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease. E. Schaefer, editor. Springer, New York. 83-88.
29. Zimetti, F., G. K. Weibel, M. N. Duong, and G. H. Rothblat. 2006. Measurement of cholesterol bidirectional fl ux between cells and lipoproteins. J. Lipid Res. 47 : 605-613.
30. Zidovetzki, R., and I. Levitan. 2007. Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim. Biophys. Acta. 1768 : 1311-1324.
31. Djoussé, L., K. J. Rothman, L. A. Cupples, D. Levy, and R. C. Ellison. 2002. Serum albumin and risk of myocardial infarction and all-cause mortality in the Framingham Offspring Study. Circulation. 106 : 2919-2924.
32. Nelson, J. J., D. Liao, A. R. Sharrett, A. R. Folsom, L. E. Chambless, E. Shahar, M. Szklo, J. Eckfeldt, and G. Heiss. 2000. Serum albumin level as a predictor of incident coronary heart disease. Am. J. Epidemiol. 151 : 468-477.
33. Gillum, R. F. 2000. Assessment of serum albumin concentration as a risk factor for stroke and coronary disease in African Americans and whites. J. Natl. Med. Assoc. 92 : 3-9.
34. Hung, K. T., S. Z. Berisha, B. M. Ritchey, J. Santore, and J. D. Smith. 2012. Red blood cells play a role in reverse cholesterol transport. Arterioscler. Thromb. Vasc. Biol. 32 : 1460-1465.
35. Giraud, F., and M. Claret. 1979. A study of cholesterol transfers between erythrocytes and lipid vesicles. FEBS Lett. 103 : 6-91.
36. Lange, Y., A. L. Molinaro, T. R. Chauncey, and T. L. Steck. 1983. On the mechanism of transfer of cholesterol between human erythrocytes and plasma. J. Biol. Chem. 258 : 6920-6926.
37. Gold, J. C., and M. C. Phillips. 1990. Effects of membrane lipid composition on the kinetics of cholesterol exchange between lipoproteins and different species of red blood cells. Biochim. Biophys. Acta. 1027 : 85-92.