메뉴 건너뛰기




Volumn , Issue , 2006, Pages 151-158

Pharmacological Activity of Saikosaponins

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84874034237     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (1)

References (34)
  • 1
    • 0018170669 scopus 로고
    • The effect of saikosaponins on biological membranes
    • Abe, H., Odashima, S., and Arichi, S. (1978) The effect of saikosaponins on biological membranes, Planta Med., 34, 287-290.
    • (1978) Planta Med , vol.34 , pp. 287-290
    • Abe, H.1    Odashima, S.2    Arichi, S.3
  • 3
    • 0031919320 scopus 로고    scopus 로고
    • Inhibitory effect of bupleuri radix saponins on adhesion of some solid tumor cells and relation to hemolytic action: Screening of 232 herbal drugs for anti-cell adhesion
    • Ahn, B-Z., Yoon, Y.-D., Lee, Y.H., Kim, B.-H., and Sok, D.-E. (1998) Inhibitory effect of Bupleuri radix saponins on adhesion of some solid tumor cells and relation to hemolytic action: screening of 232 herbal drugs for anti-cell adhesion, Planta Med., 64, 220-224.
    • (1998) Planta Med , vol.64 , pp. 220-224
    • Ahn, B.-Z.1    Yoon, Y.-D.2    Lee, Y.H.3    Kim, B.-H.4    Sok, D.-E.5
  • 5
    • 0036181495 scopus 로고    scopus 로고
    • Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from bupleurum rigidum and scrophularia scorodonia
    • Bermejo, P., Abad, M.J., Diaz, A.M., Fernandez, L., Santos, J.D., Sanchez, S., Villaescusa, L., Carrasco, L., and Irurzun, A. (2002) Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia, Planta Med., 68, 106-110.
    • (2002) Planta Med , vol.68 , pp. 106-110
    • Bermejo, P.1    Abad, M.J.2    Diaz, A.M.3    Fernandez, L.4    Santos, J.D.5    Sanchez, S.6    Villaescusa, L.7    Carrasco, L.8    Irurzun, A.9
  • 6
    • 0028788205 scopus 로고
    • Spontaneous and glucocorticoid-induced apoptosis in human mature t lymphocytes
    • Brunetti, M., Martelli, N., Colasante, A., Piantelli, M., Musiani, P., and Aiello, F.B. (1995) Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes, Blood, 86, 4199-4205.
    • (1995) Blood , vol.86 , pp. 4199-4205
    • Brunetti, M.1    Martelli, N.2    Colasante, A.3    Piantelli, M.4    Musiani, P.5    Aiello, F.B.6
  • 7
    • 0033157306 scopus 로고    scopus 로고
    • Saikosaponin-d up-regulates gr mrna expression and induces apoptosis in hl-60 cells
    • Bu, S., Xu, J., and Sun J. (1999) Saikosaponin-d up-regulates GR mRNA expression and induces apoptosis in HL-60 cells, Zhonghua Xue Ye Xue Za Zhi (abstract), 20, 354-356.
    • (1999) Zhonghua Xue Ye Xue Za Zhi (abstract) , vol.20 , pp. 354-356
    • Bu, S.1    Xu, J.2    Sun, J.3
  • 8
    • 0029081743 scopus 로고
    • Central administration of saikosaponin-d increases corticotropin-releasing factor mrna levels in the rat hypothalamus
    • Dobashi, I., Tozawa, F., Horiba, N., Sakai, Y., Sakai, K., and Suda, T. (1995) Central administration of saikosaponin-d increases corticotropin-releasing factor mRNA levels in the rat hypothalamus, Neurosci. Lett., 197, 235-238.
    • (1995) Neurosci. Lett , vol.197 , pp. 235-238
    • Dobashi, I.1    Tozawa, F.2    Horiba, N.3    Sakai, Y.4    Sakai, K.5    Suda, T.6
  • 9
    • 0028199779 scopus 로고
    • Biologically active triterpene saponins from bupleuri fruticosum
    • Guinea, M.C., Parellada, J., Lacaille-Dubois, M.A., and Wagner, H. (1994) Biologically active triterpene saponins from Bupleuri fruticosum, Planta Med., 60, 163-167.
    • (1994) Planta Med , vol.60 , pp. 163-167
    • Guinea, M.C.1    Parellada, J.2    Lacaille-Dubois, M.A.3    Wagner, H.4
  • 10
    • 0022244570 scopus 로고
    • Effects of saikosaponins on liver tyrosine aminotransferase activity induced by cortisone in adrenalectomized rats
    • Hashimoto, M., Inada, K., Ohminami, H., Kimura, Y., Ochuda, H., and Arichi, S. (1985) Effects of saikosaponins on liver tyrosine aminotransferase activity induced by cortisone in adrenalectomized rats, Planta Med., 41, 401-403.
    • (1985) Planta Med , vol.41 , pp. 401-403
    • Hashimoto, M.1    Inada, K.2    Ohminami, H.3    Kimura, Y.4    Ochuda, H.5    Arichi, S.6
  • 11
    • 0033638986 scopus 로고    scopus 로고
    • Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: Association with c-myc, p53, and bcl-2 mrna
    • Hsu, M.-J., Cheng, J.-S., and Huang, H.-C. (2000) Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA. Br. J. Pharmacol., 131, 1285-1293.
    • (2000) Br. J. Pharmacol , vol.131 , pp. 1285-1293
    • Hsu, M.-J.1    Cheng, J.-S.2    Huang, H.-C.3
  • 12
    • 0035902794 scopus 로고    scopus 로고
    • The chinese medicine bu-zhong-yi-qi-tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via g0/g1 arrest
    • Kao, S.-T., Yeh, C.-C., Hsieh, C.-C., Yang, M.-D., Lee, M.-R., Liu, H.-S., and Lin, J.-G. (2001) The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest, Life Sci., 69, 1485-1496.
    • (2001) Life Sci , vol.69 , pp. 1485-1496
    • Kao, S.-T.1    Yeh, C.-C.2    Hsieh, C.-C.3    Yang, M.-D.4    Lee, M.-R.5    Liu, H.-S.6    Lin, J.-G.7
  • 13
    • 0028903343 scopus 로고
    • Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and dna fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways
    • Kato, M., Pu, M., Isobe, K.-I., Hattori, T., Yanagita, N., and Nakashima, I. (1995) Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways, Immunopharmacology, 29, 207-213.
    • (1995) Immunopharmacology , vol.29 , pp. 207-213
    • Kato, M.1    Pu, M.2    Isobe, K.-I.3    Hattori, T.4    Yanagita, N.5    Nakashima, I.6
  • 14
    • 0031817156 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and eubacterium sp. A-44-infected gnotobiote rats
    • Kida, H., Akao, T., Meselhy, M.R., and Hattori, M. (1998) Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats, Biol. Pharm. Bull., 21, 588-593.
    • (1998) Biol. Pharm. Bull , vol.21 , pp. 588-593
    • Kida, H.1    Akao, T.2    Meselhy, M.R.3    Hattori, M.4
  • 15
    • 0024591935 scopus 로고
    • Activation of murine peritoneal macrophages by saikosaponin a, saikosaponin d and saikogenin d
    • Kumazawa, Y., Takimoto, H., Nishimura, C., Kawakita, T., and Nomoto, K. (1989) Activation of murine peritoneal macrophages by saikosaponin a, saikosaponin d and saikogenin d, Int. J. Immunopharmacol., 11, 21-28.
    • (1989) Int. J. Immunopharmacol , vol.11 , pp. 21-28
    • Kumazawa, Y.1    Takimoto, H.2    Nishimura, C.3    Kawakita, T.4    Nomoto, K.5
  • 16
    • 0024996606 scopus 로고
    • Protective effect of saikosaponin a, saikosaponin d and saikogenin d against pseudomonas aeruginosa infection in mice
    • Kumazawa, Y., Kawakita, T., Takimoto, H., and Nomoto, K. (1990) Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice, Int. J. Immu-nopharmacol., 12, 531-537.
    • (1990) Int. J. Immu-Nopharmacol , vol.12 , pp. 531-537
    • Kumazawa, Y.1    Kawakita, T.2    Takimoto, H.3    Nomoto, K.4
  • 18
    • 0028110031 scopus 로고
    • Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines
    • Motoo, Y. and Sawabu, N. (1949) Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines, Cancer Lett., 86, 91-95.
    • (1949) Cancer Lett , vol.86 , pp. 91-95
    • Motoo, Y.1    Sawabu, N.2
  • 19
    • 0024906443 scopus 로고
    • Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane
    • Nose, M., Amagaya, S., and Ogihara, Y. (1989) Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane, Chem. Pharm. Bull., 37, 3306-3310.
    • (1989) Chem. Pharm. Bull , vol.37 , pp. 3306-3310
    • Nose, M.1    Amagaya, S.2    Ogihara, Y.3
  • 20
    • 0036287107 scopus 로고    scopus 로고
    • Effect of saikosaponin-a, a triterpenoid glycoside, isolated from bupleurum falcatum on experimental allergic asthma
    • Park, K.H., Park, J., Koh, D., and Lim, Y. (2002) Effect of saikosaponin-A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma, Phytother. Res., 16, 359-363.
    • (2002) Phytother. Res , vol.16 , pp. 359-363
    • Park, K.H.1    Park, J.2    Koh, D.3    Lim, Y.4
  • 21
    • 0028969829 scopus 로고
    • Saikosaponin a-induced cell death of a human hepatoma cell line (Huh-7): The significance of the “sub-g1 peak” in a dna histogram
    • Qian, L., Murakami, T., Kimura, Y., Takahashi, M., and Okita, K. (1995) Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the “sub-G1 peak” in a DNA histogram, Pathol. Int., 45, 207-214.
    • (1995) Pathol. Int , vol.45 , pp. 207-214
    • Qian, L.1    Murakami, T.2    Kimura, Y.3    Takahashi, M.4    Okita, K.5
  • 22
    • 0034066205 scopus 로고    scopus 로고
    • Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma
    • Shimizu, I. (2000) Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma, J. Gastroenterol. Hepatol., 15(Suppl.), D84-90.
    • (2000) J. Gastroenterol. Hepatol , vol.15 , pp. D84-D90
    • Shimizu, I.1
  • 23
    • 0022406943 scopus 로고
    • Structural transformation of saikosaponins by gastric juice and intestinal flora
    • Shimizu, K., Amagaya, S., and Ogihara, Y. (1985) Structural transformation of saikosaponins by gastric juice and intestinal flora, J. Pharmacobiodyn., 8, 718-725.
    • (1985) J. Pharmacobiodyn , vol.8 , pp. 718-725
    • Shimizu, K.1    Amagaya, S.2    Ogihara, Y.3
  • 24
    • 0014517013 scopus 로고
    • Pharmacological studies on bupleurum falcatum. I. Acute toxicity and central depressant action of crude saikosides
    • Takagi, K. and Shibata, M. (1969a) Pharmacological studies on Bupleurum falcatum. I. Acute toxicity and central depressant action of crude saikosides, Yakugaku Zasshi, 89, 712-720.
    • (1969) Yakugaku Zasshi , vol.89 , pp. 712-720
    • Takagi, K.1    Shibata, M.2
  • 25
    • 0014581601 scopus 로고
    • Pharmacological studies on bupleurum falcatum. Ii. Antiinflammatory and other pharmacological actions of crude saikosides
    • Takagi, K. and Shibata, M. (1969b) Pharmacological studies on Bupleurum falcatum. II. Antiinflammatory and other pharmacological actions of crude saikosides, Yakugaku Zasshi, 89, 1367-1378.
    • (1969) Yakugaku Zasshi , vol.89 , pp. 1367-1378
    • Takagi, K.1    Shibata, M.2
  • 27
    • 0036222598 scopus 로고    scopus 로고
    • Induction of differentiation in rat c6 glioma cells with saikosaponins
    • Tsai, Y.J., Chen, I.L., Horng, L.Y., and Wu, R.T. (2002) Induction of differentiation in rat C6 glioma cells with saikosaponins, Phytother. Res., 16, 117-121.
    • (2002) Phytother. Res , vol.16 , pp. 117-121
    • Tsai, Y.J.1    Chen, I.L.2    Horng, L.Y.3    Wu, R.T.4
  • 28
    • 0025826683 scopus 로고
    • Effects of saikosaponin-d on the functions and morphology of macrophages
    • Ushio, Y. and Abe, H. (1991) Effects of saikosaponin-d on the functions and morphology of macrophages, Int. J. Immunopharmacol., 13, 493-499.
    • (1991) Int. J. Immunopharmacol , vol.13 , pp. 493-499
    • Ushio, Y.1    Abe, H.2
  • 29
    • 0034806214 scopus 로고    scopus 로고
    • Involvement of p-15ink4b and p-16ink4a gene expression in saikosaponin a and tpa-induced growth inhibition of hepg2 cells
    • INK4agene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells, Biochem. Biophys. Res. Commun., 285, 183-187.
    • (2001) Biochem. Biophys. Res. Commun , vol.285 , pp. 183-187
    • Wu, W.-S.1    Hsu, H.-Y.2
  • 30
    • 0016810474 scopus 로고
    • Structure and actions of saikosaponins isolated from bupleurum falcatum. I. Antiinflammatory action of saikosaponins
    • Yamamoto, M., Kumagai, A., and Yamamura, Y. (1975) Structure and actions of saikosaponins isolated from Bupleurum falcatum. I. Antiinflammatory action of saikosaponins, Arzneimittelforschung, 25, 1021-1023.
    • (1975) Arzneimittelforschung , vol.25 , pp. 1021-1023
    • Yamamoto, M.1    Kumagai, A.2    Yamamura, Y.3
  • 32
    • 0027948526 scopus 로고
    • Anti-inflammatory and hepatoprotective activity of saikosaponin-f and the root extract of
    • Yen, M.-H., Lin, C.-C., Chuang, C.-H., and Lin, S.-C. (1994) Anti-inflammatory and hepatoprotective activity of saikosaponin-f and the root extract of Bupleurum kaoi, Fitoterapia, 65, 409-417.
    • (1994) Bupleurum Kaoi, Fitoterapia , vol.65 , pp. 409-417
    • Yen, M.-H.1    Lin, C.-C.2    Chuang, C.-H.3    Lin, S.-C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.