Hydroxyethyl starch for intravenous volume replacement: More harm than benefit

JAMA

Volumn 309, Issue 7, 2013, Pages 723-724

  Antonelli, Massimo ^a   Sandroni, Claudio ^a  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; GELATIN; HETASTARCH; RINGER LACTATE SOLUTION;

CHEMICAL ANALYSIS; CLINICAL PRACTICE; COLLOID; CRYSTALLOID; EDITORIAL; EFFECT SIZE; FLUID THERAPY; HYDROXYETHYLATION; KIDNEY FAILURE; MISCONDUCT; MOLECULAR WEIGHT; MORBIDITY; MORTALITY; NEPHROTOXICITY; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; SAFETY; SEPSIS; SEPTIC SHOCK; TOXICITY TESTING;

EID: 84874008252     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2013.851     Document Type: Editorial

References (12)

1. Editors-in-Chief Statement Regarding Published Clinical Trials Conducted without IRB Approval by Joachim Boldt. 2011; http://www.aaeditor.org/EIC.Joint. Statement.on.Retractions.pdf. Accessed January 21, 2013.
2. Myburgh JA, Finfer S, Bellomo R, et al; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012;367(20):1901-1911.
3. Perner A, Haase N, Guttormsen AB, et al; 6S Trial Group; Scandinavian Critical Care Trials Group. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med. 2012;367(2):124-134.
4. Zarychanski R, Abou-Setta AM, Turgeon AF, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA. 2013;309(7):678-688.
5. Perel P, Roberts I. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2012;6:CD000567.
6. Guidet B, Martinet O, Boulain T, et al. Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs 0.9% NaCl fluid replacement in patients with severe sepsis: the CRYSTMAS study. Crit Care. 2012;16(3):R94.
7. Lukasewitz P, Kroh U, Lownstein O, Kreimer M, Lennartz H. Quantitatie measurement regarding the tissue storage of middle molecular hydroxyethyl startch 200/0,5 in patients with multiple organ failure [in German]. J Anästhesie Intensivbehandlung. 1998;3:42-46.
8. Jungheinrich C, Scharpf R, Wargenau M, Bepperling F, Baron JF. The pharmacokinetics and tolerability of an intravenous infusion of the new hydroxyethyl starch 130/0.4 (6%, 500 mL) in mild-to-severe renal impairment. Anesth Analg. 2002;95(3):544-551.
9. Hüter L, Simon TP, Weinmann L, et al. Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model. Crit Care. 2009;13(1):R23.
10. Shafer SL. Shadow of doubt. Anesth Analg. 2011;112(3):498-500.
11. Ludwigshafen Hospital presents results of final report: committee completes investigation in the case of Dr Boldt. Mainz, Germany: Klinikum Ludwigshafen; September 08, 2012. http://www.klilu.de/content/aktuelles-presse/ pressearchiv/2012/hospital-presents-results-of-final-report-committee-completes- investigation-in-the-case-of-dr-boldt/index-ger.html. Accessed January 21, 2013.
12. Blake H, Watt H, Winnett R. Millions of surgery patients at risk in drug research fraud scandal, The Telegraph. 2011; http://www.telegraph.co.uk/health/ 8360667/Millions-of-surgery-patients-at-risk-in-drug-research-fraud-scandal. html. Accessed January 21, 2013.