Urinary concentrations of human epidydimis secretory protein 4 (He4) in the diagnosis of ovarian cancer: A case-control study

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 9, 2012, Pages 4695-4698

  Macuks, Ronalds ^a,b   Baidekalna, Ieva ^a   Donina, Simona ^b,c  

^a RIGA STRADINS UNIVERSITY   (Latvia)

^b RIGA EAST UNIVERSITY HOSPITAL   (Latvia)

^c AKirhensteins institute of Microbiology and Virology   (Latvia)

Author keywords

Diagnostic marker; HE4; Ovarian cancer; Urine

Indexed keywords

EID: 84874004400     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.9.4695     Document Type: Article

References (17)

1. Boshell M, Lalani EN, Pemberton L, et al (1992). The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tail. Biochem Biophys Res Commun, 185, 1-8.
2. Davies DF, Shock NW (1950). Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest, 29, 496-507.
3. Drapkin R, von Horsten H, Lin Y, et al (2005). Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res, 65, 2162-9.
4. Guo L. Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cells proliferation and motility. 2nd World Congress on Biomarkers & Clinical Research, 12-14 September 2011, Baltimore Marriott Waterfront, USA.
5. Havrilesky LJ, Whitehead CM, Rubatt JM, et al (2008). Berchuck A. Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence. Gynecol Oncol, 110, 374-82.
6. Hellstrom I, Heagerty PJ, Swisher EM, et al (2010). Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms. Cancer Lett, 296, 43-8.
7. Hellstrom I, Raycraft J, Hayden-Ledbetter M, et al (2003). The HE4 (WFDC2) protein is a biomarker for ovarian cancer. Cancer Res, 63, 3695-3700.
8. Huhtinen K, Suvitie P, Hiissa J, (2009). Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. Br J Cancer, 100, 1315-9.
9. Kirchhoff C, Osterhoff C, Pera I, Schröter S (1998). Function of human epididymal proteins in sperm maturation. Andrologia, 30, 225-32.
10. Ligtenberg MJ, Kruijshaar L, Buijs F, et al (1992). Cell-associated episialin is a complex containing two proteins derived from a common precursor. J Biol Chem, 267, 6171-7.
11. Moore R, Brown A, Miller M, et al (2008). The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol, 108, 402-8.
12. Moore RG, Brown AK, Miller MC, et al (2008). The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol, 108, 402-8.
13. Partheen K, Kristjansdottir B, Sundfeldt K (2011). Evaluation of ovarian cancer biomarkers HE4 and CA-125 in women presenting with a suspicious cystic ovarian mass. J Gynecol Oncology, 22, 244-52.
14. Rosen DG, Wang L, Atkinson JN, et al (2005). Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol, 99, 267-77.
15. Schummer M, Ng WV, Bumgarner RE, et al (1999).Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene, 238, 375-85.
16. Van Gorp T, Cadron I, Despierre E, et al (2011). HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the risk of ovarian malignancy algorithm. Br J Cancer, 104, 863-70.
17. Yin BW, Lloyd KO (2001). Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J Biol Chem, 276, 27371-5