Cyclosporine-induced tubular vacuolization: The role of bip/Grp78

Nephron - Experimental Nephrology

Volumn 122, Issue 1-2, 2013, Pages 1-12

  Cheng, Chi Hung ^a,b,c   Shu, Kuo Hsiung ^b   Chang, Horng Rong ^a   Chou, Ming Chih ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Bip Grp78; Cyclosporine; ER stress

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CHAPERONIN 60; CYCLOSPORIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PROTEIN IRE1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM STRESS; KIDNEY PROXIMAL TUBULE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL LINE; CYCLOSPORINE; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TUBULES, PROXIMAL; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL; VACUOLES;

EID: 84874003290     PISSN: None     EISSN: 16602129     Source Type: Journal    
DOI: 10.1159/000346956     Document Type: Article

References (17)

1. Sis B, Einecke G, Chang J, et al: Cluster analysis of lesions in nonselected kidney transplant biopsies: microcirculation changes, tubulointerstitial inflammation and scarring. Am J Transplant 2010; 10: 421.
2. Liptak P, Ivanyi B: Primer: Histopathology of calcineurin-inhibitor toxicity in renal allografts. Nat Clin Pract Nephrol 2006; 2: 398-404.
3. Mihatsch MJ, Ryffel B, Hermle M, Brunner FP, Thiel G: Morphology of cyclosporine nephrotoxicity in the rat. Clin Nephrol 1986; 25(suppl 1):S2-S8.
4. Prevot A, Semama DS, Justrabo E, Guignard JP, Escousse A, Gouyon JB: Acute cyclosporine A-induced nephrotoxicity: a rabbit model. Pediatr Nephrol 2000; 14: 370-375.
5. Bredesen DE, Rao RV, Mechlen P: Cell death in the nervous system. Nature 2006; 443: 796-802.
6. Young J, Agashe V, Siegers K, Hartl U: Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol 2004; 5: 5781-5791.
7. Sitia R, Braakman R: Quality control in the endoplasmic reticulum protein factory. Nature 2003; 426: 891-894.
8. Pallet N, Bouver N, Bendjallabah A, et al: Cyclosporine-induced endoplasmic reticulum stress trigger tubular phenotypic changes and death. Am J Transplant 2008; 8: 2283-2296.
9. Sitia R, Braakman R: Quality control in the endoplasmic reticulum protein factory. Nature 2003; 426: 891-894.
10. Scheuner D, Song B, McEwen E, et al: Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001; 7: 1165-1176.
11. Bertolotti A, Zhang Y, Hendershot LM, Harding H, Ron D: Dynamic interaction of Bip and ER stress transducers in the unfolded protein response. Nat Cell Biol 2000; 2: 328-332.
12. Bradshaw R, Dennis E (eds): Handbook of Cell Signaling. New York, Academic Press Elsevier Science, 2003, vol 3, pp 269-275.
13. Vemba ST, Brodsy JL, Shruthi SV: One step a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol 2008; 9: 944-956.
14. Morris JA, Dorner AJ, Edward CA, Hendershot LM, Kaufman J: Immunoglobulin binding protein function is required to protect cell from endoplasmic reticulum stress but is not required for the secretion of selective protein. J Biol Chem 1997; 272: 4327-4334.
15. Bertocchio JP, van Huyen JP, Moghrabi SE, Rieu P, Jaisser F: Beneficial effect of mineralcorticoid receptor antagonism in acute cyclosporine A nephrotoxicity. ASN 2010.
16. Bobadilla NA, Gamba G: New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone. Am J Physiol Renal Physiol 2007; 290:F2-F9.
17. Naeans M, Kuyper DRJ, Sarwal M: Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 2009; 4: 481-508.